Preoperative combination chemotherapy for advanced stage head and neck cancer. Promising early results

Merrill S. Kies*, Bernard C. Pecaro, Leo I. Gordon, Walter W. Hauck, Michael J. Kraut, Yosef Krespl, Robert H. Ossoff, Cynthia Schiff, Ramananda Shetty, George A. Sisson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We treated 19 consecutive patients with cisplatin, bleomycin, and methotrexate before definitive surgery or radiation therapy. Fourteen patients (74 percent) had partial or complete tumor regression after chemotherapy. With a minimum follow-up time of 27 months, none of the 4 patients who had a major histologic response relapsed, and only 2 of the remaining 15 patients continued disease-free. The achievement of a complete histologic response after preoperative chemotherapy may correlate with long-term disease-free survival after surgery and radiation therapy for head and neck cancer.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalThe American Journal of Surgery
Volume148
Issue number3
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Surgery

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