Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers

Thomas A. Rizzo; Sharon L. Dooley; Boyd E. Metzger; Nam H. Cho; Edward S. Ogata; Bernard L. Silverman

doi:10.1016/0002-9378(95)90422-0

Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers

Thomas A. Rizzo^*, Sharon L. Dooley, Boyd E. Metzger, Nam H. Cho, Edward S. Ogata, Bernard L. Silverman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

OBJECTIVE: Our purpose was to assess to what extent disturbances in antepartum maternal metabolism and perinatal complications and morbidities contribute to poorer psychomotor development in offspring of diabetic mothers. STUDY DESIGN: One hundred ninety-six pregnant women and their singleton offspring participated in this prospective cohort-analytic study. Ninety-five women had pregestational diabetes mellitus, and 101 women had gestational diabetes mellitus. Serial estimates of circulating maternal fuels were obtained throughout each index pregnancy along with detailed records of the perinatal course and outcome. Offspring were administered the psychomotor development index of the Bayley Scales of Infant Development at age 2 years and the Bruininks-Oseretsky Test of Motor Proficiency at ages 6, 8, and 9 years. Tests were performed blinded to the mother's antepartum metabolic status, and perinatal history, and the child's previous test scores. Partial correlations and analyses of covariance were used to control for other influences and confounds, such as family socioeconomic status, racial or ethnic origin, patient group (i.e., pregestational or gestational diabetes mellitus), and sex of child. RESULTS: Children's average score on the Bruininks-Oseretsky test at ages 6 to 9 years correlated significantly with maternal second (p < 0.02) and third trimester (p < 0.001) β-hydroxybutyrate. There was also a borderline association between the children's scores on the psychomotor development index at age 2 years and maternal third-trimester β-hydroxybutyrate levels (p = 0.06). No other correlations approached significance. CONCLUSIONS: Intrauterine metabolic experiences continue to influence the neurodevelopmental course in offspring of diabetic mothers. Prevailing practices in diabetes management and obstetric and neonatal care appear to effectively mitigate the potential long-term effects of most perinatal complications and morbidities.

Original language	English (US)
Pages (from-to)	1753-1758
Number of pages	6
Journal	American journal of obstetrics and gynecology
Volume	173
Issue number	6
DOIs	https://doi.org/10.1016/0002-9378(95)90422-0
State	Published - 1995

Funding

From the Departments of Medicine, ~ Obstetrics and Gynecology,b and Pediatrics/ and the Diabetes in Pregnancy Center/ Northwestern Universit~ Medical School, Children's Memorial Hospital, and Northwestern Memorial Hospital (Prentice Women5 Hospital). supported in part by National Institutes of Health, awards No. DK10699, DK07169, HDll021, HD62903, HD23141, and RR48.

Keywords

Diabetes in pregnancy
child development
offspring of diabetic mothers
perinatal morbidities

ASJC Scopus subject areas

Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0002-9378(95)90422-0

Cite this

@article{a98b4a70712f462aa7ddd32aa56af384,

title = "Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers",

abstract = "OBJECTIVE: Our purpose was to assess to what extent disturbances in antepartum maternal metabolism and perinatal complications and morbidities contribute to poorer psychomotor development in offspring of diabetic mothers. STUDY DESIGN: One hundred ninety-six pregnant women and their singleton offspring participated in this prospective cohort-analytic study. Ninety-five women had pregestational diabetes mellitus, and 101 women had gestational diabetes mellitus. Serial estimates of circulating maternal fuels were obtained throughout each index pregnancy along with detailed records of the perinatal course and outcome. Offspring were administered the psychomotor development index of the Bayley Scales of Infant Development at age 2 years and the Bruininks-Oseretsky Test of Motor Proficiency at ages 6, 8, and 9 years. Tests were performed blinded to the mother's antepartum metabolic status, and perinatal history, and the child's previous test scores. Partial correlations and analyses of covariance were used to control for other influences and confounds, such as family socioeconomic status, racial or ethnic origin, patient group (i.e., pregestational or gestational diabetes mellitus), and sex of child. RESULTS: Children's average score on the Bruininks-Oseretsky test at ages 6 to 9 years correlated significantly with maternal second (p < 0.02) and third trimester (p < 0.001) β-hydroxybutyrate. There was also a borderline association between the children's scores on the psychomotor development index at age 2 years and maternal third-trimester β-hydroxybutyrate levels (p = 0.06). No other correlations approached significance. CONCLUSIONS: Intrauterine metabolic experiences continue to influence the neurodevelopmental course in offspring of diabetic mothers. Prevailing practices in diabetes management and obstetric and neonatal care appear to effectively mitigate the potential long-term effects of most perinatal complications and morbidities.",

keywords = "Diabetes in pregnancy, child development, offspring of diabetic mothers, perinatal morbidities",

author = "Rizzo, {Thomas A.} and Dooley, {Sharon L.} and Metzger, {Boyd E.} and Cho, {Nam H.} and Ogata, {Edward S.} and Silverman, {Bernard L.}",

note = "Funding Information: From the Departments of Medicine, ~ Obstetrics and Gynecology,b and Pediatrics/ and the Diabetes in Pregnancy Center/ Northwestern Universit~ Medical School, Children's Memorial Hospital, and Northwestern Memorial Hospital (Prentice Women5 Hospital). supported in part by National Institutes of Health, awards No. DK10699, DK07169, HDll021, HD62903, HD23141, and RR48.",

year = "1995",

doi = "10.1016/0002-9378(95)90422-0",

language = "English (US)",

volume = "173",

pages = "1753--1758",

journal = "American journal of obstetrics and gynecology",

issn = "0002-9378",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers

AU - Rizzo, Thomas A.

