TY - JOUR
T1 - Predicting backscatter characteristics from micron- And submicron- Scale ultrasound contrast agents using a size-integration technique
AU - Zheng, Hairong
AU - Barker, Alexander
AU - Shandas, Robin
N1 - Funding Information:
The authors would like to thank Prof. M. A. Wheatley and Dr. W. T. Shi for their valuable discussion. Additionally, H. R. Zheng acknowledges the support of CU Boulder Engineering Excellence Fund (EEF), GEERS fellowship on acoustics, and predoctoral fellowship grant (0515182Z) from the American Heart Association Pacific Mountain Affiliate.
Funding Information:
Manuscript received September 25, 2005; accepted October 10, 2005. This work was made possible in part by grants from NSF (EECS-0225405 and CTS-0421461) and NIH (HL72738 and 67393).
PY - 2006/3/1
Y1 - 2006/3/1
N2 - In this paper, a computationally, inexpensive, size-integration method based on a modified Rayleigh-Plesset model is developed to predict backscatter spectra from groups of bubbles with various size distributions, incident acoustic amplitudes, and driving frequencies. The method was validated using experimentally measured spectra from contrast bubbles of various sizes: Optison®, Levovist®, ST68® microbubbles, and submicron bubbles. This method provides a computationally inexpensive means of examining backscatter spectrum from multiple bubbles, especially in predicting occurrence and relative amplitude of subharmonics and second harmonics.
AB - In this paper, a computationally, inexpensive, size-integration method based on a modified Rayleigh-Plesset model is developed to predict backscatter spectra from groups of bubbles with various size distributions, incident acoustic amplitudes, and driving frequencies. The method was validated using experimentally measured spectra from contrast bubbles of various sizes: Optison®, Levovist®, ST68® microbubbles, and submicron bubbles. This method provides a computationally inexpensive means of examining backscatter spectrum from multiple bubbles, especially in predicting occurrence and relative amplitude of subharmonics and second harmonics.
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U2 - 10.1109/TUFFC.2006.1610573
DO - 10.1109/TUFFC.2006.1610573
M3 - Article
C2 - 16555773
AN - SCOPUS:31344433755
VL - 53
SP - 639
EP - 644
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
SN - 0885-3010
IS - 3
ER -