| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-166 |
| Number of pages | 2 |
| Journal | Best Practice and Research: Clinical Rheumatology |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
Funding
The role of sex hormones in SLE has been studied extensively in an animal model for SLE, the NZB/NZW F1 mouse. In this model, renal disease and autoantibody production progress more rapidly in females. Androgen and castration decrease disease activity in females, whereas castration or oestrogen therapy increases activity in males. Indeed, sex hormones have a profound effect on the immune system. The safety of female sex hormones in everyday practice across a woman's life cycle is reviewed in this issue. Decision-making with regard to the use of sex hormones will be sharpened when a trial, funded by the National Institutes of Health (SELENA), is completed.
ASJC Scopus subject areas
- Rheumatology