Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer

Fengqin Hu*, Li Wei, Zhuan Zhou, Yuliang Ran, Zhen Li, Mingyuan Gao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

385 Scopus citations

Abstract

The preparation of biocompatible magnetite nanocrystals for magnetic resonance detection of cancer, was investigated. The strategy is to replace the commonly used nonpolar high-boiling point solvents by 2-pyrolidone, which can also serve as a coordinating solvent in addition to high-temperature reaction medium. The biocompatible Fe3O4 nanocrystals was prepared by covalently modifying the Fe3O4 nanocrystals with monocarboxyl-terminated poly (ethylene glycol) (PEG)through its carboxylic group. Magnetic resonance imaging (MRI) results demonstrate that the resultant bioconjugates could effectively target cancer cell for both in vitro and in vivo detection. It was also observed that the biocompatible Fe3O 4 nanocrystals prepared could be used as MRI contrast agents for magnetic resonance molecular imaging.

Original languageEnglish (US)
Pages (from-to)2553-2556
Number of pages4
JournalAdvanced Materials
Volume18
Issue number19
DOIs
StatePublished - Oct 4 2006

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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