Abstract
This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.
| Original language | English (US) |
|---|---|
| Article number | 114440 |
| Journal | journal of pediatrics |
| Volume | 278 |
| DOIs | |
| State | Published - Mar 2025 |
Funding
Data Availability: The EHR dataset used in this study cannot be shared publicly due to privacy regulations imposed by HIPAA. However, researchers interested in gaining access to the deidentified and aggregate versions of this data are encouraged to contact the authors for data availability. Access to the data will be granted upon request, subject to the necessary approval from their respective Institutional Review Boards (IRBs) or Ethics Review Committees (ERCs).
Keywords
- NF1
- neurofibromatosis
- optic pathway glioma
- precocious puberty
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health