Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations

Chanita Hughes Halbert; Marc D. Schwartz; Lari Wenzel; Steven Narod; Beth N. Peshkin; David Cella; Caryn Lerman

doi:10.1023/B:JOBM.0000042411.56032.42

Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations

Chanita Hughes Halbert, Marc D. Schwartz, Lari Wenzel, Steven Narod, Beth N. Peshkin, David Cella, Caryn Lerman

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The objectives of this study were (1) to describe perceptions of stress and confidence following genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations and (2) to identify predictors of these processes. Participants were 130 high-risk women affected with cancer who received BRCA1/2 test results. Individual difference characteristics and interpersonal factors were measured by self-report before genetic counseling and perceptions of stress and confidence were evaluated by self-report 1 month following disclosure of test results. BRCA1/2 test results had a significant effect only on perceptions of stress (β = 0.38, p = 0.0001), while trait anxiety had a significant effect on both perceptions of stress (β = 0.44, p = 0.0001) and confidence (β = -0.41, p = 0.001). These results suggest that interventions designed to address perceptions of stress related to medical decision-making and familial concerns may need to be targeted to BRCA1/2 mutation carriers and individuals who are highly anxious.

Original language	English (US)
Pages (from-to)	373-392
Number of pages	20
Journal	Journal of Behavioral Medicine
Volume	27
Issue number	4
DOIs	https://doi.org/10.1023/B:JOBM.0000042411.56032.42
State	Published - Aug 2004

Keywords

BRCA1 and BRCA2
genetic testing
perceptions of stress and confidence

ASJC Scopus subject areas

Psychology(all)
Psychiatry and Mental health

Access to Document

10.1023/B:JOBM.0000042411.56032.42

Fingerprint Dive into the research topics of 'Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations'. Together they form a unique fingerprint.

Cite this

@article{ddb78b037a61474c919e8fafc64a6585,

title = "Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations",

abstract = "The objectives of this study were (1) to describe perceptions of stress and confidence following genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations and (2) to identify predictors of these processes. Participants were 130 high-risk women affected with cancer who received BRCA1/2 test results. Individual difference characteristics and interpersonal factors were measured by self-report before genetic counseling and perceptions of stress and confidence were evaluated by self-report 1 month following disclosure of test results. BRCA1/2 test results had a significant effect only on perceptions of stress (β = 0.38, p = 0.0001), while trait anxiety had a significant effect on both perceptions of stress (β = 0.44, p = 0.0001) and confidence (β = -0.41, p = 0.001). These results suggest that interventions designed to address perceptions of stress related to medical decision-making and familial concerns may need to be targeted to BRCA1/2 mutation carriers and individuals who are highly anxious.",

keywords = "BRCA1 and BRCA2, genetic testing, perceptions of stress and confidence",

author = "Halbert, {Chanita Hughes} and Schwartz, {Marc D.} and Lari Wenzel and Steven Narod and Peshkin, {Beth N.} and David Cella and Caryn Lerman",

note = "Funding Information: This research was supported by the National Human Genome Research Institute Grant No. HG01846. We thank study participants for their contribution to this research. We acknowledge Tiffani DeMarco, MS, Barbara Brogan, MS, RN, Elizabeth Hoodfar, MS, CGC, and Danielle Hanna, MS, CGC, for providing genetic counseling to study participants, Camille Corio, MS, for data management, and V. Holland LaSalle, BA, Susan Carey, BA, and Mary Kate Brousseau, BA, for conducting telephone interviews. We thank Scarlett Bellamy, PhD, for assistance with statistical analysis and Wilma Higginbotham for assistance with manuscript preparation.",

year = "2004",

month = aug,

doi = "10.1023/B:JOBM.0000042411.56032.42",

language = "English (US)",

volume = "27",

pages = "373--392",

journal = "Journal of Behavioral Medicine",

issn = "0160-7715",

publisher = "Springer New York",

number = "4",

}

TY - JOUR

T1 - Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations

AU - Halbert, Chanita Hughes

AU - Schwartz, Marc D.

AU - Wenzel, Lari

AU - Narod, Steven

AU - Peshkin, Beth N.

AU - Cella, David

AU - Lerman, Caryn

N1 - Funding Information: This research was supported by the National Human Genome Research Institute Grant No. HG01846. We thank study participants for their contribution to this research. We acknowledge Tiffani DeMarco, MS, Barbara Brogan, MS, RN, Elizabeth Hoodfar, MS, CGC, and Danielle Hanna, MS, CGC, for providing genetic counseling to study participants, Camille Corio, MS, for data management, and V. Holland LaSalle, BA, Susan Carey, BA, and Mary Kate Brousseau, BA, for conducting telephone interviews. We thank Scarlett Bellamy, PhD, for assistance with statistical analysis and Wilma Higginbotham for assistance with manuscript preparation.

PY - 2004/8

Y1 - 2004/8

N2 - The objectives of this study were (1) to describe perceptions of stress and confidence following genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations and (2) to identify predictors of these processes. Participants were 130 high-risk women affected with cancer who received BRCA1/2 test results. Individual difference characteristics and interpersonal factors were measured by self-report before genetic counseling and perceptions of stress and confidence were evaluated by self-report 1 month following disclosure of test results. BRCA1/2 test results had a significant effect only on perceptions of stress (β = 0.38, p = 0.0001), while trait anxiety had a significant effect on both perceptions of stress (β = 0.44, p = 0.0001) and confidence (β = -0.41, p = 0.001). These results suggest that interventions designed to address perceptions of stress related to medical decision-making and familial concerns may need to be targeted to BRCA1/2 mutation carriers and individuals who are highly anxious.

AB - The objectives of this study were (1) to describe perceptions of stress and confidence following genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations and (2) to identify predictors of these processes. Participants were 130 high-risk women affected with cancer who received BRCA1/2 test results. Individual difference characteristics and interpersonal factors were measured by self-report before genetic counseling and perceptions of stress and confidence were evaluated by self-report 1 month following disclosure of test results. BRCA1/2 test results had a significant effect only on perceptions of stress (β = 0.38, p = 0.0001), while trait anxiety had a significant effect on both perceptions of stress (β = 0.44, p = 0.0001) and confidence (β = -0.41, p = 0.001). These results suggest that interventions designed to address perceptions of stress related to medical decision-making and familial concerns may need to be targeted to BRCA1/2 mutation carriers and individuals who are highly anxious.

KW - BRCA1 and BRCA2

KW - genetic testing

KW - perceptions of stress and confidence

UR - http://www.scopus.com/inward/record.url?scp=4444314982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444314982&partnerID=8YFLogxK

U2 - 10.1023/B:JOBM.0000042411.56032.42

DO - 10.1023/B:JOBM.0000042411.56032.42

M3 - Article

C2 - 15559734

AN - SCOPUS:4444314982

VL - 27

SP - 373

EP - 392

JO - Journal of Behavioral Medicine

JF - Journal of Behavioral Medicine

SN - 0160-7715

IS - 4

ER -

Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this