Preparation and biodistribution of new apoptosis imaging regent 99mTc-FM-2

Shundong Ji; Wei Fang; Jundong Zhou; Zuoxiang He; Xiujie Liu; Changgeng Ruan; Ming Zhao

Preparation and biodistribution of new apoptosis imaging regent ^99mTc-FM-2

Shundong Ji^*, Wei Fang, Jundong Zhou, Zuoxiang He, Xiujie Liu, Changgeng Ruan, Ming Zhao

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

FM-2 was modified with 2-iminotholane and labeled with ⁹⁹Tc^m-GH. The radiochemical purity of ^99mTc-FM-2 was over 95% and can stable in the routine temperature for more than 8 hours. Biodistribution in mice showed ^99mTc-FM-2 was cleared mainly by liver and kidney. The normal myocardial showed a high uptake and rapid clearance of ^99mTc-FM-2.

Original language	English (US)
Pages (from-to)	679-682
Number of pages	4
Journal	He Jishu/Nuclear Techniques
Volume	30
Issue number	8
State	Published - Aug 1 2007

Keywords

Apoptosis
Biodistribution
Synaptotagmin I
Technetium

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Nuclear Energy and Engineering

Cite this

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title = "Preparation and biodistribution of new apoptosis imaging regent 99mTc-FM-2",

abstract = "FM-2 was modified with 2-iminotholane and labeled with 99Tcm-GH. The radiochemical purity of 99mTc-FM-2 was over 95% and can stable in the routine temperature for more than 8 hours. Biodistribution in mice showed 99mTc-FM-2 was cleared mainly by liver and kidney. The normal myocardial showed a high uptake and rapid clearance of 99mTc-FM-2.",

keywords = "Apoptosis, Biodistribution, Synaptotagmin I, Technetium",

author = "Shundong Ji and Wei Fang and Jundong Zhou and Zuoxiang He and Xiujie Liu and Changgeng Ruan and Ming Zhao",

year = "2007",

month = aug,

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language = "English (US)",

volume = "30",

pages = "679--682",

journal = "He Jishu/Nuclear Techniques",

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TY - JOUR

T1 - Preparation and biodistribution of new apoptosis imaging regent 99mTc-FM-2

AU - Ji, Shundong

AU - Fang, Wei

AU - Zhou, Jundong

AU - He, Zuoxiang

AU - Liu, Xiujie

AU - Ruan, Changgeng

AU - Zhao, Ming

PY - 2007/8/1

Y1 - 2007/8/1

N2 - FM-2 was modified with 2-iminotholane and labeled with 99Tcm-GH. The radiochemical purity of 99mTc-FM-2 was over 95% and can stable in the routine temperature for more than 8 hours. Biodistribution in mice showed 99mTc-FM-2 was cleared mainly by liver and kidney. The normal myocardial showed a high uptake and rapid clearance of 99mTc-FM-2.

AB - FM-2 was modified with 2-iminotholane and labeled with 99Tcm-GH. The radiochemical purity of 99mTc-FM-2 was over 95% and can stable in the routine temperature for more than 8 hours. Biodistribution in mice showed 99mTc-FM-2 was cleared mainly by liver and kidney. The normal myocardial showed a high uptake and rapid clearance of 99mTc-FM-2.

KW - Apoptosis

KW - Biodistribution

KW - Synaptotagmin I

KW - Technetium

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M3 - Article

AN - SCOPUS:34548482924

SN - 0253-3219

VL - 30

SP - 679

EP - 682

JO - He Jishu/Nuclear Techniques

JF - He Jishu/Nuclear Techniques

IS - 8

ER -

Preparation and biodistribution of new apoptosis imaging regent ^99mTc-FM-2

Abstract

Keywords

ASJC Scopus subject areas

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