Predicting backscatter characteristics from micron- And submicron- Scale ultrasound contrast agents using a size-integration technique

Hairong Zheng; Alexander Barker; Robin Shandas

doi:10.1109/TUFFC.2006.1610573

Predicting backscatter characteristics from micron- And submicron- Scale ultrasound contrast agents using a size-integration technique

Hairong Zheng^*, Alexander Barker, Robin Shandas

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

In this paper, a computationally, inexpensive, size-integration method based on a modified Rayleigh-Plesset model is developed to predict backscatter spectra from groups of bubbles with various size distributions, incident acoustic amplitudes, and driving frequencies. The method was validated using experimentally measured spectra from contrast bubbles of various sizes: Optison®, Levovist®, ST68® microbubbles, and submicron bubbles. This method provides a computationally inexpensive means of examining backscatter spectrum from multiple bubbles, especially in predicting occurrence and relative amplitude of subharmonics and second harmonics.

Original language	English (US)
Pages (from-to)	639-644
Number of pages	6
Journal	IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume	53
Issue number	3
DOIs	https://doi.org/10.1109/TUFFC.2006.1610573
State	Published - Mar 1 2006

Funding

The authors would like to thank Prof. M. A. Wheatley and Dr. W. T. Shi for their valuable discussion. Additionally, H. R. Zheng acknowledges the support of CU Boulder Engineering Excellence Fund (EEF), GEERS fellowship on acoustics, and predoctoral fellowship grant (0515182Z) from the American Heart Association Pacific Mountain Affiliate. Manuscript received September 25, 2005; accepted October 10, 2005. This work was made possible in part by grants from NSF (EECS-0225405 and CTS-0421461) and NIH (HL72738 and 67393).

ASJC Scopus subject areas

Instrumentation
Electrical and Electronic Engineering
Acoustics and Ultrasonics

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10.1109/TUFFC.2006.1610573

Cite this

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abstract = "In this paper, a computationally, inexpensive, size-integration method based on a modified Rayleigh-Plesset model is developed to predict backscatter spectra from groups of bubbles with various size distributions, incident acoustic amplitudes, and driving frequencies. The method was validated using experimentally measured spectra from contrast bubbles of various sizes: Optison{\textregistered}, Levovist{\textregistered}, ST68{\textregistered} microbubbles, and submicron bubbles. This method provides a computationally inexpensive means of examining backscatter spectrum from multiple bubbles, especially in predicting occurrence and relative amplitude of subharmonics and second harmonics.",

author = "Hairong Zheng and Alexander Barker and Robin Shandas",

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doi = "10.1109/TUFFC.2006.1610573",

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Predicting backscatter characteristics from micron- And submicron- Scale ultrasound contrast agents using a size-integration technique. / Zheng, Hairong; Barker, Alexander; Shandas, Robin.
In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 53, No. 3, 01.03.2006, p. 639-644.

Research output: Contribution to journal › Article › peer-review

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Predicting backscatter characteristics from micron- And submicron- Scale ultrasound contrast agents using a size-integration technique

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