Preimplantation genetic testing: Indications and controversies

Amber R. Cooper; Emily S. Jungheim

doi:10.1016/j.cll.2010.04.008

Preimplantation genetic testing: Indications and controversies

Amber R. Cooper^*, Emily S. Jungheim

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

In the last two decades, the use of preimplantation genetic testing has increased dramatically. This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. Genetic testing strategies and diagnostic accuracy continues to improve, but not without risks or controversies. In this review the authors discuss the techniques and clinical application of preimplantation genetic diagnosis, and the debate surrounding its associated uncertainty and expanded use.

Original language	English (US)
Pages (from-to)	519-531
Number of pages	13
Journal	Clinics in Laboratory Medicine
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.cll.2010.04.008
State	Published - Sep 2010
Externally published	Yes

Keywords

Embryo biopsy
Embryo research
In vitro fertilization
Preimplantation genetic diagnosis
Preimplantation genetic screening
Preimplantation genetic testing

ASJC Scopus subject areas

Clinical Biochemistry
Biochemistry, medical

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10.1016/j.cll.2010.04.008

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title = "Preimplantation genetic testing: Indications and controversies",

abstract = "In the last two decades, the use of preimplantation genetic testing has increased dramatically. This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. Genetic testing strategies and diagnostic accuracy continues to improve, but not without risks or controversies. In this review the authors discuss the techniques and clinical application of preimplantation genetic diagnosis, and the debate surrounding its associated uncertainty and expanded use.",

keywords = "Embryo biopsy, Embryo research, In vitro fertilization, Preimplantation genetic diagnosis, Preimplantation genetic screening, Preimplantation genetic testing",

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AU - Jungheim, Emily S.

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AB - In the last two decades, the use of preimplantation genetic testing has increased dramatically. This testing is used for identifying singlegene disorders, chromosomal abnormalities, mitochondrial disorders, gender selection in non-mendelian disorders with unequal gender distribution, aneuploidy screening, and other preconceptually identified genetic abnormalities in prospective parents. Genetic testing strategies and diagnostic accuracy continues to improve, but not without risks or controversies. In this review the authors discuss the techniques and clinical application of preimplantation genetic diagnosis, and the debate surrounding its associated uncertainty and expanded use.

KW - Embryo biopsy

KW - Embryo research

KW - In vitro fertilization

KW - Preimplantation genetic diagnosis

KW - Preimplantation genetic screening

KW - Preimplantation genetic testing

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Preimplantation genetic testing: Indications and controversies

Abstract

Keywords

ASJC Scopus subject areas

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