Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results

Merrill S. Kies; Bernard C. Pecaro; Leo I. Gordon; Walter W. Hauck; Michael J. Kraut; Yosef Krespl; Robert H. Ossoff; Cynthia Schiff; Ramananda Shetty; George A. Sisson

doi:10.1016/0002-9610(84)90473-2

Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results

Merrill S. Kies^*, Bernard C. Pecaro, Leo I. Gordon, Walter W. Hauck, Michael J. Kraut, Yosef Krespl, Robert H. Ossoff, Cynthia Schiff, Ramananda Shetty, George A. Sisson

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We treated 19 consecutive patients with cisplatin, bleomycin, and methotrexate before definitive surgery or radiation therapy. Fourteen patients (74 percent) had partial or complete tumor regression after chemotherapy. With a minimum follow-up time of 27 months, none of the 4 patients who had a major histologic response relapsed, and only 2 of the remaining 15 patients continued disease-free. The achievement of a complete histologic response after preoperative chemotherapy may correlate with long-term disease-free survival after surgery and radiation therapy for head and neck cancer.

Original language	English (US)
Pages (from-to)	367-371
Number of pages	5
Journal	The American Journal of Surgery
Volume	148
Issue number	3
DOIs	https://doi.org/10.1016/0002-9610(84)90473-2
State	Published - Sep 1984

ASJC Scopus subject areas

Surgery

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title = "Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results",

abstract = "We treated 19 consecutive patients with cisplatin, bleomycin, and methotrexate before definitive surgery or radiation therapy. Fourteen patients (74 percent) had partial or complete tumor regression after chemotherapy. With a minimum follow-up time of 27 months, none of the 4 patients who had a major histologic response relapsed, and only 2 of the remaining 15 patients continued disease-free. The achievement of a complete histologic response after preoperative chemotherapy may correlate with long-term disease-free survival after surgery and radiation therapy for head and neck cancer.",

author = "Kies, {Merrill S.} and Pecaro, {Bernard C.} and Gordon, {Leo I.} and Hauck, {Walter W.} and Kraut, {Michael J.} and Yosef Krespl and Ossoff, {Robert H.} and Cynthia Schiff and Ramananda Shetty and Sisson, {George A.}",

year = "1984",

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doi = "10.1016/0002-9610(84)90473-2",

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TY - JOUR

T1 - Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results

AU - Kies, Merrill S.

AU - Pecaro, Bernard C.

AU - Gordon, Leo I.

AU - Hauck, Walter W.

AU - Kraut, Michael J.

AU - Krespl, Yosef

AU - Ossoff, Robert H.

AU - Schiff, Cynthia

AU - Shetty, Ramananda

AU - Sisson, George A.

PY - 1984/9

Y1 - 1984/9

N2 - We treated 19 consecutive patients with cisplatin, bleomycin, and methotrexate before definitive surgery or radiation therapy. Fourteen patients (74 percent) had partial or complete tumor regression after chemotherapy. With a minimum follow-up time of 27 months, none of the 4 patients who had a major histologic response relapsed, and only 2 of the remaining 15 patients continued disease-free. The achievement of a complete histologic response after preoperative chemotherapy may correlate with long-term disease-free survival after surgery and radiation therapy for head and neck cancer.

AB - We treated 19 consecutive patients with cisplatin, bleomycin, and methotrexate before definitive surgery or radiation therapy. Fourteen patients (74 percent) had partial or complete tumor regression after chemotherapy. With a minimum follow-up time of 27 months, none of the 4 patients who had a major histologic response relapsed, and only 2 of the remaining 15 patients continued disease-free. The achievement of a complete histologic response after preoperative chemotherapy may correlate with long-term disease-free survival after surgery and radiation therapy for head and neck cancer.

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Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results

Abstract

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