Predicting and Modifying Risk for Development of Renal Failure in Boys with Posterior Urethral Valves

Christopher J. Long*, Diana Katherine Bowen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Purpose of Review: The purpose of this review is to bring the reader up to date on the current risk factors for the development of renal deterioration in the boys with posterior urethral valves (PUV) and approaches to modify this risk. Recent Findings: Renal bladder ultrasound (RBUS) is routinely performed in boys with PUV and recent advancements allow imaging processing that can more accurately quantify renal parenchyma and correlate this with risk for renal loss. Refinement of urine studies may improve our ability to stratify patients into renal loss categories. Use of videourodynamics (VUDS) allows refined assessment of the valve bladder to identify those who might benefit from secondary procedures and/or the addition of targeted pharmacotherapy to improve bladder emptying or dangerous storage pressures. Summary: All boys with a history of PUV are at a significant long-term risk of renal deterioration. The literature suggests that several technical advances have improved our ability to predict this risk, although there needs to be further refinement and validation before widespread use. Utilization of close follow-up, VUDS, pharmacotherapy, and bladder drainage provide the best methods to improve care to this group of patients and if more studies confirm their utility, adoption of these as part of standard of care protocols may be warranted.

Original languageEnglish (US)
Article number55
JournalCurrent urology reports
Issue number7
StatePublished - Jul 1 2018


  • Anticholinergic
  • Posterior urethral valves
  • Renal insufficiency
  • Ultrasound

ASJC Scopus subject areas

  • Urology


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