@article{bb327e8261d64471b3b2dd9d03853d06,
title = "Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study",
abstract = "Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data from the Environmental influences on Child Health Outcomes (ECHO) program (N = 3129) to test for this association, and determine whether the association remained after adjusting for maternal prenatal depression and other potential confounders. Antidepressants and a subset of selective serotonin reuptake inhibitors (SSRIs) were examined in relation to binary (e.g., diagnostic) and continuous measures of ASD and ASD related traits (e.g., social difficulties, behavior problems) in children 1.5 to 12 years of age. Child sex was tested as an effect modifier. While prenatal antidepressant exposure was associated with ASD related traits in univariate analyses, these associations were statistically non-significant in models that adjusted for prenatal maternal depression and other maternal and child characteristics. Sex assigned at birth was not an effect modifier for the prenatal antidepressant and child ASD relationship. Overall, we found no association between prenatal antidepressant exposures and ASD diagnoses or traits. Discontinuation of antidepressants in pregnancy does not appear to be warranted on the basis of increased risk for offspring ASD.",
keywords = "Antidepressants, Autism spectrum disorder, Neurodevelopment, Prenatal",
author = "Brennan, {Patricia A.} and Dunlop, {Anne L.} and Croen, {Lisa A.} and Avalos, {Lyndsay A.} and Salisbury, {Amy L.} and Hipwell, {Alison E.} and Nozadi, {Sara S.} and Sheela Sathyanarayana and Crum, {Rosa M.} and Rashelle Musci and Mingyi Li and Xiuhong Li and Maxwell Mansolf and O{\textquoteright}Connor, {Thomas G.} and Elliott, {Amy J.} and Nidhi Ghildayal and Lin, {Pi I.D.} and Sprowles, {Jenna L.N.} and Stanford, {Joseph B.} and Casper Bendixsen and Sally Ozonoff and Lester, {Barry M.} and Shuster, {Coral L.} and Huddleston, {Kathi C.} and Jonathan Posner and Nigel Paneth",
note = "Funding Information: The authors wish to thank our ECHO colleagues; the medical, nursing, and program staff; and the children and families participating in the ECHO cohorts. We also acknowledge the contribution of the following ECHO program collaborators: ECHO Components—Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Smith PB, Newby KL; Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Parker CB; Person-Reported Outcomes Core: Northwestern University, Evanston, Illinois: Gershon R, Cella D; ECHO Awardees and Cohorts: Albert Einstein College of Medicine, Bronx, New York: Aschner J; Icahn School of Medicine at Mount Sinai, New York, NY: Teitelbaum SL; Stroustrup A; Cohen Children{\textquoteright}s Medical Center, Northwell Health: Stroustrup A; Cincinnati Children{\textquoteright}s Hospital Medical Center, Cincinnati, Ohio: Merhar S; Children{\textquoteright}s Hospital and Clinic Minnesota, Minneapolis, MN: Lampland A; University of Buffalo, Buffalo, NY: Reynolds A; University of Florida, College of Medicine, Jacksonville, FL: Hudak M; University of Rochester Medical Center, Rochester, NY: Pryhuber G; Vanderbilt Children{\textquoteright}s Hospital, Nashville, TN: Moore P; Wake Forest University School of Medicine, Winston Salem, NC: Washburn L; Memorial Hospital of Rhode Island, Providence RI: Deoni S; New York State Psychiatric Institute, New York, NY: Duarte C; University of Puerto Rico, San Jaun, PR: Canino G; University of Wisconsin, Madison WI: Gern J; University of California Davis Mind Institute, Sacramento, CA: Hertz-Picciotto I; University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA: Karr C; Children{\textquoteright}s Mercy, Kansas City, MO: Carter B; Emory University, Atlanta, GA: Marsit C; Helen DeVos Children{\textquoteright}s Hospital, Grand Rapids, MI: Pastyrnak S; Kapiolani Medical Center for Women and Children, Providence, RI: Neal C; Los Angeles Biomedical Research Institute at Harbour-UCLA Medical Center, Los Angeles CA: Smith L; Wake Forest University School of Medicine, Winston Salem, NC: Helderman J; Pennsylvania State University, University Park, PA: Lyall K; Johns Hopkins Bloomberg School of Public Health Kennedy Krieger Institute, Baltimore, MD: Landa R; University of Pittsburgh Medical Center, Magee Women{\textquoteright}s Hospital, Pittsburgh, PA: Simhan H; Harvard Pilgrim Health Care Institute, Boston, MA: Oken E; Michigan State University, East Lansing, MI: Kerver J; Henry Ford Health System, Detroit, MI: Barone, C; Michigan Department of Health and Human Services, Lansing, MI: McKane, P; University of Michigan, Ann Arbor, MI: Elliott, M; University of Illinois, Beckman Institute, Urbana, IL: Schantz S; New York School of Medicine, New York, NY: Trasande L; Icahn School of Medicine at Mount Sinai, New York, NY: Wright R; Boston Children{\textquoteright}s Hospital, Boston MA: Bosquet-Enlow M; University of California, San Francisco, San Francisco CA: Bush N; University of Minnesota, Minneapolis, MN: Nguyen R; University of Rochester Medical Center: Rochester, NY: Barrett E. Funding Information: The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this publication was supported by the Environmental influences on Child Health Outcomes (ECHO) program, Office of the Director, National Institutes of Health, under Award Numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (PRO Core), UH3OD023318 (Dunlop/Brennan), UH3OD023347 (Lester), UH3OD023279 (Elliott), UH3OD023313 (Deoni), UH3OD023286 (Oken), UH3OD023320 (Aschner), UH3OD023365 (Hertz-Picciotto), UH3OD023271 (Karr), UH3OD023272 (Schantz), UH3OD023285 (Kerver), UH3OD023249 (Stanford), UH3OD023337 (Wright), UH3OD023282 (Gern), UH3OD023342 (Lyall), UH3OD023305 (Trasande), UH3OD023328 (Duarte), UH3OD023349 (O{\textquoteright}Connor), UH3OD023244 (Hipwell). Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/s10802-022-01000-5",
language = "English (US)",
volume = "51",
pages = "513--527",
journal = "Research on Child and Adolescent Psychopathology",
issn = "2730-7166",
publisher = "Springer New York",
number = "4",
}
