Abstract
Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-24.e3 |
| Journal | Archives of physical medicine and rehabilitation |
| Volume | 98 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
Keywords
- Aging
- Exercise
- Individuality
- Rehabilitation
- Resistance training
- Walking
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation
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Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity : The LIFE Study. / Layne, Andrew S.; Hsu, Fang Chi; Blair, Steven N.; Chen, Shyh Huei; Dungan, Jennifer; Fielding, Roger A.; Glynn, Nancy W.; Hajduk, Alexandra M.; King, Abby C.; Manini, Todd M.; Marsh, Anthony P.; Pahor, Marco; Pellegrini, Christine A.; Buford, Thomas W.; Pahor, Marco; Guralnik, Jack M.; Leeuwenburgh, Christiaan; Caudle, Connie; Crump, Lauren; Holmes, Latonia; Lee, Jocelyn; Lu, Ching ju; Miller, Michael E.; Espeland, Mark A.; Ambrosius, Walter T.; Applegate, William; Beavers, Daniel P.; Byington, Robert P.; Cook, Delilah; Furberg, Curt D.; Harvin, Lea N.; Henkin, Leora; Hepler, John; Hsu, Fang Chi; Lovato, Laura; Roberson, Wesley; Rushing, Julia; Rushing, Scott; Stowe, Cynthia L.; Walkup, Michael P.; Hire, Don; Rejeski, W. Jack; Katula, Jeffrey A.; Brubaker, Peter H.; Mihalko, Shannon L.; Jennings, Janine M.; Hadley, Evan C.; Romashkan, Sergei; Patel, Kushang V.; Bonds, Denise; McDermott, Mary M.; Spring, Bonnie; Hauser, Joshua; Kerwin, Diana; Domanchuk, Kathryn; Graff, Rex; Rego, Alvito; Church, Timothy S.; Blair, Steven N.; Myers, Valerie H.; Monce, Ron; Britt, Nathan E.; Harris, Melissa Nauta; McGucken, Ami Parks; Rodarte, Ruben; Millet, Heidi K.; Tudor-Locke, Catrine; Butitta, Ben P.; Donatto, Sheletta G.; Cocreham, Shannon H.; King, Abby C.; Castro, Cynthia M.; Haskell, William L.; Stafford, Randall S.; Pruitt, Leslie A.; Berra, Kathy; Yank, Veronica; Fielding, Roger A.; Nelson, Miriam E.; Folta, Sara C.; Phillips, Edward M.; Liu, Christine K.; McDavitt, Erica C.; Reid, Kieran F.; Kim, Won S.; Beard, Vince E.; Manini, Todd M.; Pahor, Marco; Anton, Stephen D.; Nayfield, Susan; Buford, Thomas W.; Marsiske, Michael; Sandesara, Bhanuprasad D.; Knaggs, Jeffrey D.; Lorow, Megan S.; Marena, William C.; Korytov, Irina; Morris, Holly L.; Fitch, Margo; Singletary, Floris F.; Causer, Jackie; Radcliff, Katie A.; Newman, Anne B.; Studenski, Stephanie A.; Goodpaster, Bret H.; Glynn, Nancy W.; Lopez, Oscar; Nadkarni, Neelesh K.; Williams, Kathy; Newman, Mark A.; Grove, George; Bonk, Janet T.; Rush, Jennifer; Kost, Piera; Ives, Diane G.; Kritchevsky, Stephen B.; Marsh, Anthony P.; Brinkley, Tina E.; Demons, Jamehl S.; Sink, Kaycee M.; Kennedy, Kimberly; Shertzer-Skinner, Rachel; Wrights, Abbie; Fries, Rose; Barr, Deborah; Gill, Thomas M.; Axtell, Robert S.; Kashaf, Susan S.; de Rekeneire, Nathalie; McGloin, Joanne M.; Wu, Karen C.; Shepard, Denise M.; Fennelly, Barbara; Iannone, Lynne P.; Mautner, Raeleen; Barnett, Theresa Sweeney; Halpin, Sean N.; Brennan, Matthew J.; Bugaj, Julie A.; Zenoni, Maria A.; Mignosa, Bridget M.; Williamson, Jeff; Sink, Kaycee M.; Hendrie, Hugh C.; Rapp, Stephen R.; Verghese, Joe; Woolard, Nancy; Espeland, Mark; Jennings, Janine; Pepine, Carl J.; Ariet, Mario; Handberg, Eileen; Deluca, Daniel; Hill, James; Szady, Anita; Chupp, Geoffrey L.; Flynn, Gail M.; Gill, Thomas M.; Hankinson, John L.; Vaz Fragoso, Carlos A.; Groessl, Erik J.; Kaplan, Robert M.
