Presentation of neuromyelitis optica spectrum disorder after more than twenty years of systemic sclerosis

Zulma M. Hernndez*, Bruce A. Cohen, Joy Derwenskus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Neuromyelitis optica is an autoimmune disorder characterized by optic neuritis, transverse myelitis, and aquaporin-4 autoantibodies. The term "neuromyelitis optica spectrum disorder" refers neuromyelitis optica features occurring in association with other systemic rheumatologic conditions. We present a case of a 51-year-old woman with long-standing systemic sclerosis who developed transverse myelitis in association with the presence aquaporin-4 autoantibodies. This is the first report case of neuromyelitis optica spectrum disorder associated with systemic sclerosis. Given that patients with neuromyelitis optica spectrum disorder with aquaporin-4 autoantibodies have a high risk for clinical relapse, this report underscores the need for recognition of this disorder in patients with systemic sclerosis and neurological dysfunction.

Original languageEnglish (US)
Pages (from-to)202-203
Number of pages2
JournalMultiple Sclerosis and Related Disorders
Issue number4
StatePublished - Oct 2012


  • Aquaporin-4 antibodies
  • Devics disease
  • Neuromyelitis optica
  • Neuromyelitis optica spectrum disorder
  • Systemic sclerosis
  • Transverse myelitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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