Prestin expression in the cochlea of the reeler mouse

Jing Zheng, Claus Peter Richter, Mary Ann Cheatham

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Because reelin and prestin genes are located close together on mouse chromosome 5, reelin homozygous mutant mice were compared with littermate controls. Experiments were designed to determine if the deletion in the reeler mouse affects the coding and/or regulatory regions for the expression of prestin, the outer hair cell motor protein. Data indicate that homozygous reeler mice express prestin mRNA and protein, as do controls. Cochlear sensitivity, determined using compound action potential thresholds measured at the round window, is also similar. Hence, threshold shifts previously observed in auditory brainstem responses are not due to cochlear problems. Because prestin expression is not affected in reeler mice, prestin's coding region, as well as any regulatory elements, is predicted to lie in the 17 kb that separate prestin's exon 1 from the end of the deletion.

Original languageEnglish (US)
Pages (from-to)13-16
Number of pages4
JournalNeuroscience Letters
Volume347
Issue number1
DOIs
StatePublished - Aug 14 2003

Fingerprint

Neurologic Mutant Mice
Cochlea
Outer Auditory Hair Cells
Chromosomes, Human, Pair 5
Brain Stem Auditory Evoked Potentials
Nucleic Acid Regulatory Sequences
Action Potentials
Exons
Proteins
Messenger RNA
Genes

Keywords

  • Cochlea
  • Mouse
  • Outer hair cells
  • Prestin
  • Reelin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "Because reelin and prestin genes are located close together on mouse chromosome 5, reelin homozygous mutant mice were compared with littermate controls. Experiments were designed to determine if the deletion in the reeler mouse affects the coding and/or regulatory regions for the expression of prestin, the outer hair cell motor protein. Data indicate that homozygous reeler mice express prestin mRNA and protein, as do controls. Cochlear sensitivity, determined using compound action potential thresholds measured at the round window, is also similar. Hence, threshold shifts previously observed in auditory brainstem responses are not due to cochlear problems. Because prestin expression is not affected in reeler mice, prestin's coding region, as well as any regulatory elements, is predicted to lie in the 17 kb that separate prestin's exon 1 from the end of the deletion.",
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Prestin expression in the cochlea of the reeler mouse. / Zheng, Jing; Richter, Claus Peter; Cheatham, Mary Ann.

In: Neuroscience Letters, Vol. 347, No. 1, 14.08.2003, p. 13-16.

Research output: Contribution to journalArticle

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AU - Zheng, Jing

AU - Richter, Claus Peter

AU - Cheatham, Mary Ann

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