To the Editor: We wish to report a midtrimester prenatal diagnosis by ultrasonography of congenital muscular dystrophy producing arthrogryposis. The proband was a 2875-g female infant born at term to healthy, unrelated parents of Northern European origin. The pregnancy had been uncomplicated except for the mother's recollection of the absence of fetal movement. The infant was delivered by cesarean section because of fetal distress. She had Apgar scores of 3 and 4 at one and five minutes, respectively, had multiple external compression deformities and contractures, and died of respiratory failure two hours after birth. At autopsy, skeletal muscle was found.
ASJC Scopus subject areas