Preexisting melanoma and hematological malignancies, prognosis, and timing to solid organ transplantation: A consensus expert opinion statement

David P. Al-Adra, Laura Hammel, John Roberts, E. Steve Woodle, Deborah Levine, Didier Mandelbrot, Elizabeth Verna, Jayme Locke, Jonathan D'Cunha, Maryjane Farr, Deirdre Sawinski, Piyush K. Agarwal, Jennifer Plichta, Sandhya Pruthi, Deborah Farr, Richard Carvajal, John Walker, Fiona Zwald, Thomas Habermann, Morie GertzPhilip Bierman, Don S. Dizon, Carrie Langstraat, Talal Al-Qaoud, Scott Eggener, John P. Richgels, George J. Chang, Cristina Geltzeiler, Gonzalo Sapisochin, Rocco Ricciardi, Alexander S. Krupnick, Cassie Kennedy, Nisha Mohindra, David P. Foley, Kymberly D. Watt*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Patients undergoing evaluation for solid organ transplantation (SOT) frequently have a history of malignancy. Only patients with treated cancer are considered for SOT but the benefits of transplantation need to be balanced against the risk of tumor recurrence, taking into consideration the potential effects of immunosuppression. Prior guidelines on timing to transplant in patients with a prior treated malignancy do not account for current staging, disease biology, or advances in cancer treatments. To update these recommendations, the American Society of Transplantation (AST) facilitated a consensus workshop to comprehensively review contemporary literature regarding cancer therapies, cancer stage specific prognosis, the kinetics of cancer recurrence, as well as the limited data on the effects of immunosuppression on cancer-specific outcomes. This document contains prognosis, treatment, and transplant recommendations for melanoma and hematological malignancies. Given the limited data regarding the risk of cancer recurrence in transplant recipients, the goal of the AST-sponsored conference and the consensus documents produced are to provide expert opinion recommendations that help in the evaluation of patients with a history of a pretransplant malignancy for transplant candidacy.

Original languageEnglish (US)
JournalAmerican Journal of Transplantation
DOIs
StateAccepted/In press - 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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