Pregabalin in patients with primary brain tumors and seizures: A preliminary observation

Jan Novy, Roger Stupp, Andrea O. Rossetti*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Objectives: Patients with brain tumors and seizures should be treated with non-enzyme-inducing antiepileptic drugs (AED). Some of the newer drugs seem particularly suited in these patients. Methods: Here we describe our experience with pregabalin (PGB); its effectiveness was retrospectively studied in nine consecutive patients with primary brain tumors and seizures. Results: Six subjects had secondarily generalized and three simple partial seizures. Patients mostly suffered from WHO grade IV gliomas. PGB replaced enzyme inducing, inefficacious or bad tolerated AED, as add-on or monotherapy. Median follow-up was 5 (2-19) months; three patients died of their tumor. Daily median dosage was 300 mg. All subjects experienced at least a 50% seizure reduction, six were seizure-free. Side effects were reported in four patients, leading to PGB discontinuation in two. Conclusion: PGB appears to have a promising effectiveness in this setting, even as a monotherapy. Based on these results we embarked on a prospective controlled trial.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalClinical Neurology and Neurosurgery
Volume111
Issue number2
DOIs
StatePublished - Feb 1 2009

Keywords

  • Chemotherapy
  • Epilepsy
  • Interactions
  • Pregabalin
  • Primary brain tumors

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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