Pregnancy and the Hyperprolactinemic Woman

Mark E. Molitch*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

202 Scopus citations


HYPERPROLACTINEMIA has been found to be the cause of infertility in about one third of women presenting with this problem.1 2 3 Hyperprolactinemia may impair the hypothalamic–pituitary–ovarian axis at several levels, with the primary site of inhibition probably at the hypothalamic level.4,5 Studies of gonadotropin secretion in hyperprolactinemic subjects sometimes show decreased pulsatile secretion,6,7 which reverts to normal in most women when hyperprolactinemia is corrected by bromocriptine treatment.6,7 Pituitary responsiveness to gonadotropin-releasing hormone is normal in such women, however, and a normal pattern of gonadotropin pulsatile secretion is restored with small, repetitive doses of the hormone.7 Such data support the concept that.

Original languageEnglish (US)
Pages (from-to)1364-1370
Number of pages7
JournalNew England Journal of Medicine
Issue number21
StatePublished - May 23 1985

ASJC Scopus subject areas

  • Medicine(all)


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