Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana

Amelia E. Van Pelt; Tyler M. Moore; J. Cobb Scott; Onkemetse Phoi; Lingani Mbakile-Mahlanza; Knashawn H. Morales; Ruben C. Gur; Shathani Rampa; Mogomotsi Matshaba; Elizabeth D. Lowenthal

doi:10.1007/s10461-022-03620-w

Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana

Amelia E. Van Pelt^*, Tyler M. Moore, J. Cobb Scott, Onkemetse Phoi, Lingani Mbakile-Mahlanza, Knashawn H. Morales, Ruben C. Gur, Shathani Rampa, Mogomotsi Matshaba, Elizabeth D. Lowenthal

^*Corresponding author for this work

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Children living with HIV (HIV+) experience increased risk of neurocognitive deficits, but standardized cognitive testing is limited in low-resource, high-prevalence settings. The Penn Computerized Neurocognitive Battery (PennCNB) was adapted for use in Botswana. This study evaluated the criterion validity of a locally adapted version of the PennCNB among a cohort of HIV+ individuals aged 10–17 years in Botswana. Participants completed the PennCNB and a comprehensive professional consensus assessment consisting of pencil-and-paper psychological assessments, clinical interview, and review of academic performance. Seventy-two participants were classified as cases (i.e., with cognitive impairment; N = 48) or controls (i.e., without cognitive impairment; N = 24). Sensitivity, specificity, positive predictive value, negative predictive value, and the area under receiver operating characteristic curves were calculated. Discrimination was acceptable, and prediction improved as the threshold for PennCNB impairment was less conservative. This research contributes to the validation of the PennCNB for use among children affected by HIV in Botswana.

Original language	English (US)
Pages (from-to)	2758-2767
Number of pages	10
Journal	AIDS and behavior
Volume	26
Issue number	8
DOIs	https://doi.org/10.1007/s10461-022-03620-w
State	Published - Aug 2022

Funding

This research was supported by the National Institute of Child Health and Human Development (F31 HD101346 and R01 HD095278). This publication was made possible in part through core services and support from the Penn Center for AIDS Research (CFAR), an NIH-funded (P30 045088) program and the Penn Mental Health AIDS Research Center (PMHARC; P30 MH097488). TMM is supported by NIMH R01 MH117014 and by the Lifespan Brain Institute (LiBI) of Penn Medicine and CHOP.

Keywords

Botswana
Criterion validity
Neurocognitive assessment
Setswana translation
Youth

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Infectious Diseases
Social Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10461-022-03620-w

Cite this

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title = "Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana",

abstract = "Children living with HIV (HIV+) experience increased risk of neurocognitive deficits, but standardized cognitive testing is limited in low-resource, high-prevalence settings. The Penn Computerized Neurocognitive Battery (PennCNB) was adapted for use in Botswana. This study evaluated the criterion validity of a locally adapted version of the PennCNB among a cohort of HIV+ individuals aged 10–17 years in Botswana. Participants completed the PennCNB and a comprehensive professional consensus assessment consisting of pencil-and-paper psychological assessments, clinical interview, and review of academic performance. Seventy-two participants were classified as cases (i.e., with cognitive impairment; N = 48) or controls (i.e., without cognitive impairment; N = 24). Sensitivity, specificity, positive predictive value, negative predictive value, and the area under receiver operating characteristic curves were calculated. Discrimination was acceptable, and prediction improved as the threshold for PennCNB impairment was less conservative. This research contributes to the validation of the PennCNB for use among children affected by HIV in Botswana.",

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Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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