Abstract
Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 11-24.e3 |
| Journal | Archives of physical medicine and rehabilitation |
| Volume | 98 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
Keywords
- Aging
- Exercise
- Individuality
- Rehabilitation
- Resistance training
- Walking
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation
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Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity : The LIFE Study. / Layne, Andrew S.; Hsu, Fang Chi; Blair, Steven N.; Chen, Shyh Huei; Dungan, Jennifer; Fielding, Roger A.; Glynn, Nancy W.; Hajduk, Alexandra M.; King, Abby C.; Manini, Todd M.; Marsh, Anthony P.; Pahor, Marco; Pellegrini, Christine A.; Buford, Thomas W.; Pahor, Marco; Guralnik, Jack M.; Leeuwenburgh, Christiaan; Caudle, Connie; Crump, Lauren; Holmes, Latonia; Lee, Jocelyn; Lu, Ching ju; Miller, Michael E.; Espeland, Mark A.; Ambrosius, Walter T.; Applegate, William; Beavers, Daniel P.; Byington, Robert P.; Cook, Delilah; Furberg, Curt D.; Harvin, Lea N.; Henkin, Leora; Hepler, John; Hsu, Fang Chi; Lovato, Laura; Roberson, Wesley; Rushing, Julia; Rushing, Scott; Stowe, Cynthia L.; Walkup, Michael P.; Hire, Don; Rejeski, W. Jack; Katula, Jeffrey A.; Brubaker, Peter H.; Mihalko, Shannon L.; Jennings, Janine M.; Hadley, Evan C.; Romashkan, Sergei; Patel, Kushang V.; Bonds, Denise; McDermott, Mary M.; Spring, Bonnie; Hauser, Joshua; Kerwin, Diana; Domanchuk, Kathryn; Graff, Rex; Rego, Alvito; Church, Timothy S.; Blair, Steven N.; Myers, Valerie H.; Monce, Ron; Britt, Nathan E.; Harris, Melissa Nauta; McGucken, Ami Parks; Rodarte, Ruben; Millet, Heidi K.; Tudor-Locke, Catrine; Butitta, Ben P.; Donatto, Sheletta G.; Cocreham, Shannon H.; King, Abby C.; Castro, Cynthia M.; Haskell, William L.; Stafford, Randall S.; Pruitt, Leslie A.; Berra, Kathy; Yank, Veronica; Fielding, Roger A.; Nelson, Miriam E.; Folta, Sara C.; Phillips, Edward M.; Liu, Christine K.; McDavitt, Erica C.; Reid, Kieran F.; Kim, Won S.; Beard, Vince E.; Manini, Todd M.; Pahor, Marco; Anton, Stephen D.; Nayfield, Susan; Buford, Thomas W.; Marsiske, Michael; Sandesara, Bhanuprasad D.; Knaggs, Jeffrey D.; Lorow, Megan S.; Marena, William C.; Korytov, Irina; Morris, Holly L.; Fitch, Margo; Singletary, Floris F.; Causer, Jackie; Radcliff, Katie A.; Newman, Anne B.; Studenski, Stephanie A.; Goodpaster, Bret H.; Glynn, Nancy W.; Lopez, Oscar; Nadkarni, Neelesh K.; Williams, Kathy; Newman, Mark A.; Grove, George; Bonk, Janet T.; Rush, Jennifer; Kost, Piera; Ives, Diane G.; Kritchevsky, Stephen B.; Marsh, Anthony P.; Brinkley, Tina E.; Demons, Jamehl S.; Sink, Kaycee M.; Kennedy, Kimberly; Shertzer-Skinner, Rachel; Wrights, Abbie; Fries, Rose; Barr, Deborah; Gill, Thomas M.; Axtell, Robert S.; Kashaf, Susan S.; de Rekeneire, Nathalie; McGloin, Joanne M.; Wu, Karen C.; Shepard, Denise M.; Fennelly, Barbara; Iannone, Lynne P.; Mautner, Raeleen; Barnett, Theresa Sweeney; Halpin, Sean N.; Brennan, Matthew J.; Bugaj, Julie A.; Zenoni, Maria A.; Mignosa, Bridget M.; Williamson, Jeff; Sink, Kaycee M.; Hendrie, Hugh C.; Rapp, Stephen R.; Verghese, Joe; Woolard, Nancy; Espeland, Mark; Jennings, Janine; Pepine, Carl J.; Ariet, Mario; Handberg, Eileen; Deluca, Daniel; Hill, James; Szady, Anita; Chupp, Geoffrey L.; Flynn, Gail M.; Gill, Thomas M.; Hankinson, John L.; Vaz Fragoso, Carlos A.; Groessl, Erik J.; Kaplan, Robert M.
