Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men

George J. Greene, Greg Swann, Angela J. Fought, Alex Carballo-Diéguez, Thomas J. Hope, Patrick F. Kiser, Brian Mustanski, Richard T. D’Aquila*

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Scopus citations


HIV prevention method preferences were evaluated among 512 U.S. men who have sex with men (MSM; median age: 22 years). Approximately 90 % consistently preferred one option across pairwise comparisons of condoms, daily oral pre-exposure prophylaxis (PrEP), and long-acting PrEP delivered via either an injectable or one of two types of PrEP implants differing in visibility. Condoms were most frequently preferred (33.8 %), followed by non-visible implants (21.5 %), and oral PrEP (17.0 %); HIV risk was reported by more choosing implants. In a follow-up question comparing the four PrEP options only, daily oral pills and non-visible implants were most frequently preferred (35.5 and 34.3 %, respectively), followed by injections (25.2 %) and visible implants (4.3 %). An inductive, open-coding approach determined that convenience, duration of protection, and privacy were the most commonly cited reasons for a PrEP method choice, and associated with self-report of HIV risk. Tailoring PrEP product development to privacy and other concerns important to those at highest HIV risk may improve HIV prevention.

Original languageEnglish (US)
Pages (from-to)1336-1349
Number of pages14
JournalAIDS and behavior
Issue number5
StatePublished - May 1 2017



  • HIV
  • Homosexuality
  • Male
  • Pre-exposure prophylaxis
  • Prevention
  • Sexual behavior

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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