Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification

Peter Dallos*, Xudong Wu, Mary Ann Cheatham, Jiangang Gao, Jing Zheng, Charles T. Anderson, Shuping Jia, Xiang Wang, Wendy H.Y. Cheng, Soma Sengupta, David Z.Z. He, Jian Zuo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

233 Scopus citations

Abstract

It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophysiological phenotyping of a prestin knockout mouse intimated that somatic motility is the amplifier. However, outer hair cells of knockout mice have significantly altered mechanical properties, making this mouse model unsatisfactory. Here, we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function. These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalNeuron
Volume58
Issue number3
DOIs
StatePublished - May 8 2008

Keywords

  • MOLNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

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