Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

Andrew S. Layne; Fang Chi Hsu; Steven N. Blair; Shyh Huei Chen; Jennifer Dungan; Roger A. Fielding; Nancy W. Glynn; Alexandra M. Hajduk; Abby C. King; Todd M. Manini; Anthony P. Marsh; Marco Pahor; Christine A. Pellegrini; Thomas W. Buford; Marco Pahor; Jack M. Guralnik; Christiaan Leeuwenburgh; Connie Caudle; Lauren Crump; Latonia Holmes; Jocelyn Lee; Ching ju Lu; Michael E. Miller; Mark A. Espeland; Walter T. Ambrosius; William Applegate; Daniel P. Beavers; Robert P. Byington; Delilah Cook; Curt D. Furberg; Lea N. Harvin; Leora Henkin; John Hepler; Fang Chi Hsu; Laura Lovato; Wesley Roberson; Julia Rushing; Scott Rushing; Cynthia L. Stowe; Michael P. Walkup; Don Hire; W. Jack Rejeski; Jeffrey A. Katula; Peter H. Brubaker; Shannon L. Mihalko; Janine M. Jennings; Evan C. Hadley; Sergei Romashkan; Kushang V. Patel; Denise Bonds; Mary M. McDermott; Bonnie Spring; Joshua Hauser; Diana Kerwin; Kathryn Domanchuk; Rex Graff; Alvito Rego; Timothy S. Church; Steven N. Blair; Valerie H. Myers; Ron Monce; Nathan E. Britt; Melissa Nauta Harris; Ami Parks McGucken; Ruben Rodarte; Heidi K. Millet; Catrine Tudor-Locke; Ben P. Butitta; Sheletta G. Donatto; Shannon H. Cocreham; Abby C. King; Cynthia M. Castro; William L. Haskell; Randall S. Stafford; Leslie A. Pruitt; Kathy Berra; Veronica Yank; Roger A. Fielding; Miriam E. Nelson; Sara C. Folta; Edward M. Phillips; Christine K. Liu; Erica C. McDavitt; Kieran F. Reid; Won S. Kim; Vince E. Beard; Todd M. Manini; Marco Pahor; Stephen D. Anton; Susan Nayfield; Thomas W. Buford; Michael Marsiske; Bhanuprasad D. Sandesara; Jeffrey D. Knaggs; Megan S. Lorow; William C. Marena; Irina Korytov; Holly L. Morris; Margo Fitch; Floris F. Singletary; Jackie Causer; Katie A. Radcliff; Anne B. Newman; Stephanie A. Studenski; Bret H. Goodpaster; Nancy W. Glynn; Oscar Lopez; Neelesh K. Nadkarni; Kathy Williams; Mark A. Newman; George Grove; Janet T. Bonk; Jennifer Rush; Piera Kost; Diane G. Ives; Stephen B. Kritchevsky; Anthony P. Marsh; Tina E. Brinkley; Jamehl S. Demons; Kaycee M. Sink; Kimberly Kennedy; Rachel Shertzer-Skinner; Abbie Wrights; Rose Fries; Deborah Barr; Thomas M. Gill; Robert S. Axtell; Susan S. Kashaf; Nathalie de Rekeneire; Joanne M. McGloin; Karen C. Wu; Denise M. Shepard; Barbara Fennelly; Lynne P. Iannone; Raeleen Mautner; Theresa Sweeney Barnett; Sean N. Halpin; Matthew J. Brennan; Julie A. Bugaj; Maria A. Zenoni; Bridget M. Mignosa; Jeff Williamson; Kaycee M. Sink; Hugh C. Hendrie; Stephen R. Rapp; Joe Verghese; Nancy Woolard; Mark Espeland; Janine Jennings; Carl J. Pepine; Mario Ariet; Eileen Handberg; Daniel Deluca; James Hill; Anita Szady; Geoffrey L. Chupp; Gail M. Flynn; Thomas M. Gill; John L. Hankinson; Carlos A. Vaz Fragoso; Erik J. Groessl; Robert M. Kaplan

