Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation

Casey D. Xavier Hall, Michael E. Newcomb, Christina Dyar, Brian Mustanski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Daily oral preexposure prophylaxis (PrEP) for reducing HIV transmission is recommended for those at elevated risk, including sexual gender and minorities assigned male at birth (SGM-AMAB). Few studies have examined re-initiation among PrEP discontinuers, which is critical to ensuring optimization of PrEP’s protection. The current study examined predictors of re-initiation in a longitudinal sample of SGM-AMAB PrEP discontinuers (n = 253) from 10 waves of an ongoing cohort study (analytic n = 1,129). Multilevel structural equation models were used to examine the effects of psycho-social variables on re-initiation. In adjusted models, health insurance, and partner HIV positive status were significantly positively associated with PrEP re-initation. Being bisexual was significantly negatively associated with re-initiation relative to gay participants. Single status and open relationship agreements were associated with higher odds of re-initiation relative to monogamous relationships. Findings suggest that demographic, partnership characteristics and structural factors influence decisions to re-initiate PrEP after discontinuation.

Original languageEnglish (US)
Pages (from-to)2931-2940
Number of pages10
JournalAIDS and behavior
Issue number9
StatePublished - Sep 2022


  • HIV
  • PrEP
  • Pre-exposure prophylaxis
  • Re-initiation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology


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