In: Archives of physical medicine and rehabilitation, Vol. 98, No. 1, 01.01.2017, p. 11-24.e3.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity
T2 - The LIFE Study
AU - Layne, Andrew S.
AU - Hsu, Fang Chi
AU - Blair, Steven N.
AU - Chen, Shyh Huei
AU - Dungan, Jennifer
AU - Fielding, Roger A.
AU - Glynn, Nancy W.
AU - Hajduk, Alexandra M.
AU - King, Abby C.
AU - Manini, Todd M.
AU - Marsh, Anthony P.
AU - Pahor, Marco
AU - Pellegrini, Christine A.
AU - Buford, Thomas W.
AU - Pahor, Marco
AU - Guralnik, Jack M.
AU - Leeuwenburgh, Christiaan
AU - Caudle, Connie
AU - Crump, Lauren
AU - Holmes, Latonia
AU - Lee, Jocelyn
AU - Lu, Ching ju
AU - Miller, Michael E.
AU - Espeland, Mark A.
AU - Ambrosius, Walter T.
AU - Applegate, William
AU - Beavers, Daniel P.
AU - Byington, Robert P.
AU - Cook, Delilah
AU - Furberg, Curt D.
AU - Harvin, Lea N.
AU - Henkin, Leora
AU - Hepler, John
AU - Hsu, Fang Chi
AU - Lovato, Laura
AU - Roberson, Wesley
AU - Rushing, Julia
AU - Rushing, Scott
AU - Stowe, Cynthia L.
AU - Walkup, Michael P.
AU - Hire, Don
AU - Rejeski, W. Jack
AU - Katula, Jeffrey A.
AU - Brubaker, Peter H.
AU - Mihalko, Shannon L.
AU - Jennings, Janine M.
AU - Hadley, Evan C.
AU - Romashkan, Sergei
AU - Patel, Kushang V.
AU - Bonds, Denise
AU - McDermott, Mary M.
AU - Spring, Bonnie
AU - Hauser, Joshua
AU - Kerwin, Diana
AU - Domanchuk, Kathryn
AU - Graff, Rex
AU - Rego, Alvito
AU - Church, Timothy S.
AU - Blair, Steven N.
AU - Myers, Valerie H.
AU - Monce, Ron
AU - Britt, Nathan E.
AU - Harris, Melissa Nauta
AU - McGucken, Ami Parks
AU - Rodarte, Ruben
AU - Millet, Heidi K.
AU - Tudor-Locke, Catrine
AU - Butitta, Ben P.
AU - Donatto, Sheletta G.
AU - Cocreham, Shannon H.
AU - King, Abby C.
AU - Castro, Cynthia M.
AU - Haskell, William L.
AU - Stafford, Randall S.
AU - Pruitt, Leslie A.
AU - Berra, Kathy
AU - Yank, Veronica
AU - Fielding, Roger A.
AU - Nelson, Miriam E.
AU - Folta, Sara C.
AU - Phillips, Edward M.
AU - Liu, Christine K.
AU - McDavitt, Erica C.
AU - Reid, Kieran F.
AU - Kim, Won S.
AU - Beard, Vince E.
AU - Manini, Todd M.
AU - Pahor, Marco
AU - Anton, Stephen D.
AU - Nayfield, Susan
AU - Buford, Thomas W.
AU - Marsiske, Michael
AU - Sandesara, Bhanuprasad D.
AU - Knaggs, Jeffrey D.
AU - Lorow, Megan S.