In: Archives of physical medicine and rehabilitation, Vol. 98, No. 1, 01.01.2017, p. 11-24.e3.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity
T2 - The LIFE Study
AU - Layne, Andrew S.
AU - Hsu, Fang Chi
AU - Blair, Steven N.
AU - Chen, Shyh Huei
AU - Dungan, Jennifer
AU - Fielding, Roger A.
AU - Glynn, Nancy W.
AU - Hajduk, Alexandra M.
AU - King, Abby C.
AU - Manini, Todd M.
AU - Marsh, Anthony P.
AU - Pahor, Marco
AU - Pellegrini, Christine A.
AU - Buford, Thomas W.
AU - Pahor, Marco
AU - Guralnik, Jack M.
AU - Leeuwenburgh, Christiaan
AU - Caudle, Connie
AU - Crump, Lauren
AU - Holmes, Latonia
AU - Lee, Jocelyn
AU - Lu, Ching ju
AU - Miller, Michael E.
AU - Espeland, Mark A.
AU - Ambrosius, Walter T.
AU - Applegate, William
AU - Beavers, Daniel P.
AU - Byington, Robert P.
AU - Cook, Delilah
AU - Furberg, Curt D.
AU - Harvin, Lea N.
AU - Henkin, Leora
AU - Hepler, John
AU - Hsu, Fang Chi
AU - Lovato, Laura
AU - Roberson, Wesley
AU - Rushing, Julia
AU - Rushing, Scott
AU - Stowe, Cynthia L.
AU - Walkup, Michael P.
AU - Hire, Don
AU - Rejeski, W. Jack
AU - Katula, Jeffrey A.
AU - Brubaker, Peter H.
AU - Mihalko, Shannon L.
AU - Jennings, Janine M.
AU - Hadley, Evan C.
AU - Romashkan, Sergei
AU - Patel, Kushang V.
AU - Bonds, Denise
AU - McDermott, Mary M.
AU - Spring, Bonnie
AU - Hauser, Joshua
AU - Kerwin, Diana
AU - Domanchuk, Kathryn
AU - Graff, Rex
AU - Rego, Alvito
AU - Church, Timothy S.
AU - Blair, Steven N.
AU - Myers, Valerie H.
AU - Monce, Ron
AU - Britt, Nathan E.
AU - Harris, Melissa Nauta
AU - McGucken, Ami Parks
AU - Rodarte, Ruben
AU - Millet, Heidi K.
AU - Tudor-Locke, Catrine
AU - Butitta, Ben P.
AU - Donatto, Sheletta G.
AU - Cocreham, Shannon H.
AU - King, Abby C.
AU - Castro, Cynthia M.
AU - Haskell, William L.
AU - Stafford, Randall S.
AU - Pruitt, Leslie A.
AU - Berra, Kathy
AU - Yank, Veronica
AU - Fielding, Roger A.
AU - Nelson, Miriam E.
AU - Folta, Sara C.
AU - Phillips, Edward M.
AU - Liu, Christine K.
AU - McDavitt, Erica C.
AU - Reid, Kieran F.
AU - Kim, Won S.
AU - Beard, Vince E.
AU - Manini, Todd M.
AU - Pahor, Marco
AU - Anton, Stephen D.
AU - Nayfield, Susan
AU - Buford, Thomas W.
