Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification

Peter Dallos*, Xudong Wu, Mary Ann Cheatham, Jiangang Gao, Jing Zheng, Charles T. Anderson, Shuping Jia, Xiang Wang, Wendy H.Y. Cheng, Soma Sengupta, David Z.Z. He, Jian Zuo

*Corresponding author for this work

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophysiological phenotyping of a prestin knockout mouse intimated that somatic motility is the amplifier. However, outer hair cells of knockout mice have significantly altered mechanical properties, making this mouse model unsatisfactory. Here, we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function. These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalNeuron
Volume58
Issue number3
DOIs
StatePublished - May 8 2008

Fingerprint

Outer Auditory Hair Cells
Cochlea
Knockout Mice
Cell Movement
Mechanical Phenomena
Organ of Corti
Neurobiology
Mechanics
Ear
Proteins

Keywords

  • MOLNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dallos, P., Wu, X., Cheatham, M. A., Gao, J., Zheng, J., Anderson, C. T., ... Zuo, J. (2008). Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification. Neuron, 58(3), 333-339. https://doi.org/10.1016/j.neuron.2008.02.028
Dallos, Peter ; Wu, Xudong ; Cheatham, Mary Ann ; Gao, Jiangang ; Zheng, Jing ; Anderson, Charles T. ; Jia, Shuping ; Wang, Xiang ; Cheng, Wendy H.Y. ; Sengupta, Soma ; He, David Z.Z. ; Zuo, Jian. / Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification. In: Neuron. 2008 ; Vol. 58, No. 3. pp. 333-339.
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Dallos, P, Wu, X, Cheatham, MA, Gao, J, Zheng, J, Anderson, CT, Jia, S, Wang, X, Cheng, WHY, Sengupta, S, He, DZZ & Zuo, J 2008, 'Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification', Neuron, vol. 58, no. 3, pp. 333-339. https://doi.org/10.1016/j.neuron.2008.02.028

Prestin-Based Outer Hair Cell Motility Is Necessary for Mammalian Cochlear Amplification. / Dallos, Peter; Wu, Xudong; Cheatham, Mary Ann; Gao, Jiangang; Zheng, Jing; Anderson, Charles T.; Jia, Shuping; Wang, Xiang; Cheng, Wendy H.Y.; Sengupta, Soma; He, David Z.Z.; Zuo, Jian.

In: Neuron, Vol. 58, No. 3, 08.05.2008, p. 333-339.

Research output: Contribution to journalArticle

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AU - Anderson, Charles T.

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