@article{0829d63aebae4c87a91e4c28a417698e,
title = "Preserved SARS-CoV-2 Vaccine Cell-Mediated Immunogenicity in Patients With Inflammatory Bowel Disease on Immune-Modulating Therapies",
abstract = "Immune-modulating medications for inflammatory bowel diseases (IBDs) have been associated with suboptimal vaccine responses. There are conflicting data with SARS-CoV-2 vaccination. We therefore assessed SARS-CoV-2 vaccine immunogenicity at 2 weeks after second mRNA vaccination in 29 patients with IBD compared with 12 normal healthy donors. We observed reduced humoral immunity in patients with IBD on infliximab. However, we observed no difference in humoral and cell-mediated immunity in patients with IBD on infliximab with a thiopurine or vedolizumab compared with normal healthy donors. This is the first study to demonstrate comparable cell-mediated immunity with SARS-CoV-2 vaccination in patients with IBD treated with different immune-modulating medications.",
author = "Boland, {Brigid S.} and Benjamin Goodwin and Zeli Zhang and Nathaniel Bloom and Yu Kato and Jennifer Neill and Helen Le and Tiffani Tysl and Collins, {Angelina E.} and Dulai, {Parambir S.} and Siddharth Singh and Nguyen, {Nghia H.} and Alba Grifoni and Alessandro Sette and Daniela Weiskopf and Chang, {John T.} and Dan, {Jennifer M.}",
note = "Funding Information: Potential competing interests: B.S.B. reports consulting fees from Celgene and Takeda and research grants from Prometheus Biosciences and Gilead. A.E.C. reports consulting fees and speaking fees from AbbVie, Bristol Myers Squibb, Janssen, and Takeda. A.S. is a consultant for Gritstone Bio, Flow Pharma, Arcturus Therapeutics, ImmunoScape, CellCarta, Avalia, Moderna, Fortress and Repertoire. ACKNOWLEDGMENTS Funding Information: Financial support: This work was supported by NIH K23 DK123406 (B.S.B.), NIH P30 DK120515 (B.S.B.), NIH T15LM011271 (N.H.N.), NIH 75N9301900065 (D.W., A.S.), NIH U19AI142742 (Shane Crotty), and NIH K08 AI135078 (J.M.D.). Publisher Copyright: {\textcopyright} 2022 Lippincott Williams and Wilkins. All rights reserved.",
year = "2022",
month = apr,
day = "28",
doi = "10.14309/ctg.0000000000000484",
language = "English (US)",
volume = "13",
pages = "E00484",
journal = "Clinical and Translational Gastroenterology",
issn = "2155-384X",
publisher = "Nature Publishing Group",
number = "4",
}