Premature and early menopause among US women with or at risk for HIV

Brooke W. Bullington; Andrew Edmonds; Catalina Ramirez; Lisa Rahangdale; Genevieve Neal-Perry; Deborah Konkle-Parker; Deborah Jones Weiss; Caitlin Moran; Elizabeth Topper Golub; Helen Cejtin; Dominika Seidman; Seble Kassaye; Tracey E. Wilson; Anjali Sharma; Adaora A. Adimora; Andrea K. Knittel

doi:10.1097/GME.0000000000001964

Premature and early menopause among US women with or at risk for HIV

Brooke W. Bullington^*, Andrew Edmonds, Catalina Ramirez, Lisa Rahangdale, Genevieve Neal-Perry, Deborah Konkle-Parker, Deborah Jones Weiss, Caitlin Moran, Elizabeth Topper Golub, Helen Cejtin, Dominika Seidman, Seble Kassaye, Tracey E. Wilson, Anjali Sharma, Adaora A. Adimora, Andrea K. Knittel

^*Corresponding author for this work

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective:Little is known about the prevalence and treatment of premature and early menopause among people with HIV. We described premature and early menopause and subsequent hormonal treatment in a longitudinal cohort of women living with or at risk for HIV in the US.Methods:Data from the Women's Interagency HIV Study between 2008 and 2020 were analyzed to describe premature and early menopause among cohort participants under the age of 51.Results:Of 3,059 eligible women during the study period, 1% (n=35) underwent premature menopause before age 41, 3% (n=101) underwent menopause between ages 41 and 46, and 21% (n=442) underwent menopause between ages 46 and 50, inclusive. Of participants who experienced menopause before age 41, between age 41 and 45, and between ages 46 and 50, 51%, 24%, and 7% (respectively) received either menopausal hormone therapy or hormonal contraception.Conclusion:These findings suggest that disparities in receipt of recommended hormone therapy for premature and early menopause may contribute, in part, to evident health disparities, such as cardiovascular disease, osteoporosis, and overall mortality. They also suggest a substantial need for education among people experiencing early menopause and their providers, with the goal of improving access to hormone therapy based on guidelines to address health disparities and minimize future health consequences.

Original language	English (US)
Pages (from-to)	741-747
Number of pages	7
Journal	Menopause
Volume	29
Issue number	6
DOIs	https://doi.org/10.1097/GME.0000000000001964
State	Published - Jun 14 2022

Funding

Data in this manuscript were collected by the Women's Interagency HIV Study (WIHS), now part of the MACS/WIHS Combined Cohort Study (MWCCS). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health. MWCCS (Principal Investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01- HL146241; Bronx CrS (Kathryn Anastos and Anjali Sharma), U01- HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; Data Analysis and Coordination Center (Gypsyamber D'Souza, Stephen Gange and Elizabeth Golub), U01-Hl146193; Chicago-Cook County CRS (Mardge Cohen and Audrey French), U01- HL146245; Northern California CRS (Bradley Aouizerat, Jennifer Price, and Phyllis Tien), U01-HL146242; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; UAB- MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; UNC CRS (Adaora Adimora), U01- HL146194. The MWCCS is funded primarily by the National Heart, Lung, and Blood Institute (NHLBI), with additional co-funding from the Eunice Kennedy Shriver National Institute Of Child Health & Human Development (NICHD), National Institute On Aging (NIA), National Institute Of Dental & Craniofacial Research (NIDCR), National Institute Of Allergy And Infectious Diseases (NIAID), National Institute Of Neurological Disorders And Stroke (NINDS), National Institute Of Mental Health (NIMH), National Institute On Drug Abuse (NIDA), National Institute Of Nursing Research (NINR), National Cancer Institute (NCI), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute on Minority Health and Health Disparities (NIMHD), and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research (OAR). MWCCS data collection is also supported by UL1- TR000004 (UCSF CTSA), P30-AI-050409 (Atlanta CFAR), P30-AI- 073961 (Miami CFAR), P30-AI-050410 (UNC CFAR), P30-AI- 027767 (UAB CFAR), and P30-MH-116867 (Miami CHARM). Funding/support: This project was supported by funds from the University of North Carolina at Chapel Hill School of Medicine (Knittel, Bullington), the National Institute of Child Health and Human Development (NICHD) (Knittel, K12HD103085, PI Neal-Perry; Bullington, T32HD52468, and PI Julie Daniels), an infrastructure grant for population research (Bullington, P2CHD050924, PI Elizabeth Frankenberg) to the Carolina Population Center at the University of North Carolina at Chapel Hill and the UNC site of MACS/WIHS Combined Cohort Study (MWCCS) which is primarily funded by the National Heart, Lung, and Blood Institute (NHLBI) (Bullington,U01-HL146194, PI Adimora).

