Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome

Sarah B. Mulkey; Colleen Peyton; Emily Ansusinha; Elizabeth Corn; Margarita Arroyave-Wessel; Anqing Zhang; Cara Biddle; Corina Gutierrez; Andrea Sorkar; Andres Cure; Daniela Cure; Adre J. du Plessis; Roberta L. DeBiasi; Michael E. Msall; Carlos Cure

doi:10.1038/s41390-022-02373-5

Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome

Sarah B. Mulkey^*, Colleen Peyton, Emily Ansusinha, Elizabeth Corn, Margarita Arroyave-Wessel, Anqing Zhang, Cara Biddle, Corina Gutierrez, Andrea Sorkar, Andres Cure, Daniela Cure, Adre J. du Plessis, Roberta L. DeBiasi, Michael E. Msall, Carlos Cure

^*Corresponding author for this work

Physical Therapy and Human Movement Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Children with in utero Zika virus (ZIKV) exposure without congenital Zika syndrome (CZS) are at risk for abnormal neurodevelopment. Preschool-age outcomes for children with antenatal ZIKV exposure have not yet been established. Methods: Children with in utero ZIKV exposure and non-exposed controls had neurodevelopmental evaluations at age 3–5 years in Sabanalarga, Colombia. Cases did not have CZS and were previously evaluated prenatally through age 18 months. Controls were born before ZIKV arrival to Colombia. Neurodevelopmental assessments included Pediatric Evaluation of Disability Inventory (PEDI-CAT), Behavior Rating Inventory of Executive Function (BRIEF-P), Bracken School Readiness Assessment (BSRA), and Movement Assessment Battery for Children (MABC). Family demographics and child medical history were recorded. Results: Fifty-five ZIKV-exposed children were evaluated at mean age 3.6 years and 70 controls were evaluated at 5.2 years. Family demographics were similar between groups. BRIEF-P t-scores were higher for cases than controls in shift and flexibility domains. Cases had lower PEDI-CAT mobility t-scores compared to controls. There was no difference in MABC between groups. In 11% of cases and 1% of controls, parents reported child mood problems. Conclusions: Children with in utero ZIKV exposure without CZS may demonstrate emerging differences in executive function, mood, and adaptive mobility that require continued evaluation. Impact: Preschool neurodevelopmental outcome in children with in utero Zika virus exposure is not yet known, since the Zika virus epidemic occurred in 2015–2017 and these children are only now entering school age.This study finds that Colombian children with in utero Zika virus exposure without congenital Zika syndrome are overall developing well but may have emerging differences in executive function, behavior and mood, and adaptive mobility compared to children without in utero Zika virus exposure.Children with in utero Zika virus exposure require continued multi-domain longitudinal neurodevelopmental evaluation through school age.

Original language	English (US)
Pages (from-to)	178-184
Number of pages	7
Journal	Pediatric research
Volume	94
Issue number	1
DOIs	https://doi.org/10.1038/s41390-022-02373-5
State	Published - Jul 2023

Funding

This work was supported by the Thrasher Research Fund. S.B.M. has additional funding from the Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award Number R01HD102445, and a contract with the U.S. Centers for Disease Control and Prevention for work on Zika virus separate from this study. C.P. receives support from National Center for Advancing Translational Sciences, Grant KL2TR001424.

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41390-022-02373-5

Cite this

Mulkey, S. B., Peyton, C., Ansusinha, E., Corn, E., Arroyave-Wessel, M., Zhang, A., Biddle, C., Gutierrez, C., Sorkar, A., Cure, A., Cure, D., du Plessis, A. J., DeBiasi, R. L., Msall, M. E., & Cure, C. (2023). Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome. Pediatric research, 94(1), 178-184. https://doi.org/10.1038/s41390-022-02373-5

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title = "Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome",

abstract = "Background: Children with in utero Zika virus (ZIKV) exposure without congenital Zika syndrome (CZS) are at risk for abnormal neurodevelopment. Preschool-age outcomes for children with antenatal ZIKV exposure have not yet been established. Methods: Children with in utero ZIKV exposure and non-exposed controls had neurodevelopmental evaluations at age 3–5 years in Sabanalarga, Colombia. Cases did not have CZS and were previously evaluated prenatally through age 18 months. Controls were born before ZIKV arrival to Colombia. Neurodevelopmental assessments included Pediatric Evaluation of Disability Inventory (PEDI-CAT), Behavior Rating Inventory of Executive Function (BRIEF-P), Bracken School Readiness Assessment (BSRA), and Movement Assessment Battery for Children (MABC). Family demographics and child medical history were recorded. Results: Fifty-five ZIKV-exposed children were evaluated at mean age 3.6 years and 70 controls were evaluated at 5.2 years. Family demographics were similar between groups. BRIEF-P t-scores were higher for cases than controls in shift and flexibility domains. Cases had lower PEDI-CAT mobility t-scores compared to controls. There was no difference in MABC between groups. In 11% of cases and 1% of controls, parents reported child mood problems. Conclusions: Children with in utero ZIKV exposure without CZS may demonstrate emerging differences in executive function, mood, and adaptive mobility that require continued evaluation. Impact: Preschool neurodevelopmental outcome in children with in utero Zika virus exposure is not yet known, since the Zika virus epidemic occurred in 2015–2017 and these children are only now entering school age.This study finds that Colombian children with in utero Zika virus exposure without congenital Zika syndrome are overall developing well but may have emerging differences in executive function, behavior and mood, and adaptive mobility compared to children without in utero Zika virus exposure.Children with in utero Zika virus exposure require continued multi-domain longitudinal neurodevelopmental evaluation through school age.",

