Preparation of [14C]G2.5 and [14C]G5.5 Starburst® PAMAM dendrimers: The first example of dendrimer radiosynthesis

Brad D. Maxwell; Hideji Fujiwara; Sohrab Habibi-Goudarzi; Justin P. Ortiz; Sherry J. Logusch

doi:10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S

Preparation of [¹⁴C]G2.5 and [¹⁴C]G5.5 Starburst® PAMAM dendrimers: The first example of dendrimer radiosynthesis

Brad D. Maxwell^*, Hideji Fujiwara, Sohrab Habibi-Goudarzi, Justin P. Ortiz, Sherry J. Logusch

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A procedure for preparing ¹⁴C-labelled half-generation Starburst® PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with ¹⁴C-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmol in very high radiochemical purity.

Original language	English (US)
Pages (from-to)	935-939
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	41
Issue number	10
DOIs	https://doi.org/10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S
State	Published - Oct 1998

Keywords

C-labelled half-generation Starburst® PAMAM dendrimers
Synthesis

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/(SICI)1099-1344(1998100)41:10<935::AID-JLCR146>3.0.CO;2-S

Cite this

@article{2ee6fed4ffd049d199deadeaad694a08,

title = "Preparation of [14C]G2.5 and [14C]G5.5 Starburst{\textregistered} PAMAM dendrimers: The first example of dendrimer radiosynthesis",

abstract = "A procedure for preparing 14C-labelled half-generation Starburst{\textregistered} PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with 14C-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmol in very high radiochemical purity.",

keywords = "C-labelled half-generation Starburst{\textregistered} PAMAM dendrimers, Synthesis",

author = "Maxwell, {Brad D.} and Hideji Fujiwara and Sohrab Habibi-Goudarzi and Ortiz, {Justin P.} and Logusch, {Sherry J.}",

year = "1998",

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journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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T1 - Preparation of [14C]G2.5 and [14C]G5.5 Starburst® PAMAM dendrimers

T2 - The first example of dendrimer radiosynthesis

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AU - Fujiwara, Hideji

AU - Habibi-Goudarzi, Sohrab

AU - Ortiz, Justin P.

AU - Logusch, Sherry J.

PY - 1998/10

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N2 - A procedure for preparing 14C-labelled half-generation Starburst® PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with 14C-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmol in very high radiochemical purity.

AB - A procedure for preparing 14C-labelled half-generation Starburst® PAMAM dendrimers is described. Controlled incorporation of radioisotope was achieved by Michael additions of amines with 14C-labelled methyl acrylate, resulting in dendrimers with specific activities between 30 and 45 mCi/mmol in very high radiochemical purity.

KW - C-labelled half-generation Starburst® PAMAM dendrimers

KW - Synthesis

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