Predicting invasive breast cancer versus DCIS in different age groups

Mehmet U.S. Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A. Sickles, Houssam Nassif, Karla Kerlikowske, Elizabeth S. Burnside*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: Increasing focus on potentially unnecessary diagnosis and treatment of certain breast cancers prompted our investigation of whether clinical and mammographic features predictive of invasive breast cancer versus ductal carcinoma in situ (DCIS) differ by age.Methods: We analyzed 1,475 malignant breast biopsies, 1,063 invasive and 412 DCIS, from 35,871 prospectively collected consecutive diagnostic mammograms interpreted at University of California, San Francisco between 1/6/1997 and 6/29/2007. We constructed three logistic regression models to predict the probability of invasive cancer versus DCIS for the following groups: women ≥ 65 (older group), women 50-64 (middle age group), and women < 50 (younger group). We identified significant predictors and measured the performance in all models using area under the receiver operating characteristic curve (AUC).Results: The models for older and the middle age groups performed significantly better than the model for younger group (AUC = 0.848 vs, 0.778; p = 0.049 and AUC = 0.851 vs, 0.778; p = 0.022, respectively). Palpability and principal mammographic finding were significant predictors in distinguishing invasive from DCIS in all age groups. Family history of breast cancer, mass shape and mass margins were significant positive predictors of invasive cancer in the older group whereas calcification distribution was a negative predictor of invasive cancer (i.e. predicted DCIS). In the middle age group-mass margins, and in the younger group-mass size were positive predictors of invasive cancer.Conclusions: Clinical and mammographic finding features predict invasive breast cancer versus DCIS better in older women than younger women. Specific predictive variables differ based on age.

Original languageEnglish (US)
Article number584
JournalBMC cancer
Volume14
Issue number1
DOIs
StatePublished - Aug 11 2014
Externally publishedYes

Keywords

  • Aging
  • Biopsy
  • Breast neoplasms
  • Logistic models
  • Mammography
  • Overdiagnosis

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

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