AU - Marena, William C.
AU - Korytov, Irina
AU - Morris, Holly L.
AU - Fitch, Margo
AU - Singletary, Floris F.
AU - Causer, Jackie
AU - Radcliff, Katie A.
AU - Newman, Anne B.
AU - Studenski, Stephanie A.
AU - Goodpaster, Bret H.
AU - Glynn, Nancy W.
AU - Lopez, Oscar
AU - Nadkarni, Neelesh K.
AU - Williams, Kathy
AU - Newman, Mark A.
AU - Grove, George
AU - Bonk, Janet T.
AU - Rush, Jennifer
AU - Kost, Piera
AU - Ives, Diane G.
AU - Kritchevsky, Stephen B.
AU - Marsh, Anthony P.
AU - Brinkley, Tina E.
AU - Demons, Jamehl S.
AU - Sink, Kaycee M.
AU - Kennedy, Kimberly
AU - Shertzer-Skinner, Rachel
AU - Wrights, Abbie
AU - Fries, Rose
AU - Barr, Deborah
AU - Gill, Thomas M.
AU - Axtell, Robert S.
AU - Kashaf, Susan S.
AU - de Rekeneire, Nathalie
AU - McGloin, Joanne M.
AU - Wu, Karen C.
AU - Shepard, Denise M.
AU - Fennelly, Barbara
AU - Iannone, Lynne P.
AU - Mautner, Raeleen
AU - Barnett, Theresa Sweeney
AU - Halpin, Sean N.
AU - Brennan, Matthew J.
AU - Bugaj, Julie A.
AU - Zenoni, Maria A.
AU - Mignosa, Bridget M.
AU - Williamson, Jeff
AU - Sink, Kaycee M.
AU - Hendrie, Hugh C.
AU - Rapp, Stephen R.
AU - Verghese, Joe
AU - Woolard, Nancy
AU - Espeland, Mark
AU - Jennings, Janine
AU - Pepine, Carl J.
AU - Ariet, Mario
AU - Handberg, Eileen
AU - Deluca, Daniel
AU - Hill, James
AU - Szady, Anita
AU - Chupp, Geoffrey L.
AU - Flynn, Gail M.
AU - Gill, Thomas M.
AU - Hankinson, John L.
AU - Vaz Fragoso, Carlos A.
AU - Groessl, Erik J.
AU - Kaplan, Robert M.
N1 - Funding Information: The LIFE Study investigators and their location are: Administrative Coordinating Center, University of Florida, Gainesville, FL Marco Pahor, MD, Principal Investigator of the LIFE Study Jack M. Guralnik, MD, PhD, Co-Investigator of the LIFE Study (University of Maryland School of Medicine, Baltimore, MD) Christiaan Leeuwenburgh, PhD Connie Caudle Lauren Crump, MPH Latonia Holmes Jocelyn Lee, PhD Ching-ju Lu, MPH Data Management, Analysis and Quality Control Center (DMAQC), Wake Forest University, Winston Salem, NC Michael E. Miller, PhD, DMAQC Principal Investigator Mark A. Espeland, PhD, DMAQC Co-Investigator Walter T. Ambrosius, PhD William Applegate, MD Daniel P. Beavers, PhD, MS Robert P. Byington, PhD, MPH, FAHA Delilah Cook, CCRP Curt D. Furberg, MD, PhD Lea N. Harvin, BS Leora Henkin, MPH, MEd John Hepler, MA Fang-Chi Hsu, PhD Laura Lovato, MS Wesley Roberson, BSBA Julia Rushing, BSPH, MStat Scott Rushing, BS Cynthia L. Stowe, MPM Michael P. Walkup, MS Don Hire, BS W. Jack Rejeski, PhD Jeffrey A. Katula, PhD, MA Peter H. Brubaker, PhD Shannon L. Mihalko, PhD Janine M. Jennings, PhD National Institute on Aging, Bethesda, MD Evan C. Hadley, MD (National Institute on Aging) Sergei Romashkan, MD, PhD (National Institute on Aging) Kushang V. Patel, PhD (National Institute on Aging) National Heart, Lung, and Blood Institute, Bethesda, MD Denise Bonds, MD, MPH Field Centers Northwestern University, Chicago, IL Mary M. McDermott, MD, Field Center Principal Investigator Bonnie Spring, PhD, Field Center Co-Investigator Joshua Hauser, MD, Field Center Co-Investigator Diana Kerwin, MD, Field Center Co-Investigator Kathryn Domanchuk, BS Rex Graff, MS Alvito Rego, MA Pennington Biomedical Research Center, Baton Rouge, LA Timothy S. Church, MD, PhD, MPH, Field Center Principal