Preliminary studies and potential applications of localized surface plasmon resonance spectroscopy in medical diagnostics

Amanda J. Haes, Richard P. Van Duyne*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

164 Scopus citations

Abstract

Miniature optical sensors that specifically identify low concentrations of environmental and biological substances are in high demand. Currently, there is no optical sensor that provides identification of the aforementioned species without amplification techniques at naturally occurring concentrations. Recently, it has been demonstrated that triangular silver nanoparticles have remarkable optical properties and that their enhanced sensitivity to their nanoenvironment has been used to develop a new class of optical sensors using localized surface plasmon resonance spectroscopy. The examination of both model and nonmodel biological assays using localized surface plasmon resonance spectroscopy will be presented in this review. It will be demonstrated that the use of a localized surface plasmon resonance nanosensors rivals the sensitivity and selectivity of, and provides a low-cost alternative to, commercially available sensors.

Original languageEnglish (US)
Pages (from-to)527-537
Number of pages11
JournalExpert Review of Molecular Diagnostics
Volume4
Issue number4
DOIs
StatePublished - Jul 2004

Keywords

  • Biosensing
  • Disease diagnosis
  • Localized surface plasmon resonance nanosensor
  • Single nanoparticle spectroscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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