Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population

Mohamed A. Soliman Hamad*, Albert H.M. van Straten, Jacques P.A.M. Schönberger, Joost F. ter Woorst, Andre M. de Wolf, Elisabeth J. Martens, André A.J. van Zundert

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Preoperative left ventricular dysfunction is an established risk factor for early and late mortality after revascularization. This retrospective analysis demonstrates the effects of preoperative ejection fraction on the short-term and long-term survival of patients after coronary artery bypass grafting.Methods: Early and late mortality were determined retrospectively in 10 626 consecutive patients who underwent isolated coronary bypass between January 1998 and December 2007. The subjects were divided into 3 groups according to their preoperative ejection fraction. Expected survival was estimated by comparison with a general Dutch population group described in the database of the Dutch Central Bureau for Statistics. For each of our groups with a known preoperative ejection fraction, a general Dutch population group was matched for age, sex, and year of operation.Results and Discussion: One hundred twenty-two patients were lost to follow-up. In 219 patients, the preoperative ejection fraction could not be retrieved. In the remaining patients (n = 10 285), the results of multivariate logistic regression and Cox regression analysis identified the ejection fraction as a predictor of early and late mortality. When we compared long-term survival and expected survival, we found a relatively poorer outcome in all subjects with an ejection fraction of < 50%. In subjects with a preoperative ejection fraction of > 50%, long-term survival exceeded expected survival.Conclusions: The severity of left ventricular dysfunction was associated with poor survival. Compared with the survival of the matched general population, our coronary bypass patients had a worse outcome only if their preoperative ejection fraction was < 50%.

Original languageEnglish (US)
Article number29
JournalJournal of Cardiothoracic Surgery
Volume5
Issue number1
DOIs
StatePublished - Apr 23 2010

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population'. Together they form a unique fingerprint.

  • Cite this

    Soliman Hamad, M. A., van Straten, A. H. M., Schönberger, J. P. A. M., ter Woorst, J. F., de Wolf, A. M., Martens, E. J., & van Zundert, A. A. J. (2010). Preoperative ejection fraction as a predictor of survival after coronary artery bypass grafting: comparison with a matched general population. Journal of Cardiothoracic Surgery, 5(1), [29]. https://doi.org/10.1186/1749-8090-5-29