Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations

Chanita Hughes Halbert, Marc D. Schwartz, Lari Wenzel, Steven Narod, Beth N. Peshkin, David Cella, Caryn Lerman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The objectives of this study were (1) to describe perceptions of stress and confidence following genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations and (2) to identify predictors of these processes. Participants were 130 high-risk women affected with cancer who received BRCA1/2 test results. Individual difference characteristics and interpersonal factors were measured by self-report before genetic counseling and perceptions of stress and confidence were evaluated by self-report 1 month following disclosure of test results. BRCA1/2 test results had a significant effect only on perceptions of stress (β = 0.38, p = 0.0001), while trait anxiety had a significant effect on both perceptions of stress (β = 0.44, p = 0.0001) and confidence (β = -0.41, p = 0.001). These results suggest that interventions designed to address perceptions of stress related to medical decision-making and familial concerns may need to be targeted to BRCA1/2 mutation carriers and individuals who are highly anxious.

Original languageEnglish (US)
Pages (from-to)373-392
Number of pages20
JournalJournal of Behavioral Medicine
Volume27
Issue number4
DOIs
StatePublished - Aug 1 2004

Keywords

  • BRCA1 and BRCA2
  • genetic testing
  • perceptions of stress and confidence

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health

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