AU - Dooley, Sharon L.

AU - Metzger, Boyd E.

AU - Cho, Nam H.

AU - Ogata, Edward S.

AU - Silverman, Bernard L.

N1 - Funding Information: From the Departments of Medicine, ~ Obstetrics and Gynecology,b and Pediatrics/ and the Diabetes in Pregnancy Center/ Northwestern Universit~ Medical School, Children's Memorial Hospital, and Northwestern Memorial Hospital (Prentice Women5 Hospital). supported in part by National Institutes of Health, awards No. DK10699, DK07169, HDll021, HD62903, HD23141, and RR48.

PY - 1995

Y1 - 1995

N2 - OBJECTIVE: Our purpose was to assess to what extent disturbances in antepartum maternal metabolism and perinatal complications and morbidities contribute to poorer psychomotor development in offspring of diabetic mothers. STUDY DESIGN: One hundred ninety-six pregnant women and their singleton offspring participated in this prospective cohort-analytic study. Ninety-five women had pregestational diabetes mellitus, and 101 women had gestational diabetes mellitus. Serial estimates of circulating maternal fuels were obtained throughout each index pregnancy along with detailed records of the perinatal course and outcome. Offspring were administered the psychomotor development index of the Bayley Scales of Infant Development at age 2 years and the Bruininks-Oseretsky Test of Motor Proficiency at ages 6, 8, and 9 years. Tests were performed blinded to the mother's antepartum metabolic status, and perinatal history, and the child's previous test scores. Partial correlations and analyses of covariance were used to control for other influences and confounds, such as family socioeconomic status, racial or ethnic origin, patient group (i.e., pregestational or gestational diabetes mellitus), and sex of child. RESULTS: Children's average score on the Bruininks-Oseretsky test at ages 6 to 9 years correlated significantly with maternal second (p < 0.02) and third trimester (p < 0.001) β-hydroxybutyrate. There was also a borderline association between the children's scores on the psychomotor development index at age 2 years and maternal third-trimester β-hydroxybutyrate levels (p = 0.06). No other correlations approached significance. CONCLUSIONS: Intrauterine metabolic experiences continue to influence the neurodevelopmental course in offspring of diabetic mothers. Prevailing practices in diabetes management and obstetric and neonatal care appear to effectively mitigate the potential long-term effects of most perinatal complications and morbidities.

AB - OBJECTIVE: Our purpose was to assess to what extent disturbances in antepartum maternal metabolism and perinatal complications and morbidities contribute to poorer psychomotor development in offspring of diabetic mothers. STUDY DESIGN: One hundred ninety-six pregnant women and their singleton offspring participated in this prospective cohort-analytic study. Ninety-five women had pregestational diabetes mellitus, and 101 women had gestational diabetes mellitus. Serial estimates of circulating maternal fuels were obtained throughout each index pregnancy along with detailed records of the perinatal course and outcome. Offspring were administered the psychomotor development index of the Bayley Scales of Infant Development at age 2 years and the Bruininks-Oseretsky Test of Motor Proficiency at ages 6, 8, and 9 years. Tests were performed blinded to the mother's antepartum metabolic status, and perinatal history, and the child's previous test scores. Partial correlations and analyses of covariance were used to control for other influences and confounds, such as family socioeconomic status, racial or ethnic origin, patient group (i.e., pregestational or gestational diabetes mellitus), and sex of child. RESULTS: Children's average score on the Bruininks-Oseretsky test at ages 6 to 9 years correlated significantly with maternal second (p < 0.02) and third trimester (p < 0.001) β-hydroxybutyrate. There was also a borderline association between the children's scores on the psychomotor development index at age 2 years and maternal third-trimester β-hydroxybutyrate levels (p = 0.06). No other correlations approached significance. CONCLUSIONS: Intrauterine metabolic experiences continue to influence the neurodevelopmental course in offspring of diabetic mothers. Prevailing practices in diabetes management and obstetric and neonatal care appear to effectively mitigate the potential long-term effects of most perinatal complications and morbidities.

KW - Diabetes in pregnancy

KW - child development

KW - offspring of diabetic mothers

KW - perinatal morbidities

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AN - SCOPUS:0029616152

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JO - American journal of obstetrics and gynecology

JF - American journal of obstetrics and gynecology

IS - 6

ER -

Prenatal and perinatal influences on long-term psychomotor development in offspring of diabetic mothers

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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