author = "Mulkey, {Sarah B.} and Colleen Peyton and Emily Ansusinha and Elizabeth Corn and Margarita Arroyave-Wessel and Anqing Zhang and Cara Biddle and Corina Gutierrez and Andrea Sorkar and Andres Cure and Daniela Cure and {du Plessis}, {Adre J.} and DeBiasi, {Roberta L.} and Msall, {Michael E.} and Carlos Cure",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.",

year = "2023",

month = jul,

doi = "10.1038/s41390-022-02373-5",

language = "English (US)",

volume = "94",

pages = "178--184",

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Mulkey, SB, Peyton, C, Ansusinha, E, Corn, E, Arroyave-Wessel, M, Zhang, A, Biddle, C, Gutierrez, C, Sorkar, A, Cure, A, Cure, D, du Plessis, AJ, DeBiasi, RL, Msall, ME & Cure, C 2023, 'Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome', Pediatric research, vol. 94, no. 1, pp. 178-184. https://doi.org/10.1038/s41390-022-02373-5

TY - JOUR

T1 - Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome

AU - Mulkey, Sarah B.

AU - Peyton, Colleen

AU - Ansusinha, Emily

AU - Corn, Elizabeth

AU - Arroyave-Wessel, Margarita

AU - Zhang, Anqing

AU - Biddle, Cara

AU - Gutierrez, Corina

AU - Sorkar, Andrea

AU - Cure, Andres

AU - Cure, Daniela

AU - du Plessis, Adre J.

AU - DeBiasi, Roberta L.

AU - Msall, Michael E.

AU - Cure, Carlos

PY - 2023/7

Y1 - 2023/7

N2 - Background: Children with in utero Zika virus (ZIKV) exposure without congenital Zika syndrome (CZS) are at risk for abnormal neurodevelopment. Preschool-age outcomes for children with antenatal ZIKV exposure have not yet been established. Methods: Children with in utero ZIKV exposure and non-exposed controls had neurodevelopmental evaluations at age 3–5 years in Sabanalarga, Colombia. Cases did not have CZS and were previously evaluated prenatally through age 18 months. Controls were born before ZIKV arrival to Colombia. Neurodevelopmental assessments included Pediatric Evaluation of Disability Inventory (PEDI-CAT), Behavior Rating Inventory of Executive Function (BRIEF-P), Bracken School Readiness Assessment (BSRA), and Movement Assessment Battery for Children (MABC). Family demographics and child medical history were recorded. Results: Fifty-five ZIKV-exposed children were evaluated at mean age 3.6 years and 70 controls were evaluated at 5.2 years. Family demographics were similar between groups. BRIEF-P t-scores were higher for cases than controls in shift and flexibility domains. Cases had lower PEDI-CAT mobility t-scores compared to controls. There was no difference in MABC between groups. In 11% of cases and 1% of controls, parents reported child mood problems. Conclusions: Children with in utero ZIKV exposure without CZS may demonstrate emerging differences in executive function, mood, and adaptive mobility that require continued evaluation. Impact: Preschool neurodevelopmental outcome in children with in utero Zika virus exposure is not yet known, since the Zika virus epidemic occurred in 2015–2017 and these children are only now entering school age.This study finds that Colombian children with in utero Zika virus exposure without congenital Zika syndrome are overall developing well but may have emerging differences in executive function, behavior and mood, and adaptive mobility compared to children without in utero Zika virus exposure.Children with in utero Zika virus exposure require continued multi-domain longitudinal neurodevelopmental evaluation through school age.

AB - Background: Children with in utero Zika virus (ZIKV) exposure without congenital Zika syndrome (CZS) are at risk for abnormal neurodevelopment. Preschool-age outcomes for children with antenatal ZIKV exposure have not yet been established. Methods: Children with in utero ZIKV exposure and non-exposed controls had neurodevelopmental evaluations at age 3–5 years in Sabanalarga, Colombia. Cases did not have CZS and were previously evaluated prenatally through age 18 months. Controls were born before ZIKV arrival to Colombia. Neurodevelopmental assessments included Pediatric Evaluation of Disability Inventory (PEDI-CAT), Behavior Rating Inventory of Executive Function (BRIEF-P), Bracken School Readiness Assessment (BSRA), and Movement Assessment Battery for Children (MABC). Family demographics and child medical history were recorded. Results: Fifty-five ZIKV-exposed children were evaluated at mean age 3.6 years and 70 controls were evaluated at 5.2 years. Family demographics were similar between groups. BRIEF-P t-scores were higher for cases than controls in shift and flexibility domains. Cases had lower PEDI-CAT mobility t-scores compared to controls. There was no difference in MABC between groups. In 11% of cases and 1% of controls, parents reported child mood problems. Conclusions: Children with in utero ZIKV exposure without CZS may demonstrate emerging differences in executive function, mood, and adaptive mobility that require continued evaluation. Impact: Preschool neurodevelopmental outcome in children with in utero Zika virus exposure is not yet known, since the Zika virus epidemic occurred in 2015–2017 and these children are only now entering school age.This study finds that Colombian children with in utero Zika virus exposure without congenital Zika syndrome are overall developing well but may have emerging differences in executive function, behavior and mood, and adaptive mobility compared to children without in utero Zika virus exposure.Children with in utero Zika virus exposure require continued multi-domain longitudinal neurodevelopmental evaluation through school age.

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Preschool neurodevelopment in Zika virus-exposed children without congenital Zika syndrome

Abstract

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ASJC Scopus subject areas

UN SDGs

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