Keywords

Early menopause
HIV
Menopausal hormone therapy
Premature menopause

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/GME.0000000000001964

Cite this

Bullington, B. W., Edmonds, A., Ramirez, C., Rahangdale, L., Neal-Perry, G., Konkle-Parker, D., Weiss, D. J., Moran, C., Golub, E. T., Cejtin, H., Seidman, D., Kassaye, S., Wilson, T. E., Sharma, A., Adimora, A. A., & Knittel, A. K. (2022). Premature and early menopause among US women with or at risk for HIV. Menopause, 29(6), 741-747. https://doi.org/10.1097/GME.0000000000001964

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title = "Premature and early menopause among US women with or at risk for HIV",

abstract = "Objective:Little is known about the prevalence and treatment of premature and early menopause among people with HIV. We described premature and early menopause and subsequent hormonal treatment in a longitudinal cohort of women living with or at risk for HIV in the US.Methods:Data from the Women's Interagency HIV Study between 2008 and 2020 were analyzed to describe premature and early menopause among cohort participants under the age of 51.Results:Of 3,059 eligible women during the study period, 1% (n=35) underwent premature menopause before age 41, 3% (n=101) underwent menopause between ages 41 and 46, and 21% (n=442) underwent menopause between ages 46 and 50, inclusive. Of participants who experienced menopause before age 41, between age 41 and 45, and between ages 46 and 50, 51%, 24%, and 7% (respectively) received either menopausal hormone therapy or hormonal contraception.Conclusion:These findings suggest that disparities in receipt of recommended hormone therapy for premature and early menopause may contribute, in part, to evident health disparities, such as cardiovascular disease, osteoporosis, and overall mortality. They also suggest a substantial need for education among people experiencing early menopause and their providers, with the goal of improving access to hormone therapy based on guidelines to address health disparities and minimize future health consequences.",

keywords = "Early menopause, HIV, Menopausal hormone therapy, Premature menopause",

author = "Bullington, {Brooke W.} and Andrew Edmonds and Catalina Ramirez and Lisa Rahangdale and Genevieve Neal-Perry and Deborah Konkle-Parker and Weiss, {Deborah Jones} and Caitlin Moran and Golub, {Elizabeth Topper} and Helen Cejtin and Dominika Seidman and Seble Kassaye and Wilson, {Tracey E.} and Anjali Sharma and Adimora, {Adaora A.} and Knittel, {Andrea K.}",

year = "2022",

month = jun,

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doi = "10.1097/GME.0000000000001964",

language = "English (US)",

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pages = "741--747",

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AU - Bullington, Brooke W.

AU - Edmonds, Andrew

AU - Ramirez, Catalina

AU - Rahangdale, Lisa

AU - Neal-Perry, Genevieve

AU - Konkle-Parker, Deborah

AU - Weiss, Deborah Jones

AU - Moran, Caitlin

AU - Golub, Elizabeth Topper

AU - Cejtin, Helen

AU - Seidman, Dominika

AU - Kassaye, Seble

AU - Wilson, Tracey E.

AU - Sharma, Anjali

AU - Adimora, Adaora A.

AU - Knittel, Andrea K.

PY - 2022/6/14

Y1 - 2022/6/14

N2 - Objective:Little is known about the prevalence and treatment of premature and early menopause among people with HIV. We described premature and early menopause and subsequent hormonal treatment in a longitudinal cohort of women living with or at risk for HIV in the US.Methods:Data from the Women's Interagency HIV Study between 2008 and 2020 were analyzed to describe premature and early menopause among cohort participants under the age of 51.Results:Of 3,059 eligible women during the study period, 1% (n=35) underwent premature menopause before age 41, 3% (n=101) underwent menopause between ages 41 and 46, and 21% (n=442) underwent menopause between ages 46 and 50, inclusive. Of participants who experienced menopause before age 41, between age 41 and 45, and between ages 46 and 50, 51%, 24%, and 7% (respectively) received either menopausal hormone therapy or hormonal contraception.Conclusion:These findings suggest that disparities in receipt of recommended hormone therapy for premature and early menopause may contribute, in part, to evident health disparities, such as cardiovascular disease, osteoporosis, and overall mortality. They also suggest a substantial need for education among people experiencing early menopause and their providers, with the goal of improving access to hormone therapy based on guidelines to address health disparities and minimize future health consequences.

AB - Objective:Little is known about the prevalence and treatment of premature and early menopause among people with HIV. We described premature and early menopause and subsequent hormonal treatment in a longitudinal cohort of women living with or at risk for HIV in the US.Methods:Data from the Women's Interagency HIV Study between 2008 and 2020 were analyzed to describe premature and early menopause among cohort participants under the age of 51.Results:Of 3,059 eligible women during the study period, 1% (n=35) underwent premature menopause before age 41, 3% (n=101) underwent menopause between ages 41 and 46, and 21% (n=442) underwent menopause between ages 46 and 50, inclusive. Of participants who experienced menopause before age 41, between age 41 and 45, and between ages 46 and 50, 51%, 24%, and 7% (respectively) received either menopausal hormone therapy or hormonal contraception.Conclusion:These findings suggest that disparities in receipt of recommended hormone therapy for premature and early menopause may contribute, in part, to evident health disparities, such as cardiovascular disease, osteoporosis, and overall mortality. They also suggest a substantial need for education among people experiencing early menopause and their providers, with the goal of improving access to hormone therapy based on guidelines to address health disparities and minimize future health consequences.

KW - Early menopause

KW - HIV

KW - Menopausal hormone therapy

KW - Premature menopause

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Premature and early menopause among US women with or at risk for HIV

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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