Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance)

M. A. Fuchs, C. Yuan, K. Sato, D. Niedzwiecki, X. Ye, L. B. Saltz, R. J. Mayer, R. B. Mowat, R. Whittom, A. Hantel, Al B Benson III, D. Atienza, M. Messino, H. Kindler, A. Venook, F. Innocenti, R. S. Warren, M. M. Bertagnolli, S. Ogino, E. L. Giovannucci & 3 others E. Horvath, J. A. Meyerhardt, K. Ng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Observational studies suggest that higher levels of 25-hydroxyvitamin D3 (25(OH)D) are associated with areduced risk of colorectal cancer and improved survival of colorectal cancer patients. However, the influence of vitamin D statuson cancer recurrence and survival of patients with stage III colon cancer is unknown. Patients and methods: We prospectively examined the influence of post-diagnosis predicted plasma 25(OH)D on outcomeamong 1016 patients with stage III colon cancer who were enrolled in a National Cancer Institute-sponsored adjuvant therapytrial (CALGB 89803). Predicted 25(OH)D scores were computed using validated regression models. We examined the influenceof predicted 25(OH)D scores on cancer recurrence and mortality (disease-free survival; DFS) using Cox proportional hazards. Results: Patients in the highest quintile of predicted 25(OH)D score had an adjusted hazard ratio (HR) for colon cancerrecurrence or mortality (DFS) of 0.62 (95% confidence interval [CI], 0.44-0.86), compared with those in the lowest quintile(Ptrend=0.005). Higher predicted 25(OH)D score was also associated with a significant improvement in recurrence-free survivaland overall survival (Ptrend=0.01 and 0.0004, respectively). The benefit associated with higher predicted 25(OH)D score appearedconsistent across predictors of cancer outcome and strata of molecular tumor characteristics, including microsatellite instabilityand KRAS, BRAF, PIK3CA, and TP53 mutation status. Conclusion: Higher predicted 25(OH)D levels after a diagnosis of stage III colon cancer may be associated with decreased recurrenceand improved survival. Clinical trials assessing the benefit of vitamin D supplementation in the adjuvant setting are warranted.

Original languageEnglish (US)
Article numbermdx109
Pages (from-to)1359-1367
Number of pages9
JournalAnnals of Oncology
Volume28
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Vitamin D
Colonic Neoplasms
Recurrence
Mortality
Survival
Colorectal Neoplasms
Neoplasms
Calcifediol
National Cancer Institute (U.S.)
Microsatellite Repeats
Disease-Free Survival
Observational Studies
Colon
Clinical Trials
Confidence Intervals
Mutation

Keywords

  • Colorectal neoplasm
  • Prospective studies
  • Survival analysis
  • Vitamin D