doi:10.1016/j.apmr.2016.07.019

Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

Andrew S. Layne, Fang Chi Hsu, Steven N. Blair, Shyh Huei Chen, Jennifer Dungan, Roger A. Fielding, Nancy W. Glynn, Alexandra M. Hajduk, Abby C. King, Todd M. Manini, Anthony P. Marsh, Marco Pahor, Christine A. Pellegrini, Thomas W. Buford, Marco Pahor, Jack M. Guralnik, Christiaan Leeuwenburgh, Connie Caudle, Lauren Crump, Latonia HolmesJocelyn Lee, Ching ju Lu, Michael E. Miller, Mark A. Espeland, Walter T. Ambrosius, William Applegate, Daniel P. Beavers, Robert P. Byington, Delilah Cook, Curt D. Furberg, Lea N. Harvin, Leora Henkin, John Hepler, Fang Chi Hsu, Laura Lovato, Wesley Roberson, Julia Rushing, Scott Rushing, Cynthia L. Stowe, Michael P. Walkup, Don Hire, W. Jack Rejeski, Jeffrey A. Katula, Peter H. Brubaker, Shannon L. Mihalko, Janine M. Jennings, Evan C. Hadley, Sergei Romashkan, Kushang V. Patel, Denise Bonds, Mary M. McDermott, Bonnie Spring, Joshua Hauser, Diana Kerwin, Kathryn Domanchuk, Rex Graff, Alvito Rego, Timothy S. Church, Steven N. Blair, Valerie H. Myers, Ron Monce, Nathan E. Britt, Melissa Nauta Harris, Ami Parks McGucken, Ruben Rodarte, Heidi K. Millet, Catrine Tudor-Locke, Ben P. Butitta, Sheletta G. Donatto, Shannon H. Cocreham, Abby C. King, Cynthia M. Castro, William L. Haskell, Randall S. Stafford, Leslie A. Pruitt, Kathy Berra, Veronica Yank, Roger A. Fielding, Miriam E. Nelson, Sara C. Folta, Edward M. Phillips, Christine K. Liu, Erica C. McDavitt, Kieran F. Reid, Won S. Kim, Vince E. Beard, Todd M. Manini, Marco Pahor, Stephen D. Anton, Susan Nayfield, Thomas W. Buford, Michael Marsiske, Bhanuprasad D. Sandesara, Jeffrey D. Knaggs, Megan S. Lorow, William C. Marena, Irina Korytov, Holly L. Morris, Margo Fitch, Floris F. Singletary, Jackie Causer, Katie A. Radcliff, Anne B. Newman, Stephanie A. Studenski, Bret H. Goodpaster, Nancy W. Glynn, Oscar Lopez, Neelesh K. Nadkarni, Kathy Williams, Mark A. Newman, George Grove, Janet T. Bonk, Jennifer Rush, Piera Kost, Diane G. Ives, Stephen B. Kritchevsky, Anthony P. Marsh, Tina E. Brinkley, Jamehl S. Demons, Kaycee M. Sink, Kimberly Kennedy, Rachel Shertzer-Skinner, Abbie Wrights, Rose Fries, Deborah Barr, Thomas M. Gill, Robert S. Axtell, Susan S. Kashaf, Nathalie de Rekeneire, Joanne M. McGloin, Karen C. Wu, Denise M. Shepard, Barbara Fennelly, Lynne P. Iannone, Raeleen Mautner, Theresa Sweeney Barnett, Sean N. Halpin, Matthew J. Brennan, Julie A. Bugaj, Maria A. Zenoni, Bridget M. Mignosa, Jeff Williamson, Kaycee M. Sink, Hugh C. Hendrie, Stephen R. Rapp, Joe Verghese, Nancy Woolard, Mark Espeland, Janine Jennings, Carl J. Pepine, Mario Ariet, Eileen Handberg, Daniel Deluca, James Hill, Anita Szady, Geoffrey L. Chupp, Gail M. Flynn, Thomas M. Gill, John L. Hankinson, Carlos A. Vaz Fragoso, Erik J. Groessl, Robert M. Kaplan

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.

