Preclinical contraceptive development for men and women

Daniel S. Johnston*, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


This manuscript endeavors to present research considerations for the preclinical development of non-hormonal contraceptives. Topics include (1) how advances in genomics and bioinformatics impact the identification of novel targets for non-hormonal contraception, (2) the importance of target validation prior to investment in a contraceptive development campaign, (3) considerations on targeting gametogenesis vs gamete maturation/function, (4) how targets from the male reproductive system are expanding women's options for 'on demand' contraception, and (5) some emerging non-hormonal methods that are not based on a specific molecular target. Also presented are ideas for developing a pipeline of non-hypothalamic-pituitary-gonadal-acting contraceptives for men and women while balancing risk and innovation, and our perspective on the pros and cons of industry and academic environments on contraceptive development. Three product development programs are highlighted that are biologically interesting, innovative, and likely to influence the field of contraceptive development in years to come.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalBiology of reproduction
Issue number2
StatePublished - Aug 1 2020


  • Contraception

ASJC Scopus subject areas

  • Cell Biology
  • Reproductive Medicine


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