Predictors of C-reactive protein in Tsimane' 2 to 15 year-olds in lowland Bolivia

T. W. McDade*, W. R. Leonard, J. Burhop, V. Reyes-Garcìa, V. Vadez, T. Huanca, R. A. Godoy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Infectious disease is a major global determinant of child morbidity and mortality, and energetic investment in immune defenses (even in the absence of overt disease) is an important life-history variable, with implications for human growth and development. This study uses a biomarker of immune activation (C-reactive protein) to investigate an important aspect of child health among the Tsimane', a relatively isolated Amerindian population in lowland Bolivia. Our objectives are twofold: 1) to describe the distribution of CRP by age and gender in a cross-sectional sample of 536 2-15-year-olds; and 2) to explore multiple measures of pathogen exposure, economic resources, and acculturation as predictors of increased CRP. The median bloodspot CRP concentration was 0.73 mg/l, with 12.9% of the sample having concentrations greater than 5 mg/L, indicating a relatively high degree of immune activation in this population. Age was the strongest predictor of CRP, with the highest concentrations found among younger individuals. Increased CRP was also associated with higher pathogen exposure, lower household economic resources, and increased maternal education and literacy. The measurement of CRP offers a direct, objective indicator of immune activation, and provides insights into a potentially important pathway through which environmental quality may shape child growth and health.

Original languageEnglish (US)
Pages (from-to)906-913
Number of pages8
JournalAmerican Journal of Physical Anthropology
Volume128
Issue number4
DOIs
StatePublished - Dec 2005

Keywords

  • Acute-phase response
  • Bolivia
  • C-reactive protein
  • Growth and development
  • Infectious disease
  • Innate immunity

ASJC Scopus subject areas

  • Anatomy
  • Anthropology

Fingerprint Dive into the research topics of 'Predictors of C-reactive protein in Tsimane' 2 to 15 year-olds in lowland Bolivia'. Together they form a unique fingerprint.

Cite this