Preparation of [14C]G2.5 and [14C]G5.5 Starburst® PAMAM dendrimers: The first example of dendrimer radiosynthesis

Brad D. Maxwell*, Hideji Fujiwara, Sohrab Habibi-Goudarzi, Justin P. Ortiz, Sherry J. Logusch

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A procedure for preparing 14C-labelled half-generation Starburst® PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with 14C-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmol in very high radiochemical purity.

Original languageEnglish (US)
Pages (from-to)935-939
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume41
Issue number10
DOIs
StatePublished - Oct 1 1998

Keywords

  • C-labelled half-generation Starburst® PAMAM dendrimers
  • Synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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