Predictors of urinary phthalate biomarker concentrations in postmenopausal women

Katherine W. Reeves, Mary Díaz Santana, Jo Ann E. Manson, Susan E. Hankinson, R. Thomas Zoeller, Carol Bigelow, Lifang Hou, Jean Wactawski-Wende, Simin Liu, Lesley Tinker, Antonia M. Calafat

Research output: Contribution to journalArticle

Abstract

Background: Phthalates are ubiquitous endocrine disrupting chemicals present in a wide variety of consumer products. However, the personal characteristics associated with phthalate exposure are unclear. Objectives: We sought to describe personal, behavioral, and reproductive characteristics associated with phthalate metabolite concentrations in an ongoing study nested within the Women's Health Initiative (WHI). Materials and Methods: We measured thirteen phthalate metabolites in two or three archived urine samples collected in 1993–2001 from each of 1257 WHI participants (2991 observations). We fit multivariable generalized estimating equation models to predict urinary biomarker concentrations from personal, behavioral, and reproductive characteristics. Results: Older age was predictive of lower concentrations of monobenzyl phthalate (MBzP), mono-carboxyoctyl phthalate (MCOP), mono-3-carboxypropyl phthalate (MCPP), and the sum of di-n-butyl phthalate metabolites (ΣDBP). Phthalate metabolite concentrations varied by race/region, with generally higher concentrations observed among non-Whites and women from the West region. Higher neighborhood socioeconomic status predicted lower MBzP concentrations, and higher education predicted lower monoethyl phthalate (MEP) and higher concentrations of the sum of metabolites of di-isobutyl phthalate (ΣDiBP). Overweight/obesity predicted higher MBzP, MCOP, monocarboxynonyl phthalate (MCNP), MCPP, and the sum of metabolites of di(2-ethylhexyl) phthalate (ΣDEHP) and lower MEP concentrations. Alcohol consumption predicted higher concentrations of MEP and ΣDBP, while current smokers had higher ΣDBP concentrations. Better diet quality as assessed by Healthy Eating Index 2005 scores predicted lower concentrations of MBzP, ΣDiBP, and ΣDEHP. Conclusion: Factors predictive of lower biomarker concentrations included increased age and healthy behaviors (e.g. lower alcohol intake, lower body mass index, not smoking, higher quality diet, and moderate physical activity). Racial group (generally higher among non-Whites) and geographic regions (generally higher in Northeast and West compared to South regions) also were predictive of phthalate biomarker concentrations.

LanguageEnglish (US)
Pages122-130
Number of pages9
JournalEnvironmental Research
Volume169
DOIs
StatePublished - Feb 1 2019

Fingerprint

phthalate
Biomarkers
biomarker
Metabolites
metabolite
woman
phthalic acid
Women's Health
Nutrition
womens health
Alcohols
Dibutyl Phthalate
Diet
alcohol
Endocrine Disruptors
Consumer products
diet
Social Class
Alcohol Drinking
physical activity

Keywords

  • Phthalates
  • Postmenopausal
  • Women

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Reeves, K. W., Santana, M. D., Manson, J. A. E., Hankinson, S. E., Zoeller, R. T., Bigelow, C., ... Calafat, A. M. (2019). Predictors of urinary phthalate biomarker concentrations in postmenopausal women. Environmental Research, 169, 122-130. https://doi.org/10.1016/j.envres.2018.10.024
Reeves, Katherine W. ; Santana, Mary Díaz ; Manson, Jo Ann E. ; Hankinson, Susan E. ; Zoeller, R. Thomas ; Bigelow, Carol ; Hou, Lifang ; Wactawski-Wende, Jean ; Liu, Simin ; Tinker, Lesley ; Calafat, Antonia M. / Predictors of urinary phthalate biomarker concentrations in postmenopausal women. In: Environmental Research. 2019 ; Vol. 169. pp. 122-130.
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Reeves, KW, Santana, MD, Manson, JAE, Hankinson, SE, Zoeller, RT, Bigelow, C, Hou, L, Wactawski-Wende, J, Liu, S, Tinker, L & Calafat, AM 2019, 'Predictors of urinary phthalate biomarker concentrations in postmenopausal women' Environmental Research, vol. 169, pp. 122-130. https://doi.org/10.1016/j.envres.2018.10.024

Predictors of urinary phthalate biomarker concentrations in postmenopausal women. / Reeves, Katherine W.; Santana, Mary Díaz; Manson, Jo Ann E.; Hankinson, Susan E.; Zoeller, R. Thomas; Bigelow, Carol; Hou, Lifang; Wactawski-Wende, Jean; Liu, Simin; Tinker, Lesley; Calafat, Antonia M.

In: Environmental Research, Vol. 169, 01.02.2019, p. 122-130.

Research output: Contribution to journalArticle

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AU - Santana, Mary Díaz

AU - Manson, Jo Ann E.

AU - Hankinson, Susan E.

AU - Zoeller, R. Thomas

AU - Bigelow, Carol

AU - Hou, Lifang

AU - Wactawski-Wende, Jean

AU - Liu, Simin

AU - Tinker, Lesley

AU - Calafat, Antonia M.

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Reeves KW, Santana MD, Manson JAE, Hankinson SE, Zoeller RT, Bigelow C et al. Predictors of urinary phthalate biomarker concentrations in postmenopausal women. Environmental Research. 2019 Feb 1;169:122-130. https://doi.org/10.1016/j.envres.2018.10.024