Preoperative predictors of survival after resection of small hepatocellular carcinomas

Jeffrey D. Wayne, Gregory Y. Lauwers, Iwao Ikai, Dorota A. Doherty, Jacques Belghiti, Yoshio Yamaoka, Jean Marc Regimbeau, David M. Nagorney, Kim Anh Do, Lee M. Ellis, Steven A. Curley, Raphael E. Pollock, Jean Nicolas Vauthey*

*Corresponding author for this work

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

Objective: To determine preoperative predictors of survival that can guide the choice of treatment for patients with small hepatocellular cancers (HCCs). Summary Background Data: The treatment of patients with small (≤5 cm in diameter) HCCs is controversial. Methods: A cohort of 249 patients (69 women, 180 men; median age 62 years) who underwent resection with curative intent for small HCC was identified from a multiinstitutional database. For each patient, the clinical data and pathology slides were reviewed. Six clinical factors (age, gender, preoperative α-fetoprotein level, hepatitis serology, number of tumors [single vs. multiple], and Child-Pugh score) and three pathologic factors (hepatitis activity score, fibrosis score, and Edmondson-Steiner tumor grade) that can be determined before surgery were correlated with survival. Log-rank tests and Cox proportional hazards modeling were used to determine factors influencing survival. Results: The median overall survival for the entire cohort was 4.2 years. The estimated overall 5- and 8-year survival rates were 41.1 % and 19.8%, respectively. Multivariate Cox analysis indicated that fibrosis score, Edmondson-Steiner grade, and Child-Pugh score were simultaneously significant predictors of survival after resection. A prognostic scoring system based on these covariates was derived and applied to the entire cohort. Patients lacking all three risk factors were assigned a score of 1, patients with one risk factor were assigned a score of 2, and patients with two or three risk factors were assigned a score of 3. Pairwise log-rank tests indicated significant differences in survival between scores 1 and 2, scores 2 and 3, and scores 1 and 3. This scoring system retained its prognostic significance when a subset of 98 patients with positive hepatitis C serology was analyzed separately. Conclusions: Patients with small HCCs who will derive the least benefit from resection can be identified before surgery using a score based on tumor grade and the severity of underlying liver disease. In these patients, transplantation and/or ablation should be considered as possible alternative therapies.

Original languageEnglish (US)
Pages (from-to)722-731
Number of pages10
JournalAnnals of surgery
Volume235
Issue number5
DOIs
StatePublished - May 9 2002

ASJC Scopus subject areas

  • Surgery

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    Wayne, J. D., Lauwers, G. Y., Ikai, I., Doherty, D. A., Belghiti, J., Yamaoka, Y., Regimbeau, J. M., Nagorney, D. M., Do, K. A., Ellis, L. M., Curley, S. A., Pollock, R. E., & Vauthey, J. N. (2002). Preoperative predictors of survival after resection of small hepatocellular carcinomas. Annals of surgery, 235(5), 722-731. https://doi.org/10.1097/00000658-200205000-00015