Prenatal undernutrition and postnatal growth are associated with adolescent thymic function

Thomas W. McDade*, Melinda A. Beck, Christopher W. Kuzawa, Linda S. Adair

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

The fetal and early infant origins of a number of adult cardiovascular and metabolic diseases have received considerable attention, but the long-term consequences of early environments for human immune function have not been reported. We investigated the effects of pre- and postnatal environments on thymic hormone production in adolescents participating in an ongoing longitudinal study in the Philippines. Prospective data collected at birth, during y 1 of life, in childhood and in adolescence were used to predict plasma thymopoietin concentration in 14- to 15-y-old adolescents (n = 103). Thymopoietin concentration was compared for small-for-gestational-age and appropriate-for-gestational-age individuals while controlling for a range of postnatal exposures. Prenatal undernutrition was significantly associated with reduced thymopoietin production in interaction with the duration of exclusive breast-feeding (P = 0.006). Growth in length during y 1 of life was positively associated with adolescent thymopoietin production (P = 0.002). These associations remained significant after adjusting for a range of potentially confounding variables. These findings provide support for the importance of fetal and early infant programming of thymic function, and suggest that early environments may have long-term implications for immunocompetence and adult disease risk.

Original languageEnglish (US)
Pages (from-to)1225-1231
Number of pages7
JournalJournal of Nutrition
Volume131
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Growth and development
  • Humans
  • Immune system
  • Nutrition
  • Prenatal exposure delayed effects
  • Thymic factor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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