Original language	English (US)
Pages (from-to)	11-24.e3
Journal	Archives of physical medicine and rehabilitation
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/j.apmr.2016.07.019
State	Published - Jan 1 2017

Funding

Supported by a National Institutes of Health/National Institute on Aging Cooperative Agreement (agreement no. U01 AG22376) and a supplement from the National Heart, Lung, and Blood Institute (grant no. 3U01AG022376-05A2S) and sponsored in part by the Intramural Research Program, National Institute on Aging, National Institutes of Health. Also supported in part by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (grant no. 1 P30 AG028740), Tufts University (grant no. 1P30AG031679), University of Pittsburgh (grant no. P30 AG024827), Wake Forest University (grant no. P30AG021332), and Yale University (grant no. P30AG021342), the National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award at Stanford University (grant no. UL1 RR025744), the Boston Rehabilitation Outcomes Center (grant no. 1R24HD065688-01A1), and the National Institute on Aging (award no. K07AG3587), the Department of Veterans Affairs, and the U.S. Department of Agriculture (agreement no. 58-1950-0-014). Any opinions, findings, conclusion, or recommendations expressed in this article are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture. The article \u201CPredictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study\u201D (Layne et al, Arch Phys Med Rehabil 2017;98:11-24) was also supported in part by the Yale Training Program in Geriatric Clinical Epidemiology and Aging-Related Research (National Institute on Aging T32AG019134).

Keywords

Aging
Exercise
Individuality
Rehabilitation
Resistance training
Walking

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

Access to Document

10.1016/j.apmr.2016.07.019

Cite this

Layne, A. S., Hsu, F. C., Blair, S. N., Chen, S. H., Dungan, J., Fielding, R. A., Glynn, N. W., Hajduk, A. M., King, A. C., Manini, T. M., Marsh, A. P., Pahor, M., Pellegrini, C. A., Buford, T. W., Pahor, M., Guralnik, J. M., Leeuwenburgh, C., Caudle, C., Crump, L., ... Kaplan, R. M. (2017). Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study. Archives of physical medicine and rehabilitation, 98(1), 11-24.e3. https://doi.org/10.1016/j.apmr.2016.07.019

@article{24900b31028e4eb6932b99e47893b387,

title = "Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study",

abstract = "Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.",

keywords = "Aging, Exercise, Individuality, Rehabilitation, Resistance training, Walking",

