Pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography-a normative study of younger and older adults

N. Nativ-Zeltzer*, J. A. Logemann, S. G. Zecker, P. J. Kahrilas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Background: We aimed to define normative values for novel pressure topography metrics for high-resolution pharyngeal-esophageal manofluorography. The effects of age, gender, and bolus properties were examined. Methods: Concurrent high-resolution manometry (HRM) and videofluoroscopy data were collected from 22 younger (aged 21-40) and 22 older (aged 60-80) healthy subjects. Pressure topography was analyzed by correlating pressure domains with videofluoroscopic events. Nine pressure topography metrics of the pharyngeal and proximal esophageal swallow were extracted; four of these were also compared with previously obtained esophageal HRM studies to assess the effects of catheter diameter. Key Results: Older individuals exhibited more vigorous contractility in the pharynx than did younger subjects with all bolus types, but the greatest values for both groups were with effortful swallow and on that measure the age groups were similar. Upper esophageal sphincter (UES) intrabolus pressure during sphincter opening was also greater in the older subjects. Some gender differences were observed, particularly related to proximal esophageal contractile vigor. Bolus consistency had no consistent effect. Studies using the larger catheter diameter resulted in significantly greater contractile vigor in the UES and proximal esophagus. Conclusions & Inferences: Older adults exhibited more vigorous pharyngeal contractions than young adults, albeit within a similar range of capacity, perhaps reflecting a compensatory response to other age-related physiological changes. Greater UES intrabolus pressures observed during bolus transit in the older group likely reflect reduced UES compliance with age. Normative data on novel HRM metrics collected in this study can serve as a reference for future clinical studies.

Original languageEnglish (US)
Pages (from-to)721-731
Number of pages11
JournalNeurogastroenterology and Motility
Issue number5
StatePublished - May 1 2016


  • Dysphagia
  • High-resolution manometry
  • Mano-fluorography
  • Pharyngeal swallow
  • Upper esophageal sphincter

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


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