Investigator Steven N. Blair, PED (University of South Carolina, Columbia, SC) Valerie H. Myers, PhD Ron Monce, PA-C Nathan E. Britt, NP Melissa Nauta Harris, BS Ami Parks McGucken, MPA, BS Ruben Rodarte, MBA, MS, BS Heidi K. Millet, MPA, BS Catrine Tudor-Locke, PhD, FACSM Ben P. Butitta, BS Sheletta G. Donatto, MS, RD, LDN, CDE Shannon H. Cocreham, BS Stanford University, Palo Alto, CA Abby C. King, PhD, Field Center Principal Investigator Cynthia M. Castro, PhD William L. Haskell, PhD Randall S. Stafford, MD, PhD Leslie A. Pruitt, PhD Kathy Berra, MSN, NP-C, FAAN Veronica Yank, MD Tufts University, Boston, MA Roger A. Fielding, PhD, Field Center Principal Investigator Miriam E. Nelson, PhD, Field Center Co-Investigator Sara C. Folta, PhD, Field Center Co-Investigator Edward M. Phillips, MD Christine K. Liu, MD Erica C. McDavitt, MS Kieran F. Reid, PhD, MPH Won S. Kim, BS Vince E. Beard, BS University of Florida, Gainesville, FL Todd M. Manini, PhD, Field Center Principal Investigator Marco Pahor, MD, Field Center Co-Investigator Stephen D. Anton, PhD Susan Nayfield, MD Thomas W. Buford, PhD Michael Marsiske, PhD Bhanuprasad D. Sandesara, MD Jeffrey D. Knaggs, BS Megan S. Lorow, BS William C. Marena, MT, CCRC Irina Korytov, MD Holly L. Morris, MSN, RN, CCRC (Brooks Rehabilitation Clinical Research Center, Jacksonville, FL) Margo Fitch, PT (Brooks Rehabilitation Clinical Research Center, Jacksonville, FL) Floris F. Singletary, MS, CCC-SLP (Brooks Rehabilitation Clinical Research Center, Jacksonville, FL) Jackie Causer, BSH, RN (Brooks Rehabilitation Clinical Research Center, Jacksonville, FL) Katie A. Radcliff, MA (Brooks Rehabilitation Clinical Research Center, Jacksonville, FL) University of Pittsburgh, Pittsburgh, PA Anne B. Newman, MD, MPH, Field Center Principal Investigator Stephanie A. Studenski, MD, MPH, Field Center Co-Investigator Bret H. Goodpaster, PhD Nancy W. Glynn, PhD Oscar Lopez, MD Neelesh K. Nadkarni, MD, PhD Kathy Williams, RN, BSEd, MHSA Mark A. Newman, PhD George Grove, MS Janet T. Bonk, MPH, RN Jennifer Rush, MPH Piera Kost, BA (deceased) Diane G. Ives, MPH Wake Forest University, Winston Salem, NC Stephen B. Kritchevsky, PhD, Field Center Principal Investigator Anthony P. Marsh, PhD, Field Center Co-Investigator Tina E. Brinkley, PhD Jamehl S. Demons, MD Kaycee M. Sink, MD, MAS Kimberly Kennedy, BA, CCRC Rachel Shertzer-Skinner, MA, CCRC Abbie Wrights, MS Rose Fries, RN, CCRC Deborah Barr, MA, RHEd, CHES Yale University, New Haven, CT Thomas M. Gill, MD, Field Center Principal Investigator Robert S. Axtell, PhD, FACSM, Field Center Co-Investigator (Exercise Science Department, Southern Connecticut State University, New Haven, CT) Susan S. Kashaf, MD, MPH (VA Connecticut Healthcare System, West Haven, CT) Nathalie de Rekeneire, MD, MS Joanne M. McGloin, MDiv, MS, MBA Karen C. Wu, RN Denise M. Shepard, RN, MBA Barbara Fennelly, MA, RN Lynne P. Iannone, MS, CCRP Raeleen Mautner, PhD Theresa Sweeney Barnett, MS, APRN Sean N. Halpin, MA Matthew J. Brennan, MA Julie A. Bugaj, MS Maria A. Zenoni, MS Bridget M. Mignosa, AS Cognition Coordinating Center, Wake Forest University, Winston Salem, NC Jeff Williamson, MD, MHS, Center Principal Investigator Kaycee M Sink, MD, MAS, Center Co-Investigator Hugh C. Hendrie, MB, ChB, DSc (Indiana