Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation

Casey D. Xavier Hall, Michael E. Newcomb, Christina Dyar, Brian Mustanski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Daily oral preexposure prophylaxis (PrEP) for reducing HIV transmission is recommended for those at elevated risk, including sexual gender and minorities assigned male at birth (SGM-AMAB). Few studies have examined re-initiation among PrEP discontinuers, which is critical to ensuring optimization of PrEP’s protection. The current study examined predictors of re-initiation in a longitudinal sample of SGM-AMAB PrEP discontinuers (n = 253) from 10 waves of an ongoing cohort study (analytic n = 1,129). Multilevel structural equation models were used to examine the effects of psycho-social variables on re-initiation. In adjusted models, health insurance, and partner HIV positive status were significantly positively associated with PrEP re-initation. Being bisexual was significantly negatively associated with re-initiation relative to gay participants. Single status and open relationship agreements were associated with higher odds of re-initiation relative to monogamous relationships. Findings suggest that demographic, partnership characteristics and structural factors influence decisions to re-initiate PrEP after discontinuation.

Original languageEnglish (US)
Pages (from-to)2931-2940
Number of pages10
JournalAIDS and behavior
Volume26
Issue number9
DOIs
StatePublished - Sep 2022

Funding

This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar) and a grant from the National Institute on Minority Health and Health Disparities (R01MD013609; MPIs: Newcomb & Mustanski). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse. This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse.

Keywords

  • HIV
  • PrEP
  • Pre-exposure prophylaxis
  • Re-initiation

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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