TY - JOUR
T1 - Prenatal cocaine
T2 - Effect on hypoxic ventilatory responsiveness in neonatal rats
AU - Lipton, Jack W.
AU - Davidson, Teresa L.
AU - Carvey, Paul M.
AU - Weese-Mayer, Debra E.
PY - 1996/11/1
Y1 - 1996/11/1
N2 - The effects of prenatal (embryonic days 7-21) cocaine (30 mg/kg b.i.d., s.c.) exposure on postnatal respiratory and behavioral responsiveness to acute hypoxia were investigated in 5-day-old (P5) rat pups. Control and cocaine-exposed pups were subjected to 20 min of 0.21 FI(O2) followed by 20 min of 0.08 FI(O2). Although all pups demonstrated the characteristic biphasic response to hypoxia, cocaine-exposed pups exhibited a blunted, initial response in minute ventilation (p < 0.05) and inspiratory drive (p < 0.05) as compared with control pups who showed increases in these measures (p < 0.01 and p < 0.05, respectively). The consequence of this apparent blunted ventilatory response was reflected in blood gas data gathered after 20 min of 0.08 FI(O2): P(CO2) (p < 0.05) and base-excess (p < 0.05) were increased and HCO3- (p < 0.05) and S(O2) (p < 0.001) were decreased relative to control pups. Cocaine-exposed pups also exhibited behavioral evidence of decreased struggling (p < 0.001) in response to the hypoxic challenge. These data in the rat confirm our previous findings of altered ventilatory responsiveness to inspired hypoxia in the rabbit and extend our observations of a decreased ability to successfully compensate and behaviorally arouse following prenatal cocaine-exposure, thus underscoring the potential vulnerability of infants so exposed.
AB - The effects of prenatal (embryonic days 7-21) cocaine (30 mg/kg b.i.d., s.c.) exposure on postnatal respiratory and behavioral responsiveness to acute hypoxia were investigated in 5-day-old (P5) rat pups. Control and cocaine-exposed pups were subjected to 20 min of 0.21 FI(O2) followed by 20 min of 0.08 FI(O2). Although all pups demonstrated the characteristic biphasic response to hypoxia, cocaine-exposed pups exhibited a blunted, initial response in minute ventilation (p < 0.05) and inspiratory drive (p < 0.05) as compared with control pups who showed increases in these measures (p < 0.01 and p < 0.05, respectively). The consequence of this apparent blunted ventilatory response was reflected in blood gas data gathered after 20 min of 0.08 FI(O2): P(CO2) (p < 0.05) and base-excess (p < 0.05) were increased and HCO3- (p < 0.05) and S(O2) (p < 0.001) were decreased relative to control pups. Cocaine-exposed pups also exhibited behavioral evidence of decreased struggling (p < 0.001) in response to the hypoxic challenge. These data in the rat confirm our previous findings of altered ventilatory responsiveness to inspired hypoxia in the rabbit and extend our observations of a decreased ability to successfully compensate and behaviorally arouse following prenatal cocaine-exposure, thus underscoring the potential vulnerability of infants so exposed.
KW - Development, hypoxic response
KW - Drugs, cocaine
KW - Hypoxia, postnatal response on prenatal cocaine
KW - Mammals, rat
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U2 - 10.1016/S0034-5687(96)00075-8
DO - 10.1016/S0034-5687(96)00075-8
M3 - Article
C2 - 8971989
AN - SCOPUS:0030297337
VL - 106
SP - 161
EP - 169
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 2
ER -