University, Indianapolis, IN) Stephen R. Rapp, PhD Joe Verghese, MB, BS (Albert Einstein College of Medicine of Yeshiva University, New York, NY) Nancy Woolard Mark Espeland, PhD Janine Jennings, PhD Electrocardiogram Reading Center, University of Florida, Gainesville, FL Carl J. Pepine MD, MACC Mario Ariet, PhD Eileen Handberg, PhD, ARNP Daniel Deluca, BS James Hill, MD, MS, FACC Anita Szady, MD Spirometry Reading Center, Yale University, New Haven, CT Geoffrey L. Chupp, MD Gail M. Flynn, RCP, CRFT Thomas M. Gill, MD John L. Hankinson, PhD (Hankinson Consulting, Inc., Athens, GA) Carlos A. Vaz Fragoso, MD Cost-Effectiveness Analysis Center Erik J. Groessl, PhD (University of California, San Diego and VA San Diego Healthcare System, San Diego, CA) Robert M. Kaplan, PhD (Office of Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, MD)
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
AB - Objectives To evaluate the extent of variability in functional responses in participants in the Lifestyle Interventions and Independence for Elders (LIFE) study and to identify the relative contributions of intervention adherence, physical activity, and demographic and health characteristics to this variability. Design Secondary analysis. Setting Multicenter institutions. Participants A volunteer sample (N=1635) of sedentary men and women aged 70 to 89 years who were able to walk 400m but had physical limitations, defined as a Short Physical Performance Battery (SPPB) score of ≤9. Interventions Moderate-intensity physical activity (n=818) consisting of aerobic, resistance, and flexibility exercises performed both center-based (2times/wk) and home-based (3–4times/wk) sessions or health education program (n=817) consisting of weekly to monthly workshops covering relevant health information. Main Outcome Measures Physical function (gait speed over 400m) and lower extremity function (SPPB score) assessed at baseline and 6, 12, and 24 months. Results Greater baseline physical function (gait speed, SPPB score) was negatively associated with change in gait speed (regression coefficient β=−.185; P<.001) and change in SPPB score (β=−.365; P<.001), whereas higher number of steps per day measured by accelerometry was positively associated with change in gait speed (β=.035; P<.001) and change in SPPB score (β=.525; P<.001). Other baseline factors associated with positive change in gait speed and/or SPPB score include younger age (P<.001), lower body mass index (P<.001), and higher self-reported physical activity (P=.002). Conclusions Several demographic and physical activity–related factors were associated with the extent of change in functional outcomes in participants in the LIFE study. These factors should be considered when designing interventions for improving physical function in older adults with limited mobility.
KW - Aging
KW - Exercise
KW - Individuality
KW - Rehabilitation
KW - Resistance training
KW - Walking
UR - http://www.scopus.com/inward/record.url?scp=85005949399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85005949399&partnerID=8YFLogxK
U2 - 10.1016/j.apmr.2016.07.019
DO - 10.1016/j.apmr.2016.07.019
M3 - Article
C2 - 27568165
AN - SCOPUS:85005949399
VL - 98
SP - 11-24.e3
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
SN - 0003-9993
IS - 1
ER -