author = "Layne, {Andrew S.} and Hsu, {Fang Chi} and Blair, {Steven N.} and Chen, {Shyh Huei} and Jennifer Dungan and Fielding, {Roger A.} and Glynn, {Nancy W.} and Hajduk, {Alexandra M.} and King, {Abby C.} and Manini, {Todd M.} and Marsh, {Anthony P.} and Marco Pahor and Pellegrini, {Christine A.} and Buford, {Thomas W.} and Marco Pahor and Guralnik, {Jack M.} and Christiaan Leeuwenburgh and Connie Caudle and Lauren Crump and Latonia Holmes and Jocelyn Lee and Lu, {Ching ju} and Miller, {Michael E.} and Espeland, {Mark A.} and Ambrosius, {Walter T.} and William Applegate and Beavers, {Daniel P.} and Byington, {Robert P.} and Delilah Cook and Furberg, {Curt D.} and Harvin, {Lea N.} and Leora Henkin and John Hepler and Hsu, {Fang Chi} and Laura Lovato and Wesley Roberson and Julia Rushing and Scott Rushing and Stowe, {Cynthia L.} and Walkup, {Michael P.} and Don Hire and Rejeski, {W. Jack} and Katula, {Jeffrey A.} and Brubaker, {Peter H.} and Mihalko, {Shannon L.} and Jennings, {Janine M.} and Hadley, {Evan C.} and Sergei Romashkan and Patel, {Kushang V.} and Denise Bonds and McDermott, {Mary M.} and Bonnie Spring and Joshua Hauser and Diana Kerwin and Kathryn Domanchuk and Rex Graff and Alvito Rego and Church, {Timothy S.} and Blair, {Steven N.} and Myers, {Valerie H.} and Ron Monce and Britt, {Nathan E.} and Harris, {Melissa Nauta} and McGucken, {Ami Parks} and Ruben Rodarte and Millet, {Heidi K.} and Catrine Tudor-Locke and Butitta, {Ben P.} and Donatto, {Sheletta G.} and Cocreham, {Shannon H.} and King, {Abby C.} and Castro, {Cynthia M.} and Haskell, {William L.} and Stafford, {Randall S.} and Pruitt, {Leslie A.} and Kathy Berra and Veronica Yank and Fielding, {Roger A.} and Nelson, {Miriam E.} and Folta, {Sara C.} and Phillips, {Edward M.} and Liu, {Christine K.} and McDavitt, {Erica C.} and Reid, {Kieran F.} and Kim, {Won S.} and Beard, {Vince E.} and Manini, {Todd M.} and Marco Pahor and Anton, {Stephen D.} and Susan Nayfield and Buford, {Thomas W.} and Michael Marsiske and Sandesara, {Bhanuprasad D.} and Knaggs, {Jeffrey D.} and Lorow, {Megan S.} and Marena, {William C.} and Irina Korytov and Morris, {Holly L.} and Margo Fitch and Singletary, {Floris F.} and Jackie Causer and Radcliff, {Katie A.} and Newman, {Anne B.} and Studenski, {Stephanie A.} and Goodpaster, {Bret H.} and Glynn, {Nancy W.} and Oscar Lopez and Nadkarni, {Neelesh K.} and Kathy Williams and Newman, {Mark A.} and George Grove and Bonk, {Janet T.} and Jennifer Rush and Piera Kost and Ives, {Diane G.} and Kritchevsky, {Stephen B.} and Marsh, {Anthony P.} and Brinkley, {Tina E.} and Demons, {Jamehl S.} and Sink, {Kaycee M.} and Kimberly Kennedy and Rachel Shertzer-Skinner and Abbie Wrights and Rose Fries and Deborah Barr and Gill, {Thomas M.} and Axtell, {Robert S.} and Kashaf, {Susan S.} and {de Rekeneire}, Nathalie and McGloin, {Joanne M.} and Wu, {Karen C.} and Shepard, {Denise M.} and Barbara Fennelly and Iannone, {Lynne P.} and Raeleen Mautner and Barnett, {Theresa Sweeney} and Halpin, {Sean N.} and Brennan, {Matthew J.} and Bugaj, {Julie A.} and Zenoni, {Maria A.} and Mignosa, {Bridget M.} and Jeff Williamson and Sink, {Kaycee M.} and Hendrie, {Hugh C.} and Rapp, {Stephen R.} and Joe Verghese and Nancy Woolard and Mark Espeland and Janine Jennings and Pepine, {Carl J.} and Mario Ariet and Eileen Handberg and Daniel Deluca and James Hill and Anita Szady and Chupp, {Geoffrey L.} and Flynn, {Gail M.} and Gill, {Thomas M.} and Hankinson, {John L.} and {Vaz Fragoso}, {Carlos A.} and Groessl, {Erik J.} and Kaplan, {Robert M.}",

