Prediction of hematocrit decline after intravascuiar fetal transfusion

Scott N. MacGregor*, Michael L. Socol, Bruce W. Pielet, John S. Sholl, Richard K. Silver

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Fetal blood sampling and intravascular transfusion via cordocentesis allow more precise fetal evaluation and treatment in isoimmunized pregnancies. However, the timing of repeat transfusion has retrained empiric. In this report we review our experience with fetal transfusions in isoimmunized pregnancies to evaluate the ability to predict fetal hematocrit decline and thereby determine the optimum timing for repeat transfusions. Between March 1986 and March 1988, 60 intravascular fetal transfusions were performed in 20 patients. Fetal transfusions were excluded from analysis if blood samples were unable to be obtained before and after transfusion, as well as at the beginning of the next transfusion or birth. Fifty-three procedures were analyzed. Two equations were used to predict the fetal hernatocrit at the subsequent transfusion. The difference between observed and predicted hematocrits at the beginning of a subsequent transfusion or birth was -0.9% ± 5.8% with equation 2, which was the more accurate formula in the majority of fetuses. Prediction of fetal hematocrit decline may be used to determine the optimum timing of repeat transfusion.

Original languageEnglish (US)
Pages (from-to)1491-1493
Number of pages3
JournalAmerican journal of obstetrics and gynecology
Volume161
Issue number6 PART 1
DOIs
StatePublished - Dec 1989

Keywords

  • Fetal transfusion
  • cordocentesis
  • fetal therapy
  • isoimmunization

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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