The presence of abnormal B-lymphocyte function, resulting in the production of abnormal autoantibodies has been established as a probable contributing factor to approximately 5 to 15 per cent of pregnancy loss. Because this association has so far not been established as causative within an experimental framework, caution should be exercised before such an etiologic assumption is made in a specific clinical situation. Nonimmunologic and nonautoimmune immunologic causes for pregnancy loss should be ruled out before an autoimmune pathophysiology is assumed and directed treatment is initiated. Because no single autoantibody abnormality is specific for pregnancy loss, at present a broadly based investigation of B-lymphocyte function appears indicated in patients with recurrent pregnancy wastage. It is hoped that ongoing research will lead to more specific markers of autoantibody-induced reproductive failure.
|Original language||English (US)|
|Journal||Immunology and Allergy Clinics of North America|
|State||Published - Jan 1 1990|
ASJC Scopus subject areas
- Immunology and Allergy