note = "Funding Information: Supported by a National Institutes of Health/National Institute on Aging Cooperative Agreement (agreement no. U01 AG22376) and a supplement from the National Heart, Lung, and Blood Institute (grant no. 3U01AG022376-05A2S ) and sponsored in part by the Intramural Research Program, National Institute on Aging , National Institutes of Health . Also supported in part by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (grant no. 1 P30 AG028740 ), Tufts University (grant no. 1P30AG031679 ), University of Pittsburgh (grant no. P30 AG024827 ), Wake Forest University (grant no. P30AG021332 ), and Yale University (grant no. P30AG021342 ), the National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award at Stanford University (grant no. UL1 RR025744), the Boston Rehabilitation Outcomes Center (grant no. 1R24HD065688-01A1 ), and the National Institute on Aging (award no. K07AG3587), the Department of Veterans Affairs, and the U.S. Department of Agriculture (agreement no. 58-1950-0-014). Any opinions, findings, conclusion, or recommendations expressed in this article are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture. Publisher Copyright: {\textcopyright} 2016 American Congress of Rehabilitation Medicine",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.apmr.2016.07.019",

language = "English (US)",

volume = "98",

pages = "11--24.e3",

journal = "Archives of physical medicine and rehabilitation",

issn = "0003-9993",

publisher = "W.B. Saunders",

number = "1",

}

Layne, AS, Hsu, FC, Blair, SN, Chen, SH, Dungan, J, Fielding, RA, Glynn, NW, Hajduk, AM, King, AC, Manini, TM, Marsh, AP, Pahor, M, Pellegrini, CA, Buford, TW, Pahor, M, Guralnik, JM, Leeuwenburgh, C, Caudle, C, Crump, L, Holmes, L, Lee, J, Lu, CJ, Miller, ME, Espeland, MA, Ambrosius, WT, Applegate, W, Beavers, DP, Byington, RP, Cook, D, Furberg, CD, Harvin, LN, Henkin, L, Hepler, J, Hsu, FC, Lovato, L, Roberson, W, Rushing, J, Rushing, S, Stowe, CL, Walkup, MP, Hire, D, Rejeski, WJ, Katula, JA, Brubaker, PH, Mihalko, SL, Jennings, JM, Hadley, EC, Romashkan, S, Patel, KV, Bonds, D, McDermott, MM, Spring, B, Hauser, J, Kerwin, D, Domanchuk, K, Graff, R, Rego, A, Church, TS, Blair, SN, Myers, VH, Monce, R, Britt, NE, Harris, MN, McGucken, AP, Rodarte, R, Millet, HK, Tudor-Locke, C, Butitta, BP, Donatto, SG, Cocreham, SH, King, AC, Castro, CM, Haskell, WL, Stafford, RS, Pruitt, LA, Berra, K, Yank, V, Fielding, RA, Nelson, ME, Folta, SC, Phillips, EM, Liu, CK, McDavitt, EC, Reid, KF, Kim, WS, Beard, VE, Manini, TM, Pahor, M, Anton, SD, Nayfield, S, Buford, TW, Marsiske, M, Sandesara, BD, Knaggs, JD, Lorow, MS, Marena, WC, Korytov, I, Morris, HL, Fitch, M, Singletary, FF, Causer, J, Radcliff, KA, Newman, AB, Studenski, SA, Goodpaster, BH, Glynn, NW, Lopez, O, Nadkarni, NK, Williams, K, Newman, MA, Grove, G, Bonk, JT, Rush, J, Kost, P, Ives, DG, Kritchevsky, SB, Marsh, AP, Brinkley, TE, Demons, JS, Sink, KM, Kennedy, K, Shertzer-Skinner, R, Wrights, A, Fries, R, Barr, D, Gill, TM, Axtell, RS, Kashaf, SS, de Rekeneire, N, McGloin, JM, Wu, KC, Shepard, DM, Fennelly, B, Iannone, LP, Mautner, R, Barnett, TS, Halpin, SN, Brennan, MJ, Bugaj, JA, Zenoni, MA, Mignosa, BM, Williamson, J, Sink, KM, Hendrie, HC, Rapp, SR, Verghese, J, Woolard, N, Espeland, M, Jennings, J, Pepine, CJ, Ariet, M, Handberg, E, Deluca, D, Hill, J, Szady, A, Chupp, GL, Flynn, GM, Gill, TM, Hankinson, JL, Vaz Fragoso, CA, Groessl, EJ & Kaplan, RM 2017, 'Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study', Archives of physical medicine and rehabilitation, vol. 98, no. 1, pp. 11-24.e3. https://doi.org/10.1016/j.apmr.2016.07.019

TY - JOUR

T1 - Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity

T2 - The LIFE Study

AU - Layne, Andrew S.

