Prerandomization: An alternative to classic randomization. The effects on recruitment in a controlled trial of arthroscopy for osteoarthrosis of the knee

Rowland W Chang*, J. Falconer, S. D. Stulberg, W. J. Arnold, Alan Richard Dyer

*Corresponding author for this work

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Possibly the greatest threat to the success of a randomized clinical trial is the inability to recruit an adequate number of subjects. Concern that the randomized clinical trial will adversely affect the physician-patient relationship is the most common reason for physicians' reluctance to enroll patients in such trials. We report a modification of a prerandomized design, first described by Zelen, which was implemented in a randomized clinical trial of arthroscopy for patients who had osteoarthrosis of the knee. The method was associated with a sixfold increase in the rate of accrual of patients as compared with the use of a classic randomization trial. We propose the design as a potential solution to the problem of recruitment of subjects, particularly for clinical studies.

Original languageEnglish (US)
Pages (from-to)1451-1455
Number of pages5
JournalJournal of Bone and Joint Surgery - Series A
Volume72 A
Issue number10
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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