AN antigen is present in leukocytes of patients with chronic myelogenous leukaemia (CML) which cross reacts with an antigen of the core protein of an RNA virus originally isolated from a Rhesus monkey, the Mason-Pfizer monkey virus (MPMY). This finding depended on development of a radioimmune assay using rabbit antibody raised against MPMV1. I report here that using a modified Farr technique2 plasma from some patients with various malignancies has antibody which reacts the MPMV core protein. The inference is that individuals in the human population may have been infected with a virus which is identical with or has antigens similar to those of the MPMV virus. The possible relevance of such infections to development of malignancies has yet to be determined.
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