TY - JOUR
T1 - Predisposing factors and prognosis of status epilepticus in patients with autoimmune encephalitis
AU - Zhang, Yu
AU - Deng, Chen
AU - Zhu, Lina
AU - Ling, Liu
AU - Lukas, Rimas Vincas
N1 - Funding Information:
This study was funded by the Science & Technology Department of Sichuan Province [grant number 2018SZ0166].
Publisher Copyright:
Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2020/3/11
Y1 - 2020/3/11
N2 - The aim of this study was to study the predisposing factors and prognosis of status epilepticus (SE) in patients with autoimmune encephalitis (AE).A total of 227 cases of AE were collected from the inpatient department of West China Hospital of Sichuan University from January 2010 to May 2018. All patients met the 2015 criteria for the diagnosis of AE. The binary logistic regression model was used to multivariate and retrospective chart analysis the predisposition factors for SE and its prognostic factors.Of the 227 patients with AE, 50 (22.03%) had SE during hospitalization, and 19 patients with SE had a poor prognosis (modified Rankin score MRS = 3-6), and 7 patients with no SE had a poor prognosis. In the logistic regression model, electroencephalograms (EEGs) abnormalities (P = .000) and head magnetic resonance imaging (MRI) abnormalities (P = .003) were associated with a predisposition to SE, while Glasgow scores <8 (P = .027), abnormal EEG (P = .046), delayed immunotherapy (P = .012), and SE duration at admission lasting >30 minutes (P = .023) were risk factors for a poor prognosis of SE.SE is a common complication in patients with AE. EEG and MRI abnormalities may be predisposing factors for SE. Glasgow scores <8 points, abnormal EEG, delayed immunotherapy, and SE duration lasting >30 minutes at admission are risk factors for a poor prognosis in patients with SE.
AB - The aim of this study was to study the predisposing factors and prognosis of status epilepticus (SE) in patients with autoimmune encephalitis (AE).A total of 227 cases of AE were collected from the inpatient department of West China Hospital of Sichuan University from January 2010 to May 2018. All patients met the 2015 criteria for the diagnosis of AE. The binary logistic regression model was used to multivariate and retrospective chart analysis the predisposition factors for SE and its prognostic factors.Of the 227 patients with AE, 50 (22.03%) had SE during hospitalization, and 19 patients with SE had a poor prognosis (modified Rankin score MRS = 3-6), and 7 patients with no SE had a poor prognosis. In the logistic regression model, electroencephalograms (EEGs) abnormalities (P = .000) and head magnetic resonance imaging (MRI) abnormalities (P = .003) were associated with a predisposition to SE, while Glasgow scores <8 (P = .027), abnormal EEG (P = .046), delayed immunotherapy (P = .012), and SE duration at admission lasting >30 minutes (P = .023) were risk factors for a poor prognosis of SE.SE is a common complication in patients with AE. EEG and MRI abnormalities may be predisposing factors for SE. Glasgow scores <8 points, abnormal EEG, delayed immunotherapy, and SE duration lasting >30 minutes at admission are risk factors for a poor prognosis in patients with SE.
KW - autoimmune encephalitis
KW - prognosis
KW - status epilepticus
UR - http://www.scopus.com/inward/record.url?scp=85082510140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85082510140&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000019601
DO - 10.1097/MD.0000000000019601
M3 - Article
C2 - 32221081
AN - SCOPUS:85082510140
SN - 0025-7974
VL - 99
SP - E19601
JO - Medicine (United States)
JF - Medicine (United States)
IS - 13
ER -