Predicting and Manipulating Cone Responses to Naturalistic Inputs

Juan M. Angueyra, Jacob Baudin, Gregory W. Schwartz, Fred Rieke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Primates explore their visual environment by making frequent saccades, discrete and ballistic eye movements that direct the fovea to specific regions of interest. Saccades produce large and rapid changes in input. The magnitude of these changes and the limited signaling range of visual neurons mean that effective encoding requires rapid adaptation. Here, we explore how macaque cone photoreceptors maintain sensitivity under these conditions. Adaptation makes cone responses to naturalistic stimuli highly nonlinear and dependent on stimulus history. Such responses cannot be explained by linear or linear-nonlinear models but are well explained by a biophysical model of phototransduction based on well-established biochemical interactions. The resulting model can predict cone responses to a broad range of stimuli and enables the design of stimuli that elicit specific (e.g., linear) cone photocurrents. These advances will provide a foundation for investigating the contributions of cone phototransduction and post-transduction processing to visual function.

Original languageEnglish (US)
Pages (from-to)1254-1274
Number of pages21
JournalJournal of Neuroscience
Issue number7
StatePublished - Feb 16 2022


  • neural coding
  • photoreceptors
  • phototransduction
  • retina
  • sensory processing

ASJC Scopus subject areas

  • Medicine(all)


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