AU - Hsu, Fang Chi

AU - Blair, Steven N.

AU - Chen, Shyh Huei

AU - Dungan, Jennifer

AU - Fielding, Roger A.

AU - Glynn, Nancy W.

AU - Hajduk, Alexandra M.

AU - King, Abby C.

AU - Manini, Todd M.

AU - Marsh, Anthony P.

AU - Pahor, Marco

AU - Pellegrini, Christine A.

AU - Buford, Thomas W.

AU - Pahor, Marco

AU - Guralnik, Jack M.

AU - Leeuwenburgh, Christiaan

AU - Caudle, Connie

AU - Crump, Lauren

AU - Holmes, Latonia

AU - Lee, Jocelyn

AU - Lu, Ching ju

AU - Miller, Michael E.

AU - Espeland, Mark A.

AU - Ambrosius, Walter T.

AU - Applegate, William

AU - Beavers, Daniel P.

AU - Byington, Robert P.

AU - Cook, Delilah

AU - Furberg, Curt D.

AU - Harvin, Lea N.

AU - Henkin, Leora

AU - Hepler, John

AU - Hsu, Fang Chi

AU - Lovato, Laura

AU - Roberson, Wesley

AU - Rushing, Julia

AU - Rushing, Scott

AU - Stowe, Cynthia L.

AU - Walkup, Michael P.

AU - Hire, Don

AU - Rejeski, W. Jack

AU - Katula, Jeffrey A.

AU - Brubaker, Peter H.

AU - Mihalko, Shannon L.

AU - Jennings, Janine M.

AU - Hadley, Evan C.

AU - Romashkan, Sergei

AU - Patel, Kushang V.

AU - Bonds, Denise

AU - McDermott, Mary M.

AU - Spring, Bonnie

AU - Hauser, Joshua

AU - Kerwin, Diana

AU - Domanchuk, Kathryn

AU - Graff, Rex

AU - Rego, Alvito

AU - Church, Timothy S.

AU - Blair, Steven N.

AU - Myers, Valerie H.

AU - Monce, Ron

AU - Britt, Nathan E.

AU - Harris, Melissa Nauta

AU - McGucken, Ami Parks

AU - Rodarte, Ruben

AU - Millet, Heidi K.

AU - Tudor-Locke, Catrine

AU - Butitta, Ben P.

AU - Donatto, Sheletta G.

AU - Cocreham, Shannon H.

AU - King, Abby C.

AU - Castro, Cynthia M.

AU - Haskell, William L.

AU - Stafford, Randall S.

AU - Pruitt, Leslie A.

AU - Berra, Kathy

AU - Yank, Veronica

AU - Fielding, Roger A.

AU - Nelson, Miriam E.

AU - Folta, Sara C.

AU - Phillips, Edward M.

AU - Liu, Christine K.

AU - McDavitt, Erica C.

AU - Reid, Kieran F.

AU - Kim, Won S.

AU - Beard, Vince E.

AU - Manini, Todd M.

AU - Pahor, Marco

AU - Anton, Stephen D.

AU - Nayfield, Susan

AU - Buford, Thomas W.

AU - Marsiske, Michael

AU - Sandesara, Bhanuprasad D.

AU - Knaggs, Jeffrey D.

AU - Lorow, Megan S.

AU - Marena, William C.

AU - Korytov, Irina

AU - Morris, Holly L.

AU - Fitch, Margo

AU - Singletary, Floris F.

