Premotor and nonmotor features of Parkinson's disease

Jennifer G Goldman*, Ron Postuma

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

176 Scopus citations

Abstract

PURPOSE OF REVIEW: This review highlights recent advances in premotor and nonmotor features in Parkinson's disease, focusing on these issues in the context of prodromal and early-stage Parkinson's disease. RECENT FINDINGS: Although Parkinson's disease patients experience a wide range of nonmotor symptoms throughout the disease course, studies demonstrate that nonmotor features are not solely a late manifestation. Indeed, disturbances of smell, sleep, mood, and gastrointestinal function may herald Parkinson's disease or related synucleinopathies and precede these neurodegenerative conditions by 5 or more years. In addition, other nonmotor symptoms such as cognitive impairment are now recognized in incident or de-novo Parkinson's disease cohorts. Many of these nonmotor features reflect disturbances in nondopaminergic systems and early involvement of peripheral and central nervous systems, including olfactory, enteric, and brainstem neurons as in Braak's proposed pathological staging of Parkinson's disease. Current research focuses on identifying potential biomarkers that may detect persons at risk for Parkinson's disease and permit early intervention with neuroprotective or disease-modifying therapeutics. SUMMARY: Recent studies provide new insights into the frequency, pathophysiology, and importance of nonmotor features in Parkinson's disease as well as the recognition that these nonmotor symptoms occur in premotor, early, and later phases of Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)434-441
Number of pages8
JournalCurrent Opinion in Neurology
Volume27
Issue number4
DOIs
StatePublished - Aug 2014

Keywords

  • autonomic
  • behavioral
  • cognitive
  • gastrointestinal
  • mood
  • sleep

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Premotor and nonmotor features of Parkinson's disease'. Together they form a unique fingerprint.

Cite this