Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation

Casey D. Xavier Hall; Michael E. Newcomb; Christina Dyar; Brian Mustanski

doi:10.1007/s10461-022-03625-5

Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation

Casey D. Xavier Hall, Michael E. Newcomb, Christina Dyar, Brian Mustanski^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Daily oral preexposure prophylaxis (PrEP) for reducing HIV transmission is recommended for those at elevated risk, including sexual gender and minorities assigned male at birth (SGM-AMAB). Few studies have examined re-initiation among PrEP discontinuers, which is critical to ensuring optimization of PrEP’s protection. The current study examined predictors of re-initiation in a longitudinal sample of SGM-AMAB PrEP discontinuers (n = 253) from 10 waves of an ongoing cohort study (analytic n = 1,129). Multilevel structural equation models were used to examine the effects of psycho-social variables on re-initiation. In adjusted models, health insurance, and partner HIV positive status were significantly positively associated with PrEP re-initation. Being bisexual was significantly negatively associated with re-initiation relative to gay participants. Single status and open relationship agreements were associated with higher odds of re-initiation relative to monogamous relationships. Findings suggest that demographic, partnership characteristics and structural factors influence decisions to re-initiate PrEP after discontinuation.

Original language	English (US)
Pages (from-to)	2931-2940
Number of pages	10
Journal	AIDS and behavior
Volume	26
Issue number	9
DOIs	https://doi.org/10.1007/s10461-022-03625-5
State	Published - Sep 2022

Funding

This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar) and a grant from the National Institute on Minority Health and Health Disparities (R01MD013609; MPIs: Newcomb & Mustanski). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse. This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse.

Keywords

HIV
PrEP
Pre-exposure prophylaxis
Re-initiation

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10461-022-03625-5

Cite this

@article{bf0022fcc6a84e47936a3a2a8bda42b6,

title = "Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation",

abstract = "Daily oral preexposure prophylaxis (PrEP) for reducing HIV transmission is recommended for those at elevated risk, including sexual gender and minorities assigned male at birth (SGM-AMAB). Few studies have examined re-initiation among PrEP discontinuers, which is critical to ensuring optimization of PrEP{\textquoteright}s protection. The current study examined predictors of re-initiation in a longitudinal sample of SGM-AMAB PrEP discontinuers (n = 253) from 10 waves of an ongoing cohort study (analytic n = 1,129). Multilevel structural equation models were used to examine the effects of psycho-social variables on re-initiation. In adjusted models, health insurance, and partner HIV positive status were significantly positively associated with PrEP re-initation. Being bisexual was significantly negatively associated with re-initiation relative to gay participants. Single status and open relationship agreements were associated with higher odds of re-initiation relative to monogamous relationships. Findings suggest that demographic, partnership characteristics and structural factors influence decisions to re-initiate PrEP after discontinuation.",

keywords = "HIV, PrEP, Pre-exposure prophylaxis, Re-initiation",

author = "{Xavier Hall}, {Casey D.} and Newcomb, {Michael E.} and Christina Dyar and Brian Mustanski",

note = "Funding Information: This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar) and a grant from the National Institute on Minority Health and Health Disparities (R01MD013609; MPIs: Newcomb & Mustanski). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse. Funding Information: This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = sep,

doi = "10.1007/s10461-022-03625-5",

language = "English (US)",

volume = "26",

pages = "2931--2940",

journal = "AIDS and behavior",

issn = "1090-7165",

publisher = "Springer New York",

number = "9",

}

TY - JOUR

T1 - Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation

AU - Xavier Hall, Casey D.

AU - Newcomb, Michael E.

AU - Dyar, Christina

AU - Mustanski, Brian

N1 - Funding Information: This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar) and a grant from the National Institute on Minority Health and Health Disparities (R01MD013609; MPIs: Newcomb & Mustanski). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse. Funding Information: This study was supported by a grants from the National Institute on Drug Abuse (U01DA036939; PI: Mustanski) and (K01DA046716, PI: Dyar). The content of this article is solely the responsibility of the authors and does not necessarily reflect the views of the National Institutes of Health or the National Institute on Drug Abuse. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2022/9

Y1 - 2022/9

N2 - Daily oral preexposure prophylaxis (PrEP) for reducing HIV transmission is recommended for those at elevated risk, including sexual gender and minorities assigned male at birth (SGM-AMAB). Few studies have examined re-initiation among PrEP discontinuers, which is critical to ensuring optimization of PrEP’s protection. The current study examined predictors of re-initiation in a longitudinal sample of SGM-AMAB PrEP discontinuers (n = 253) from 10 waves of an ongoing cohort study (analytic n = 1,129). Multilevel structural equation models were used to examine the effects of psycho-social variables on re-initiation. In adjusted models, health insurance, and partner HIV positive status were significantly positively associated with PrEP re-initation. Being bisexual was significantly negatively associated with re-initiation relative to gay participants. Single status and open relationship agreements were associated with higher odds of re-initiation relative to monogamous relationships. Findings suggest that demographic, partnership characteristics and structural factors influence decisions to re-initiate PrEP after discontinuation.

AB - Daily oral preexposure prophylaxis (PrEP) for reducing HIV transmission is recommended for those at elevated risk, including sexual gender and minorities assigned male at birth (SGM-AMAB). Few studies have examined re-initiation among PrEP discontinuers, which is critical to ensuring optimization of PrEP’s protection. The current study examined predictors of re-initiation in a longitudinal sample of SGM-AMAB PrEP discontinuers (n = 253) from 10 waves of an ongoing cohort study (analytic n = 1,129). Multilevel structural equation models were used to examine the effects of psycho-social variables on re-initiation. In adjusted models, health insurance, and partner HIV positive status were significantly positively associated with PrEP re-initation. Being bisexual was significantly negatively associated with re-initiation relative to gay participants. Single status and open relationship agreements were associated with higher odds of re-initiation relative to monogamous relationships. Findings suggest that demographic, partnership characteristics and structural factors influence decisions to re-initiate PrEP after discontinuation.

KW - HIV

KW - PrEP

KW - Pre-exposure prophylaxis

KW - Re-initiation

UR - http://www.scopus.com/inward/record.url?scp=85126062956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85126062956&partnerID=8YFLogxK

U2 - 10.1007/s10461-022-03625-5

DO - 10.1007/s10461-022-03625-5

M3 - Article

C2 - 35267107

AN - SCOPUS:85126062956

SN - 1090-7165

VL - 26

SP - 2931

EP - 2940

JO - AIDS and behavior

JF - AIDS and behavior

IS - 9

ER -

Predictors of Re-Initiation of Daily Oral Preexposure Prophylaxis Regimen After Discontinuation

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this