AU - Causer, Jackie

AU - Radcliff, Katie A.

AU - Newman, Anne B.

AU - Studenski, Stephanie A.

AU - Goodpaster, Bret H.

AU - Glynn, Nancy W.

AU - Lopez, Oscar

AU - Nadkarni, Neelesh K.

AU - Williams, Kathy

AU - Newman, Mark A.

AU - Grove, George

AU - Bonk, Janet T.

AU - Rush, Jennifer

AU - Kost, Piera

AU - Ives, Diane G.

AU - Kritchevsky, Stephen B.

AU - Marsh, Anthony P.

AU - Brinkley, Tina E.

AU - Demons, Jamehl S.

AU - Sink, Kaycee M.

AU - Kennedy, Kimberly

AU - Shertzer-Skinner, Rachel

AU - Wrights, Abbie

AU - Fries, Rose

AU - Barr, Deborah

AU - Gill, Thomas M.

AU - Axtell, Robert S.

AU - Kashaf, Susan S.

AU - de Rekeneire, Nathalie

AU - McGloin, Joanne M.

AU - Wu, Karen C.

AU - Shepard, Denise M.

AU - Fennelly, Barbara

AU - Iannone, Lynne P.

AU - Mautner, Raeleen

AU - Barnett, Theresa Sweeney

AU - Halpin, Sean N.

AU - Brennan, Matthew J.

AU - Bugaj, Julie A.

AU - Zenoni, Maria A.

AU - Mignosa, Bridget M.

AU - Williamson, Jeff

AU - Sink, Kaycee M.

AU - Hendrie, Hugh C.

AU - Rapp, Stephen R.

AU - Verghese, Joe

AU - Woolard, Nancy

AU - Espeland, Mark

AU - Jennings, Janine

AU - Pepine, Carl J.

AU - Ariet, Mario

AU - Handberg, Eileen

AU - Deluca, Daniel

AU - Hill, James

AU - Szady, Anita

AU - Chupp, Geoffrey L.

AU - Flynn, Gail M.

AU - Gill, Thomas M.

AU - Hankinson, John L.

AU - Vaz Fragoso, Carlos A.

AU - Groessl, Erik J.

AU - Kaplan, Robert M.

N1 - Funding Information: Supported by a National Institutes of Health/National Institute on Aging Cooperative Agreement (agreement no. U01 AG22376) and a supplement from the National Heart, Lung, and Blood Institute (grant no. 3U01AG022376-05A2S ) and sponsored in part by the Intramural Research Program, National Institute on Aging , National Institutes of Health . Also supported in part by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (grant no. 1 P30 AG028740 ), Tufts University (grant no. 1P30AG031679 ), University of Pittsburgh (grant no. P30 AG024827 ), Wake Forest University (grant no. P30AG021332 ), and Yale University (grant no. P30AG021342 ), the National Institutes of Health/National Center for Research Resources Clinical and Translational Science Award at Stanford University (grant no. UL1 RR025744), the Boston Rehabilitation Outcomes Center (grant no. 1R24HD065688-01A1 ), and the National Institute on Aging (award no. K07AG3587), the Department of Veterans Affairs, and the U.S. Department of Agriculture (agreement no. 58-1950-0-014). Any opinions, findings, conclusion, or recommendations expressed in this article are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture. Publisher Copyright: © 2016 American Congress of Rehabilitation Medicine

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.

AB - Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.

KW - Aging

KW - Exercise

KW - Individuality

KW - Rehabilitation

KW - Resistance training

KW - Walking

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U2 - 10.1016/j.apmr.2016.07.019

DO - 10.1016/j.apmr.2016.07.019

M3 - Article

C2 - 27568165

AN - SCOPUS:85005949399

SN - 0003-9993

VL - 98

SP - 11-24.e3

JO - Archives of physical medicine and rehabilitation

JF - Archives of physical medicine and rehabilitation

IS - 1

ER -

Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

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