Predictors of Pneumocystis carinii pneumonia in HIV-infected persons

John D. Stansell*, Dennis H. Osmond, Edwin Charlebois, Lisa Lavange, Jeanne M. Wallace, Barbara V. Alexander, Jeffrey Glassroth, Paul A. Kvale, Mark J. Rosen, Lee B. Reichman, Joan R. Turner, Philip C. Hopewell, Cynthia Merrifield, Melinda Mossar, Robert E Hirschtick, Lori Meiselman, Kim K. Manghisi, Christopher Cardozo, Thomas H. Kalb, Bonita T. ManguraSaundra Barnes, Bert Shapiro, Barbara LeMaire, Barbara Richer, Janet Au, Anne Coulson, Norman Markowitz, Louis D. Saravolatz, Christine Johnson, Joanne Huitsing, Ann Marie Krystoforski, W. Kenneth Poole, A. Vijaya Rao, Kim Clayton, Nellie I. Hansen, Matthew C. Jordan, Jim Thompson, David Myers, Judith Katzin, William Fulkerson, Tim Wilcosky, Anthony R. Kalica, Janet Wittes, Dean A. Follmann, Robert Wise

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV- infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There were 145 episodes of Pneumocystis carinii pneumonia (PCP). Low CD4 count correlated with risk of PCP (p < 0.0001); 79% had CD4 counts less than 100/μl and 95% had CD4 counts less than 200/μl. Subtle changes in diffusing capacity for carbon monoxide (DL(CO)) were associated with PCP. Univariate analysis identified recurrent undiagnosed fevers, night sweats, oropharyngeal thrush, and unintentional weight loss to be associated with risk among persons with CD4 counts above 200/μl. Subjects in whom CD4 counts declined to below 200/μl and who were not receiving preventive therapy were nine times more likely to develop PCP within 6 mo compared with subjects who received such therapy. A strong trend toward differences between the sexes was detected. Black subjects had less than one third the risk of developing PCP as did white subjects (p < 0.0001). There was no significant difference in risk by HIV transmission category, study site, frequency of follow-up, age, education, smoking history, or use of antiretroviral therapy. Multivariable analysis revealed low CD4 lymphocyte count (p < 0.0001), use of prophylaxis (p < 0.0001), racial differences (p < 0.0001), and declining DL(CO) (p = 0.015) to influence risk. Constitutional signs and symptoms indicate increased risk for PCP among HIV-infected persons with CD4 counts above 200/μl.

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalAmerican journal of respiratory and critical care medicine
Volume155
Issue number1
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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