Preparation of [14C]G2.5 and [14C]G5.5 Starburst® PAMAM dendrimers: The first example of dendrimer radiosynthesis

Brad D. Maxwell; Hideji Fujiwara; Sohrab Habibi-Goudarzi; Justin P. Ortiz; Sherry J. Logusch

doi:10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S

Preparation of [¹⁴C]G2.5 and [¹⁴C]G5.5 Starburst® PAMAM dendrimers: The first example of dendrimer radiosynthesis

Brad D. Maxwell^*, Hideji Fujiwara, Sohrab Habibi-Goudarzi, Justin P. Ortiz, Sherry J. Logusch

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

A procedure for preparing ¹⁴C-labelled half-generation Starburst® PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with ¹⁴C-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmol in very high radiochemical purity.

Original language	English (US)
Pages (from-to)	935-939
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	41
Issue number	10
DOIs	https://doi.org/10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S
State	Published - Oct 1 1998

Keywords

C-labelled half-generation Starburst® PAMAM dendrimers
Synthesis

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S

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Maxwell, B. D., Fujiwara, H., Habibi-Goudarzi, S., Ortiz, J. P., & Logusch, S. J. (1998). Preparation of [¹⁴C]G2.5 and [¹⁴C]G5.5 Starburst® PAMAM dendrimers: The first example of dendrimer radiosynthesis. Journal of Labelled Compounds and Radiopharmaceuticals, 41(10), 935-939. https://doi.org/10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S

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