Presence of antibody to a primate RNA virus in human plasma

Byung S. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

AN antigen is present in leukocytes of patients with chronic myelogenous leukaemia (CML) which cross reacts with an antigen of the core protein of an RNA virus originally isolated from a Rhesus monkey, the Mason-Pfizer monkey virus (MPMY). This finding depended on development of a radioimmune assay using rabbit antibody raised against MPMV1. I report here that using a modified Farr technique2 plasma from some patients with various malignancies has antibody which reacts the MPMV core protein. The inference is that individuals in the human population may have been infected with a virus which is identical with or has antigens similar to those of the MPMV virus. The possible relevance of such infections to development of malignancies has yet to be determined.

Original languageEnglish (US)
Pages (from-to)614-616
Number of pages3
JournalNature
Volume257
Issue number5527
DOIs
StatePublished - Dec 1 1975

ASJC Scopus subject areas

  • General

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