Prenatal antibiotic treatment does not decrease group B streptococcus colonization at delivery

Laura Baecher*, William Grobman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objective: To evaluate whether an outpatient antibiotic regimen decreased group B streptococcal (GBS) colonization to preclude the use of intrapartum antibiotics. Methods: A double-blind randomized controlled trial evaluating prenatal oral amoxicillin versus placebo with the primary outcome of GBS colonization at the time of labor. Results: Of those patients receiving both amoxicillin and a repeat culture at the time of labor, 6 of the 14 (43%) tested positive for GBS colonization. Given persistent GBS colonization of 67% (10/15) in the placebo group, treatment with amoxicillin did not significantly impact colonization at the time of delivery (P = 0.20). Conclusion: A regimen of outpatient amoxicillin was associated with persistent GBS colonization in 43% of women at the time of labor. Oral prenatal antibiotic prophylaxis against GBS does not sufficiently reduce colonization to preclude intrapartum intravenous antibiotics.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Issue number2
StatePublished - May 2008


  • Amoxicillin;
  • Group B streptococcus;
  • Intrapartum prophylaxis;
  • Prenatal prophylaxis

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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