Presence of phosphate-mediated cross-linkages in hard tissue collagens

Arthur Veis*, Robert J. Schlueter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


IT has often been suggested that covalent interchain cross-linkages contribute to the stability of collagen fibrils1,2. Gustavson 1 speculated that ester bonds exist between free carboxyl groups and the hydroxyl groups of the hydroxy amino-acids. The work of Gallop et al. 3 and Hörmann et al.4 has substantiated this proposal, implicating carbohydrate or sugar cross-linkage as well. We have found in our work with dentine collagen evidence for still another type of cross-linkage which might apply to the collagens of the calcified tissues, bone and dentine.

Original languageEnglish (US)
Number of pages1
Issue number4873
StatePublished - Dec 1 1963

ASJC Scopus subject areas

  • General


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