Prestin, the motor protein of outer hair cells

Jing Zheng*, Laird D. Madison, Dominik Oliver, Bernd Fakler, Peter Dallos

*Corresponding author for this work

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Prestin is a gene recently cloned from mammalian cochlear outer hair cells (OHC) using a single cell type, outer minus inner hair cell, specific suppressive subtractive hybridization procedure. The localization and gene expression profile of the prestin protein fits the pattern of OHC's development of electromotility. When prestin is abundantly expressed in normally nonmotile kidney cells, nonlinear capacitance and motility that are normally only seen in OHCs can be recorded. Furthermore, both nonlinear capacitance and motility can be reduced by salicylate, a well-known inhibitor of electromotility. These data suggest that prestin is the motor protein of OHCs. Amino acid sequence and gene structure analysis indicate that prestin is the fifth member of a newly discovered anion transport family (SLC26) that includes PDS, DRA and DTDST, which are chloride-iodide transporters, Cl-/HCO3- exchangers or sulfate transporters. Prestin shares overall structure similarity with this anion transporter family. Recently, intracellular anions (chloride or bicarbonate) were found to be essential for OHC electromotility and prestin's function.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalAudiology and Neuro-Otology
Volume7
Issue number1
DOIs
StatePublished - Apr 6 2002

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Keywords

  • Anion transporter
  • Electromotility
  • Motor protein
  • Outer hair cell
  • Prestin

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Neuroscience(all)
  • Physiology

Cite this

Zheng, J., Madison, L. D., Oliver, D., Fakler, B., & Dallos, P. (2002). Prestin, the motor protein of outer hair cells. Audiology and Neuro-Otology, 7(1), 9-12. https://doi.org/10.1159/000046855