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Fuchs, M. A., Yuan, C., Sato, K., Niedzwiecki, D., Ye, X., Saltz, L. B., ... Ng, K. (2017). Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). Annals of Oncology, 28(6), 1359-1367. [mdx109]. https://doi.org/10.1093/annonc/mdx109
Fuchs, M. A. ; Yuan, C. ; Sato, K. ; Niedzwiecki, D. ; Ye, X. ; Saltz, L. B. ; Mayer, R. J. ; Mowat, R. B. ; Whittom, R. ; Hantel, A. ; Benson III, Al B ; Atienza, D. ; Messino, M. ; Kindler, H. ; Venook, A. ; Innocenti, F. ; Warren, R. S. ; Bertagnolli, M. M. ; Ogino, S. ; Giovannucci, E. L. ; Horvath, E. ; Meyerhardt, J. A. ; Ng, K. / Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). In: Annals of Oncology. 2017 ; Vol. 28, No. 6. pp. 1359-1367.
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abstract = "Background: Observational studies suggest that higher levels of 25-hydroxyvitamin D3 (25(OH)D) are associated with areduced risk of colorectal cancer and improved survival of colorectal cancer patients. However, the influence of vitamin D statuson cancer recurrence and survival of patients with stage III colon cancer is unknown. Patients and methods: We prospectively examined the influence of post-diagnosis predicted plasma 25(OH)D on outcomeamong 1016 patients with stage III colon cancer who were enrolled in a National Cancer Institute-sponsored adjuvant therapytrial (CALGB 89803). Predicted 25(OH)D scores were computed using validated regression models. We examined the influenceof predicted 25(OH)D scores on cancer recurrence and mortality (disease-free survival; DFS) using Cox proportional hazards. Results: Patients in the highest quintile of predicted 25(OH)D score had an adjusted hazard ratio (HR) for colon cancerrecurrence or mortality (DFS) of 0.62 (95{\%} confidence interval [CI], 0.44-0.86), compared with those in the lowest quintile(Ptrend=0.005). Higher predicted 25(OH)D score was also associated with a significant improvement in recurrence-free survivaland overall survival (Ptrend=0.01 and 0.0004, respectively). The benefit associated with higher predicted 25(OH)D score appearedconsistent across predictors of cancer outcome and strata of molecular tumor characteristics, including microsatellite instabilityand KRAS, BRAF, PIK3CA, and TP53 mutation status. Conclusion: Higher predicted 25(OH)D levels after a diagnosis of stage III colon cancer may be associated with decreased recurrenceand improved survival. Clinical trials assessing the benefit of vitamin D supplementation in the adjuvant setting are warranted.",
keywords = "Colorectal neoplasm, Prospective studies, Survival analysis, Vitamin D",
author = "Fuchs, {M. A.} and C. Yuan and K. Sato and D. Niedzwiecki and X. Ye and Saltz, {L. B.} and Mayer, {R. J.} and Mowat, {R. B.} and R. Whittom and A. Hantel and {Benson III}, {Al B} and D. Atienza and M. Messino and H. Kindler and A. Venook and F. Innocenti and Warren, {R. S.} and Bertagnolli, {M. M.} and S. Ogino and Giovannucci, {E. L.} and E. Horvath and Meyerhardt, {J. A.} and K. Ng",
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Fuchs, MA, Yuan, C, Sato, K, Niedzwiecki, D, Ye, X, Saltz, LB, Mayer, RJ, Mowat, RB, Whittom, R, Hantel, A, Benson III, AB, Atienza, D, Messino, M, Kindler, H, Venook, A, Innocenti, F, Warren, RS, Bertagnolli, MM, Ogino, S, Giovannucci, EL, Horvath, E, Meyerhardt, JA & Ng, K 2017, 'Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance)' Annals of Oncology, vol. 28, no. 6, mdx109, pp. 1359-1367. https://doi.org/10.1093/annonc/mdx109

Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). / Fuchs, M. A.; Yuan, C.; Sato, K.; Niedzwiecki, D.; Ye, X.; Saltz, L. B.; Mayer, R. J.; Mowat, R. B.; Whittom, R.; Hantel, A.; Benson III, Al B; Atienza, D.; Messino, M.; Kindler, H.; Venook, A.; Innocenti, F.; Warren, R. S.; Bertagnolli, M. M.; Ogino, S.; Giovannucci, E. L.; Horvath, E.; Meyerhardt, J. A.; Ng, K.

In: Annals of Oncology, Vol. 28, No. 6, mdx109, 01.06.2017, p. 1359-1367.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance)

AU - Fuchs, M. A.

AU - Yuan, C.

AU - Sato, K.

AU - Niedzwiecki, D.

AU - Ye, X.

AU - Saltz, L. B.

AU - Mayer, R. J.

AU - Mowat, R. B.

AU - Whittom, R.

AU - Hantel, A.

AU - Benson III, Al B

AU - Atienza, D.

AU - Messino, M.

AU - Kindler, H.

AU - Venook, A.

AU - Innocenti, F.

AU - Warren, R. S.