AU - Marsiske, Michael
AU - Sandesara, Bhanuprasad D.
AU - Knaggs, Jeffrey D.
AU - Lorow, Megan S.
AU - Marena, William C.
AU - Korytov, Irina
AU - Morris, Holly L.
AU - Fitch, Margo
AU - Singletary, Floris F.
AU - Causer, Jackie
AU - Radcliff, Katie A.
AU - Newman, Anne B.
AU - Studenski, Stephanie A.
AU - Goodpaster, Bret H.
AU - Glynn, Nancy W.
AU - Lopez, Oscar
AU - Nadkarni, Neelesh K.
AU - Williams, Kathy
AU - Newman, Mark A.
AU - Grove, George
AU - Bonk, Janet T.
AU - Rush, Jennifer
AU - Kost, Piera
AU - Ives, Diane G.
AU - Kritchevsky, Stephen B.
AU - Marsh, Anthony P.
AU - Brinkley, Tina E.
AU - Demons, Jamehl S.
AU - Sink, Kaycee M.
AU - Kennedy, Kimberly
AU - Shertzer-Skinner, Rachel
AU - Wrights, Abbie
AU - Fries, Rose
AU - Barr, Deborah
AU - Gill, Thomas M.
AU - Axtell, Robert S.
AU - Kashaf, Susan S.
AU - de Rekeneire, Nathalie
AU - McGloin, Joanne M.
AU - Wu, Karen C.
AU - Shepard, Denise M.
AU - Fennelly, Barbara
AU - Iannone, Lynne P.
AU - Mautner, Raeleen
AU - Barnett, Theresa Sweeney
AU - Halpin, Sean N.
AU - Brennan, Matthew J.
AU - Bugaj, Julie A.
AU - Zenoni, Maria A.
AU - Mignosa, Bridget M.
AU - Williamson, Jeff
AU - Sink, Kaycee M.
AU - Hendrie, Hugh C.
AU - Rapp, Stephen R.
AU - Verghese, Joe
AU - Woolard, Nancy
AU - Espeland, Mark
AU - Jennings, Janine
AU - Pepine, Carl J.
AU - Ariet, Mario
AU - Handberg, Eileen
AU - Deluca, Daniel
AU - Hill, James
AU - Szady, Anita
AU - Chupp, Geoffrey L.
AU - Flynn, Gail M.
AU - Gill, Thomas M.
AU - Hankinson, John L.
AU - Vaz Fragoso, Carlos A.
AU - Groessl, Erik J.
AU - Kaplan, Robert M.
N1 - Funding Information: Supported by a National Institutes of Health/National Institute on Aging Cooperative Agreement (agreement no. U01 AG22376) and a supplement from the National Heart, Lung, and Blood Institute (grant no. 3U01AG022376-05A2S ) and sponsored in part by the Intramural Research Program, National Institute on Aging , National Institutes of Health . Also supported in part by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (grant no. 1 P30 AG028740 ), Tufts University (grant no. 1P30AG031679 ), University of Pittsburgh (grant no. P30 AG024827 ), Wake Forest University (grant no. P30AG021332 ), and Yale University (grant no. P30AG021342 ), the National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award at Stanford University (grant no. UL1 RR025744), the Boston Rehabilitation Outcomes Center (grant no. 1R24HD065688-01A1 ), and the National Institute on Aging (award no. K07AG3587), the Department of Veterans Affairs, and the U.S. Department of Agriculture (agreement no. 58-1950-0-014). Any opinions, findings, conclusion, or recommendations expressed in this article are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture. Publisher Copyright: © 2016 American Congress of Rehabilitation Medicine
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
AB - Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
KW - Aging
KW - Exercise
KW - Individuality
KW - Rehabilitation
KW - Resistance training
KW - Walking
UR - http://www.scopus.com/inward/record.url?scp=85005949399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85005949399&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2016.07.019
DO - 10.1016/j.apmr.2016.07.019
M3 - Article
C2 - 27568165
AN - SCOPUS:85005949399
VL - 98
SP - 11-24.e3
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 1
ER -