Preclinical and clinical evaluation of the liver tumor irreversible electroporation by magnetic resonance imaging

Matteo Figini, Xifu Wang, Tianchu Lyu, Zhanliang Su, Daniele Procissi, Vahid Yaghmai, Andrew C. Larson, Zhuoli Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Irreversible electroporation (IRE) is a relatively new technique for tumor ablation. It has shown promising results in difficult cases where surgery is not recommended and delicate anatomic structures are present near or within the tumor. Currently, liver cancer is one of the most common targets for IRE treatment. Pre-operative and post-operative imaging has a key role in IRE procedures and research studies. Although ultrasound is usually the first choice, especially for intra-operative guidance, magnetic resonance imaging (MRI) plays an important role in the visualization and characterization of tumor before and after IRE in clinical and preclinical studies. However, the appearance of liver lesions after IRE with different MRI sequences has never been systematically investigated, and the most common practice is to limit the acquisition protocol to only contrast-enhanced T1-weighted images. In this work, the role of MRI in clinical and preclinical assessment of hepatic tumors treated with IRE is reviewed and discussed.

Original languageEnglish (US)
Article numberAJTR0037958
Pages (from-to)580-590
Number of pages11
JournalAmerican Journal of Translational Research
Issue number2
StatePublished - 2017


  • Irreversible electroporation
  • Liver
  • Magnetic resonance imaging
  • Therapy response

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research


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