AU - Bertagnolli, M. M.

AU - Ogino, S.

AU - Giovannucci, E. L.

AU - Horvath, E.

AU - Meyerhardt, J. A.

AU - Ng, K.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Observational studies suggest that higher levels of 25-hydroxyvitamin D3 (25(OH)D) are associated with areduced risk of colorectal cancer and improved survival of colorectal cancer patients. However, the influence of vitamin D statuson cancer recurrence and survival of patients with stage III colon cancer is unknown. Patients and methods: We prospectively examined the influence of post-diagnosis predicted plasma 25(OH)D on outcomeamong 1016 patients with stage III colon cancer who were enrolled in a National Cancer Institute-sponsored adjuvant therapytrial (CALGB 89803). Predicted 25(OH)D scores were computed using validated regression models. We examined the influenceof predicted 25(OH)D scores on cancer recurrence and mortality (disease-free survival; DFS) using Cox proportional hazards. Results: Patients in the highest quintile of predicted 25(OH)D score had an adjusted hazard ratio (HR) for colon cancerrecurrence or mortality (DFS) of 0.62 (95% confidence interval [CI], 0.44-0.86), compared with those in the lowest quintile(Ptrend=0.005). Higher predicted 25(OH)D score was also associated with a significant improvement in recurrence-free survivaland overall survival (Ptrend=0.01 and 0.0004, respectively). The benefit associated with higher predicted 25(OH)D score appearedconsistent across predictors of cancer outcome and strata of molecular tumor characteristics, including microsatellite instabilityand KRAS, BRAF, PIK3CA, and TP53 mutation status. Conclusion: Higher predicted 25(OH)D levels after a diagnosis of stage III colon cancer may be associated with decreased recurrenceand improved survival. Clinical trials assessing the benefit of vitamin D supplementation in the adjuvant setting are warranted.

AB - Background: Observational studies suggest that higher levels of 25-hydroxyvitamin D3 (25(OH)D) are associated with areduced risk of colorectal cancer and improved survival of colorectal cancer patients. However, the influence of vitamin D statuson cancer recurrence and survival of patients with stage III colon cancer is unknown. Patients and methods: We prospectively examined the influence of post-diagnosis predicted plasma 25(OH)D on outcomeamong 1016 patients with stage III colon cancer who were enrolled in a National Cancer Institute-sponsored adjuvant therapytrial (CALGB 89803). Predicted 25(OH)D scores were computed using validated regression models. We examined the influenceof predicted 25(OH)D scores on cancer recurrence and mortality (disease-free survival; DFS) using Cox proportional hazards. Results: Patients in the highest quintile of predicted 25(OH)D score had an adjusted hazard ratio (HR) for colon cancerrecurrence or mortality (DFS) of 0.62 (95% confidence interval [CI], 0.44-0.86), compared with those in the lowest quintile(Ptrend=0.005). Higher predicted 25(OH)D score was also associated with a significant improvement in recurrence-free survivaland overall survival (Ptrend=0.01 and 0.0004, respectively). The benefit associated with higher predicted 25(OH)D score appearedconsistent across predictors of cancer outcome and strata of molecular tumor characteristics, including microsatellite instabilityand KRAS, BRAF, PIK3CA, and TP53 mutation status. Conclusion: Higher predicted 25(OH)D levels after a diagnosis of stage III colon cancer may be associated with decreased recurrenceand improved survival. Clinical trials assessing the benefit of vitamin D supplementation in the adjuvant setting are warranted.

KW - Colorectal neoplasm

KW - Prospective studies

KW - Survival analysis

KW - Vitamin D

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DO - 10.1093/annonc/mdx109

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Fuchs MA, Yuan C, Sato K, Niedzwiecki D, Ye X, Saltz LB et al. Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). Annals of Oncology. 2017 Jun 1;28(6):1359-1367. mdx109. https://doi.org/10.1093/annonc/mdx109