Presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantation

Paolo R.O. Salvalaggio, Peter F Whitington, Estella M Alonso, Riccardo A Superina*

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We studied the impact of multiple bile duct anastomosis on the development of biliary complications after liver transplantation in children. A total of 101 patients received a primary liver transplant and were divided into 2 groups: those with a single bile duct (n = 77) and those with multiple bile ducts (n = 24). Mean follow-up was 39.8 ± 20.8 months. A total of 27 patients presented with biliary complications (26.7%), 18 patients (18.7%) presented with early complications (12 leaks and 6 strictures), and 9 patients (8.9%) had late strictures. Hepatic artery thrombosis (HAT) and multiple bile ducts were significant risk factors for the development of biliary complications, and the presence of multiple bile ducts was an independent risk factor. Patients with multiple bile ducts had a significantly greater incidence of total biliary complications compared to those with single ducts. Patients with multiple ducts had a higher incidence of leaks when compared to those in the single duct group, but the incidence of strictures, both early and late, was similar in both groups. One-year patient and graft survivals were not statistically different in the 2 groups. In conclusion, the presence of more than one bile duct in the graft is an independent risk factor for the development of biliary complications after pediatric liver transplantation.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalLiver Transplantation
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2005

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Bile Ducts
Liver Transplantation
Pediatrics
Transplants
Liver
Incidence
Pathologic Constriction
Hepatic Artery
Graft Survival
Thrombosis

ASJC Scopus subject areas

  • Surgery
  • Hepatology
  • Transplantation

Cite this

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title = "Presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantation",
abstract = "We studied the impact of multiple bile duct anastomosis on the development of biliary complications after liver transplantation in children. A total of 101 patients received a primary liver transplant and were divided into 2 groups: those with a single bile duct (n = 77) and those with multiple bile ducts (n = 24). Mean follow-up was 39.8 ± 20.8 months. A total of 27 patients presented with biliary complications (26.7{\%}), 18 patients (18.7{\%}) presented with early complications (12 leaks and 6 strictures), and 9 patients (8.9{\%}) had late strictures. Hepatic artery thrombosis (HAT) and multiple bile ducts were significant risk factors for the development of biliary complications, and the presence of multiple bile ducts was an independent risk factor. Patients with multiple bile ducts had a significantly greater incidence of total biliary complications compared to those with single ducts. Patients with multiple ducts had a higher incidence of leaks when compared to those in the single duct group, but the incidence of strictures, both early and late, was similar in both groups. One-year patient and graft survivals were not statistically different in the 2 groups. In conclusion, the presence of more than one bile duct in the graft is an independent risk factor for the development of biliary complications after pediatric liver transplantation.",
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